osteoarthritis Gene Set

Dataset	MPO Gene-Phenotype Associations
Category	disease or phenotype associations
Type	phenotype
Description	A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans. (Experimental Factor Ontology, EFO_0002506)
External Link	http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003560
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Genes

16 gene mutations causing the osteoarthritis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol	Name
ATP7A	ATPase, Cu++ transporting, alpha polypeptide
BGN	biglycan
COL11A1	collagen, type XI, alpha 1
COL9A1	collagen, type IX, alpha 1
COMP	cartilage oligomeric matrix protein
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1
ERRFI1	ERBB receptor feedback inhibitor 1
FMOD	fibromodulin
HSPG2	heparan sulfate proteoglycan 2
HYAL1	hyaluronoglucosaminidase 1
LTBP3	latent transforming growth factor beta binding protein 3
MATN3	matrilin 3
MIR140	microRNA 140
MMP3	matrix metallopeptidase 3
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)
SMAD3	SMAD family member 3