osteoclast Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A large multinucleate cell found in growing bone that resorbs bony tissue, as in the formation of canals and cavities. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000968)
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Genes

134 genes co-occuring with the biological term osteoclast in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ACVR1 activin A receptor, type I
ADRM1 adhesion regulating molecule 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANGPTL4 angiopoietin-like 4
ANXA8 annexin A8
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
BCAR1 breast cancer anti-estrogen resistance 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
CALCA calcitonin-related polypeptide alpha
CALCR calcitonin receptor
CAMK4 calcium/calmodulin-dependent protein kinase IV
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL2 chemokine (C-C motif) ligand 2
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CLEC2D C-type lectin domain family 2, member D
CNR2 cannabinoid receptor 2 (macrophage)
CSF1 colony stimulating factor 1 (macrophage)
CSTB cystatin B (stefin B)
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DCSTAMP dendrocyte expressed seven transmembrane protein
DNM1 dynamin 1
DYNLL1 dynein, light chain, LC8-type 1
EPAS1 endothelial PAS domain protein 1
ESR1 estrogen receptor 1
FAM102A family with sequence similarity 102, member A
FAM213A family with sequence similarity 213, member A
FASLG Fas ligand (TNF superfamily, member 6)
FBN1 fibrillin 1
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GDF15 growth differentiation factor 15
GPR55 G protein-coupled receptor 55
HDAC3 histone deacetylase 3
HES1 hes family bHLH transcription factor 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IL11 interleukin 11
IL17A interleukin 17A
IL1B interleukin 1, beta
IL23A interleukin 23, alpha subunit p19
IL2RA interleukin 2 receptor, alpha
IL32 interleukin 32
IL4 interleukin 4
IL6 interleukin 6
IL7 interleukin 7
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITLN1 intelectin 1 (galactofuranose binding)
JUN jun proto-oncogene
KDR kinase insert domain receptor
LEP leptin
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LPXN leupaxin
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPKAP1 mitogen-activated protein kinase associated protein 1
MDK midkine (neurite growth-promoting factor 2)
MFGE8 milk fat globule-EGF factor 8 protein
MIR126 microRNA 126
MIR148A microRNA 148a
MIR29B1 microRNA 29b-1
MIR30A microRNA 30a
MITF microphthalmia-associated transcription factor
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP3 matrix metallopeptidase 3
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOG noggin
NOTCH1 notch 1
NOX4 NADPH oxidase 4
ORAI1 ORAI calcium release-activated calcium modulator 1
OSCAR osteoclast associated, immunoglobulin-like receptor
OSTF1 osteoclast stimulating factor 1
OXTR oxytocin receptor
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PTGDR2 prostaglandin D2 receptor 2
PTH parathyroid hormone
PTHLH parathyroid hormone-like hormone
PTK2 protein tyrosine kinase 2
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RGS10 regulator of G-protein signaling 10
RHOU ras homolog family member U
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
SH3BP2 SH3-domain binding protein 2
SH3PXD2A SH3 and PX domains 2A
SHH sonic hedgehog
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
SMAD3 SMAD family member 3
SNX10 sorting nexin 10
SOST sclerostin
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPI1 Spi-1 proto-oncogene
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TGFB1 transforming growth factor, beta 1
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIP6 thyroid hormone receptor interactor 6
TXNIP thioredoxin interacting protein
TYRO3 TYRO3 protein tyrosine kinase
VCAM1 vascular cell adhesion molecule 1
XBP1 X-box binding protein 1
ZBTB7A zinc finger and BTB domain containing 7A
ZFAND5 zinc finger, AN1-type domain 5
ZNF675 zinc finger protein 675