osteoclast Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description A large multinucleate cell found in growing bone that resorbs bony tissue, as in the formation of canals and cavities. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000968)
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Genes

699 proteins co-occuring with the tissue osteoclast in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 3.70929
ACPP acid phosphatase, prostate 3.62168
CTSK cathepsin K 3.53605
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 3.4518
PTH parathyroid hormone 3.03569
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 3.01087
BGLAP bone gamma-carboxyglutamate (gla) protein 2.75058
CALCR calcitonin receptor 2.6248
CALCA calcitonin-related polypeptide alpha 2.48564
ALPL alkaline phosphatase, liver/bone/kidney 2.47817
ALPPL2 alkaline phosphatase, placental-like 2 2.47382
ALPP alkaline phosphatase, placental 2.47258
PTHLH parathyroid hormone-like hormone 2.32183
DCSTAMP dendrocyte expressed seven transmembrane protein 2.27286
SPP1 secreted phosphoprotein 1 2.15702
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 2.12832
SOST sclerostin 2.09151
RUNX2 runt-related transcription factor 2 2.08509
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 2.08456
CSF1R colony stimulating factor 1 receptor 2.06905
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.99374
CLCN7 chloride channel, voltage-sensitive 7 1.98525
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 1.96198
OSCAR osteoclast associated, immunoglobulin-like receptor 1.95882
SEBOX SEBOX homeobox 1.94306
ACP5 acid phosphatase 5, tartrate resistant 1.90187
IL6 interleukin 6 1.85431
TNF tumor necrosis factor 1.83785
SP7 Sp7 transcription factor 1.8235
MMP9 matrix metallopeptidase 9 1.80972
BMP2 bone morphogenetic protein 2 1.80666
FOS FBJ murine osteosarcoma viral oncogene homolog 1.74825
CA2 carbonic anhydrase II 1.71589
CSF1 colony stimulating factor 1 (macrophage) 1.71291
MITF microphthalmia-associated transcription factor 1.70893
CD68 CD68 molecule 1.69002
IBSP integrin-binding sialoprotein 1.68254
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.67206
OSTM1 osteopetrosis associated transmembrane protein 1 1.62956
DNAH8 dynein, axonemal, heavy chain 8 1.62457
TYROBP TYRO protein tyrosine kinase binding protein 1.61509
IL1A interleukin 1, alpha 1.58782
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.55309
CTSS cathepsin S 1.52331
TGFB1 transforming growth factor, beta 1 1.5138
IL1B interleukin 1, beta 1.5119
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.50291
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.50056
OCSTAMP osteoclast stimulatory transmembrane protein 1.49302
SH3BP2 SH3-domain binding protein 2 1.48458
FDPS farnesyl diphosphate synthase 1.47989
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 1.44497
IGF1 insulin-like growth factor 1 (somatomedin C) 1.44172
MMP13 matrix metallopeptidase 13 1.44033
SQSTM1 sequestosome 1 1.42414
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 1.4011
IL11 interleukin 11 1.38688
ESR1 estrogen receptor 1 1.34406
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.30298
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 1.28592
VAV3 vav 3 guanine nucleotide exchange factor 1.27247
JUN jun proto-oncogene 1.25324
CCL3 chemokine (C-C motif) ligand 3 1.25101
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 1.24744
LRP5 low density lipoprotein receptor-related protein 5 1.23093
ITGAV integrin, alpha V 1.22826
COL1A1 collagen, type I, alpha 1 1.20867
CTSL cathepsin L 1.19889
OAF OAF homolog (Drosophila) 1.19267
MIR4315-1 microRNA 4315-1 1.18423
MIR4315-2 microRNA 4315-2 1.18423
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 1.18379
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.17713
SIGLEC15 sialic acid binding Ig-like lectin 15 1.16914
MEPE matrix extracellular phosphoglycoprotein 1.1656
PTH1R parathyroid hormone 1 receptor 1.15584
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.15362
COL1A2 collagen, type I, alpha 2 1.15052
CASR calcium-sensing receptor 1.13058
CSK c-src tyrosine kinase 1.12837
BMP7 bone morphogenetic protein 7 1.11022
CLEC2D C-type lectin domain family 2, member D 1.09872
CTSB cathepsin B 1.09827
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 1.09827
FGF23 fibroblast growth factor 23 1.07574
SNX10 sorting nexin 10 1.05853
EPHB4 EPH receptor B4 1.05325
EFNB2 ephrin-B2 1.04664
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.03961
MMP2 matrix metallopeptidase 2 1.03478
TFE3 transcription factor binding to IGHM enhancer 3 1.0282
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.02557
GAB2 GRB2-associated binding protein 2 1.02162
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.02162
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.01331
KNTC1 kinetochore associated 1 1.00196
TREM2 triggering receptor expressed on myeloid cells 2 0.994119
SYK spleen tyrosine kinase 0.993684
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 0.991509
MMP1 matrix metallopeptidase 1 0.988032
PTPRO protein tyrosine phosphatase, receptor type, O 0.980651
CXCL12 chemokine (C-X-C motif) ligand 12 0.968523
ADAM8 ADAM metallopeptidase domain 8 0.962471
RAP1A RAP1A, member of RAS oncogene family 0.941785
MAPK8 mitogen-activated protein kinase 8 0.939206
BMP6 bone morphogenetic protein 6 0.932766
IL17A interleukin 17A 0.932766
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.922483
LEP leptin 0.921199
VEGFA vascular endothelial growth factor A 0.921199
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.917779
CCR1 chemokine (C-C motif) receptor 1 0.91052
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.899871
CCL2 chemokine (C-C motif) ligand 2 0.895195
EDA ectodysplasin A 0.890525
CD44 CD44 molecule (Indian blood group) 0.875284
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.874439
IL34 interleukin 34 0.863891
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.857995
MMP3 matrix metallopeptidase 3 0.856312
IHH indian hedgehog 0.854629
VCL vinculin 0.844545
GSN gelsolin 0.83951
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 0.833642
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.832804
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.829872
FN1 fibronectin 1 0.828616
FOSL1 FOS-like antigen 1 0.827778
TFEC transcription factor EC 0.824431
LTA lymphotoxin alpha 0.819412
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.819412
GJA1 gap junction protein, alpha 1, 43kDa 0.814815
MGP matrix Gla protein 0.811473
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.809386
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.808968
TIMP1 TIMP metallopeptidase inhibitor 1 0.808551
PPARG peroxisome proliferator-activated receptor gamma 0.80563
IL4 interleukin 4 0.801459
ATP11A ATPase, class VI, type 11A 0.798958
IL6R interleukin 6 receptor 0.796874
CD34 CD34 molecule 0.796458
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.793126
GC group-specific component (vitamin D binding protein) 0.788964
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.786052
TLR4 toll-like receptor 4 0.78522
FGF2 fibroblast growth factor 2 (basic) 0.783972
GPR68 G protein-coupled receptor 68 0.777325
IL1RN interleukin 1 receptor antagonist 0.775664
TFEB transcription factor EB 0.775664
WNT3A wingless-type MMTV integration site family, member 3A 0.774004
CTTN cortactin 0.77027
IAPP islet amyloid polypeptide 0.760742
OSM oncostatin M 0.75247
PHEX phosphate regulating endopeptidase homolog, X-linked 0.746277
TSPO translocator protein (18kDa) 0.742976
TGFB2 transforming growth factor, beta 2 0.742564
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.738442
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.737206
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.732265
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.73062
DLX5 distal-less homeobox 5 0.730208
TMEM64 transmembrane protein 64 0.724041
PXN paxillin 0.722398
GUSB glucuronidase, beta 0.717061
ESR2 estrogen receptor 2 (ER beta) 0.71583
RHOU ras homolog family member U 0.712139
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.711729
DOCK5 dedicator of cytokinesis 5 0.71009
BMP4 bone morphogenetic protein 4 0.70927
HEBP1 heme binding protein 1 0.705173
CASC4 cancer susceptibility candidate 4 0.702308
ADAM12 ADAM metallopeptidase domain 12 0.702308
CD4 CD4 molecule 0.701899
MAPK14 mitogen-activated protein kinase 14 0.696989
FAM105A family with sequence similarity 105, member A 0.693311
PTPRD protein tyrosine phosphatase, receptor type, D 0.691676
CHN2 chimerin 2 0.682287
IL7 interleukin 7 0.67495
IRF6 interferon regulatory factor 6 0.671285
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.665182
TRPV5 transient receptor potential cation channel, subfamily V, member 5 0.663962
JDP2 Jun dimerization protein 2 0.661116
SIRPA signal-regulatory protein alpha 0.644074
LYZ lysozyme 0.642858
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.642454
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.640833
FLT1 fms-related tyrosine kinase 1 0.637999
NF1 neurofibromin 1 0.635572
MGAM maltase-glucoamylase 0.635572
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.631123
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.630718
IL3 interleukin 3 0.627889
CD47 CD47 molecule 0.622235
B2M beta-2-microglobulin 0.621428
ATF4 activating transcription factor 4 0.621024
INS insulin 0.619814
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.617796
NOG noggin 0.613764
STAT1 signal transducer and activator of transcription 1, 91kDa 0.606514
CD163 CD163 molecule 0.604904
TBC1D25 TBC1 domain family, member 25 0.596862
AHSG alpha-2-HS-glycoprotein 0.594451
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.594451
ZNF384 zinc finger protein 384 0.590036
SMAD2 SMAD family member 2 0.587629
TWSG1 twisted gastrulation BMP signaling modulator 1 0.587629
BTK Bruton agammaglobulinemia tyrosine kinase 0.580417
TLR2 toll-like receptor 2 0.579617
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 0.578816
ANXA2R annexin A2 receptor 0.578816
ANXA2 annexin A2 0.576415
PTPRC protein tyrosine phosphatase, receptor type, C 0.572818
ALB albumin 0.571619
FASLG Fas ligand (TNF superfamily, member 6) 0.57082
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.565631
AR androgen receptor 0.564434
NEK8 NIMA-related kinase 8 0.564434
SFRP1 secreted frizzled-related protein 1 0.561644
LRP6 low density lipoprotein receptor-related protein 6 0.558457
CREB1 cAMP responsive element binding protein 1 0.55607
GPNMB glycoprotein (transmembrane) nmb 0.548914
IL18 interleukin 18 0.544152
ANKH ANKH inorganic pyrophosphate transport regulator 0.539793
FGFR3 fibroblast growth factor receptor 3 0.53346
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.53346
NOTCH1 notch 1 0.531879
EGFL6 EGF-like-domain, multiple 6 0.526744
MAPK3 mitogen-activated protein kinase 3 0.518465
PCNA proliferating cell nuclear antigen 0.516104
CTGF connective tissue growth factor 0.514136
LPXN leupaxin 0.512957
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.510992
TP53 tumor protein p53 0.509813
ENO2 enolase 2 (gamma, neuronal) 0.508635
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.508242
RNF185 ring finger protein 185 0.507849
ACAN aggrecan 0.507064
MMP25 matrix metallopeptidase 25 0.506279
CST3 cystatin C 0.50471
GBA glucosidase, beta, acid 0.503141
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.497657
PIAS3 protein inhibitor of activated STAT, 3 0.493745
KREMEN2 kringle containing transmembrane protein 2 0.4914
ADCY2 adenylate cyclase 2 (brain) 0.490814
TGFB3 transforming growth factor, beta 3 0.489838
NOX1 NADPH oxidase 1 0.486326
PTS 6-pyruvoyltetrahydropterin synthase 0.483596
RGS12 regulator of G-protein signaling 12 0.48087
RXFP2 relaxin/insulin-like family peptide receptor 2 0.479312
CAMK2B calcium/calmodulin-dependent protein kinase II beta 0.478923
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.477367
PGM1 phosphoglucomutase 1 0.476201
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.474646
HMGB1 high mobility group box 1 0.47348
CTSC cathepsin C 0.466498
PTK2B protein tyrosine kinase 2 beta 0.462626
FSHR follicle stimulating hormone receptor 0.460692
GDNF glial cell derived neurotrophic factor 0.459725
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.458759
NMB neuromedin B 0.456055
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.454126
OSMR oncostatin M receptor 0.452969
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.451042
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.449886
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 0.448731
IGFBP5 insulin-like growth factor binding protein 5 0.448346
WNT10B wingless-type MMTV integration site family, member 10B 0.448346
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.447961
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa 0.447961
ICAM1 intercellular adhesion molecule 1 0.447961
CLDN18 claudin 18 0.446807
RHOF ras homolog family member F (in filopodia) 0.444884
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.443923
IL1R1 interleukin 1 receptor, type I 0.44181
CCL13 chemokine (C-C motif) ligand 13 0.441426
NET1 neuroepithelial cell transforming 1 0.439123
SFRP2 secreted frizzled-related protein 2 0.437972
FGF1 fibroblast growth factor 1 (acidic) 0.437205
CDC42 cell division cycle 42 0.436822
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.43414
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.433757
BMP5 bone morphogenetic protein 5 0.426872
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.426872
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.425344
HBA2 hemoglobin, alpha 2 0.425344
NGF nerve growth factor (beta polypeptide) 0.42439
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.421148
HBA1 hemoglobin, alpha 1 0.418099
OGN osteoglycin 0.415814
CRP C-reactive protein, pentraxin-related 0.415053
CXCL8 chemokine (C-X-C motif) ligand 8 0.413532
FRZB frizzled-related protein 0.411251
TIMP2 TIMP metallopeptidase inhibitor 2 0.408972
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.405555
LIFR leukemia inhibitory factor receptor alpha 0.404797
MMP7 matrix metallopeptidase 7 0.404418
DCAF13 DDB1 and CUL4 associated factor 13 0.40328
JUND jun D proto-oncogene 0.401386
MMP8 matrix metallopeptidase 8 0.401386
MAGEB18 melanoma antigen family B18 0.399303
ANXA7 annexin A7 0.398735
LTBP3 latent transforming growth factor beta binding protein 3 0.397979
VAV1 vav 1 guanine nucleotide exchange factor 0.397979
LIMD1 LIM domains containing 1 0.3976
ZNF446 zinc finger protein 446 0.396844
BLNK B-cell linker 0.396087
PDE4A phosphodiesterase 4A, cAMP-specific 0.394576
TAC1 tachykinin, precursor 1 0.393442
FOXO4 forkhead box O4 0.391176
PAX5 paired box 5 0.391176
MSX2 msh homeobox 2 0.390421
GPR55 G protein-coupled receptor 55 0.387781
TYRO3 TYRO3 protein tyrosine kinase 0.386273
JAK2 Janus kinase 2 0.386273
LTBP2 latent transforming growth factor beta binding protein 2 0.38552
CPXM1 carboxypeptidase X (M14 family), member 1 0.385143
SOX9 SRY (sex determining region Y)-box 9 0.384766
VCP valosin containing protein 0.384013
S1PR2 sphingosine-1-phosphate receptor 2 0.382508
TANK TRAF family member-associated NFKB activator 0.382131
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.380627
FGD6 FYVE, RhoGEF and PH domain containing 6 0.379499
CCR2 chemokine (C-C motif) receptor 2 0.378748
DNTT DNA nucleotidylexotransferase 0.378372
ADAM10 ADAM metallopeptidase domain 10 0.378372
BCAR1 breast cancer anti-estrogen resistance 1 0.375743
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.374618
NPS neuropeptide S 0.373868
RGN regucalcin 0.373118
HSPA4 heat shock 70kDa protein 4 0.372556
MYD88 myeloid differentiation primary response 88 0.371619
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.370496
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.370121
CD9 CD9 molecule 0.369747
NOX4 NADPH oxidase 4 0.369373
CNR1 cannabinoid receptor 1 (brain) 0.368998
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.368624
NMBR neuromedin B receptor 0.367689
WAS Wiskott-Aldrich syndrome 0.364886
GFAP glial fibrillary acidic protein 0.364326
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.363766
FAAH fatty acid amide hydrolase 0.36302
BCL2L1 BCL2-like 1 0.362646
GBP4 guanylate binding protein 4 0.362273
SLC39A1 solute carrier family 39 (zinc transporter), member 1 0.359292
ARHGAP27 Rho GTPase activating protein 27 0.356128
CTSD cathepsin D 0.35557
ADAM17 ADAM metallopeptidase domain 17 0.35557
ACP2 acid phosphatase 2, lysosomal 0.351856
BMP3 bone morphogenetic protein 3 0.351114
MAP3K7CL MAP3K7 C-terminal like 0.34926
S100A9 S100 calcium binding protein A9 0.348889
ADRB1 adrenoceptor beta 1 0.346298
MST1 macrophage stimulating 1 0.345188
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.344818
CYLD cylindromatosis (turban tumor syndrome) 0.344449
MAG myelin associated glycoprotein 0.342971
FOXP3 forkhead box P3 0.342233
PLG plasminogen 0.340757
CD38 CD38 molecule 0.340388
HRAS Harvey rat sarcoma viral oncogene homolog 0.340019
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.338545
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.337072
CCND1 cyclin D1 0.336704
FGFR1 fibroblast growth factor receptor 1 0.3356
CTRC chymotrypsin C (caldecrin) 0.335233
EFNB1 ephrin-B1 0.335233
CXCL2 chemokine (C-X-C motif) ligand 2 0.335233
EGFR epidermal growth factor receptor 0.334865
PLAU plasminogen activator, urokinase 0.333763
CLEC5A C-type lectin domain family 5, member A 0.333396
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.332294
SYF2 SYF2 pre-mRNA-splicing factor 0.329544
TRAF3 TNF receptor-associated factor 3 0.328262
VCAM1 vascular cell adhesion molecule 1 0.327896
EFNA2 ephrin-A2 0.32753
CTF1 cardiotrophin 1 0.327164
CST5 cystatin D 0.326798
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 0.326432
KL klotho 0.325335
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 0.323509
HCK HCK proto-oncogene, Src family tyrosine kinase 0.323144
WDFY3 WD repeat and FYVE domain containing 3 0.322779
ADRM1 adhesion regulating molecule 1 0.322779
SLC4A2 solute carrier family 4 (anion exchanger), member 2 0.320591
TSHR thyroid stimulating hormone receptor 0.31877
IL33 interleukin 33 0.317679
S100B S100 calcium binding protein B 0.316224
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.315861
TSPAN5 tetraspanin 5 0.315135
EMP1 epithelial membrane protein 1 0.312957
CRTAP cartilage associated protein 0.312957
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.311145
BGN biglycan 0.311145
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.309335
TPM4 tropomyosin 4 0.308612
SDC1 syndecan 1 0.307528
SPHK1 sphingosine kinase 1 0.307167
BAX BCL2-associated X protein 0.307167
SMAD3 SMAD family member 3 0.307167
GLUL glutamate-ammonia ligase 0.305722
RAB9A RAB9A, member RAS oncogene family 0.305722
NCF1C neutrophil cytosolic factor 1C pseudogene 0.303559
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.303559
LRRC17 leucine rich repeat containing 17 0.301758
TOB2 transducer of ERBB2, 2 0.301398
SPI1 Spi-1 proto-oncogene 0.301039
TRIP6 thyroid hormone receptor interactor 6 0.300679
PTK2 protein tyrosine kinase 2 0.29996
FLNA filamin A, alpha 0.299242
AMBN ameloblastin (enamel matrix protein) 0.297806
COMP cartilage oligomeric matrix protein 0.297806
HMOX1 heme oxygenase 1 0.29673
CXCL5 chemokine (C-X-C motif) ligand 5 0.294223
CX3CR1 chemokine (C-X3-C motif) receptor 1 0.293508
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.293151
LTF lactotransferrin 0.291365
ATG7 autophagy related 7 0.290652
IPP intracisternal A particle-promoted polypeptide 0.289582
SYT7 synaptotagmin VII 0.28887
SMAD5 SMAD family member 5 0.288514
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 0.287447
OPRM1 opioid receptor, mu 1 0.287092
USP6 ubiquitin specific peptidase 6 0.286736
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.284962
TGFBR1 transforming growth factor, beta receptor 1 0.284962
EGR2 early growth response 2 0.284253
IGFBP3 insulin-like growth factor binding protein 3 0.284253
NOTCH2NL notch 2 N-terminal like 0.280717
POSTN periostin, osteoblast specific factor 0.280364
BMPR1A bone morphogenetic protein receptor, type IA 0.279659
NOTCH2 notch 2 0.2779
MET MET proto-oncogene, receptor tyrosine kinase 0.277549
NCF1 neutrophil cytosolic factor 1 0.277197
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.274744
SFRP4 secreted frizzled-related protein 4 0.274045
ANKRD28 ankyrin repeat domain 28 0.273346
INSL3 insulin-like 3 (Leydig cell) 0.272997
IFNB1 interferon, beta 1, fibroblast 0.2723
FLT3 fms-related tyrosine kinase 3 0.269521
GRP gastrin-releasing peptide 0.269174
LYN LYN proto-oncogene, Src family tyrosine kinase 0.268828
TLN1 talin 1 0.267791
SOCS3 suppressor of cytokine signaling 3 0.266069
HDAC6 histone deacetylase 6 0.265381
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 0.264524
IFNG interferon, gamma 0.264353
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 0.264182
CNOT3 CCR4-NOT transcription complex, subunit 3 0.263327
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 0.261624
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 0.261284
FKBP7 FK506 binding protein 7 0.260775
FKBP9 FK506 binding protein 9, 63 kDa 0.260606
C1QB complement component 1, q subcomponent, B chain 0.260606
ZNF239 zinc finger protein 239 0.260267
ZNF233 zinc finger protein 233 0.260267
HYLS1 hydrolethalus syndrome 1 0.260267
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 0.259254
HPD 4-hydroxyphenylpyruvate dioxygenase 0.25774
CD300LF CD300 molecule-like family member f 0.257572
DCN decorin 0.257572
ERMN ermin, ERM-like protein 0.257404
FKBP6 FK506 binding protein 6, 36kDa 0.256234
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.255567
CYR61 cysteine-rich, angiogenic inducer, 61 0.253248
TLR9 toll-like receptor 9 0.252261
TWF1 twinfilin actin binding protein 1 0.251606
IL10 interleukin 10 0.251279
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 0.250953
FKBP3 FK506 binding protein 3, 25kDa 0.250953
DLX6 distal-less homeobox 6 0.250953
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.250627
TRAF5 TNF receptor-associated factor 5 0.250627
CARD17 caspase recruitment domain family, member 17 0.250301
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.250139
SBNO2 strawberry notch homolog 2 (Drosophila) 0.245175
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 0.244388
PDGFB platelet-derived growth factor beta polypeptide 0.243918
ITGB5 integrin, beta 5 0.242054
SMAD7 SMAD family member 7 0.242054
TWIST1 twist family bHLH transcription factor 1 0.241746
ADM adrenomedullin 0.241746
LIX1 Lix1 homolog (chicken) 0.240979
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.240826
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.240826
IL13 interleukin 13 0.239913
MRC1 mannose receptor, C type 1 0.239007
CCL22 chemokine (C-C motif) ligand 22 0.238108
LRRK1 leucine-rich repeat kinase 1 0.238108
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.23781
CD40LG CD40 ligand 0.23781
SDHAF2 succinate dehydrogenase complex assembly factor 2 0.23781
NOS3 nitric oxide synthase 3 (endothelial cell) 0.235457
IL32 interleukin 32 0.235167
RNF146 ring finger protein 146 0.233731
ORAI1 ORAI calcium release-activated calcium modulator 1 0.233162
KLK3 kallikrein-related peptidase 3 0.232599
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.232599
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.23176
TCF4 transcription factor 4 0.231206
WNT5B wingless-type MMTV integration site family, member 5B 0.230931
NOS1 nitric oxide synthase 1 (neuronal) 0.230382
S100G S100 calcium binding protein G 0.229839
CD200 CD200 molecule 0.229299
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.228898
THNSL2 threonine synthase-like 2 (S. cerevisiae) 0.228497
S1PR1 sphingosine-1-phosphate receptor 1 0.22797
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 0.22797
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.227707
CNR2 cannabinoid receptor 2 (macrophage) 0.227445
CCKBR cholecystokinin B receptor 0.227445
PRELP proline/arginine-rich end leucine-rich repeat protein 0.227445
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.227186
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.226667
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 0.226667
CTSO cathepsin O 0.225647
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.224645
EMC3 ER membrane protein complex subunit 3 0.224398
PENK proenkephalin 0.223784
CCL5 chemokine (C-C motif) ligand 5 0.223662
FKBP10 FK506 binding protein 10, 65 kDa 0.223057
BCL2A1 BCL2-related protein A1 0.22246
RPS19 ribosomal protein S19 0.222224
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 0.221989
PARK2 parkin RBR E3 ubiquitin protein ligase 0.221755
GIPR gastric inhibitory polypeptide receptor 0.221755
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.219928
GAS6 growth arrest-specific 6 0.219707
P3H1 prolyl 3-hydroxylase 1 0.219264
CYSLTR2 cysteinyl leukotriene receptor 2 0.219155
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.218398
OXCT2 3-oxoacid CoA transferase 2 0.217762
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.217762
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.217139
CHIT1 chitinase 1 (chitotriosidase) 0.21673
EGR1 early growth response 1 0.216629
AXIN1 axin 1 0.216528
PTPRE protein tyrosine phosphatase, receptor type, E 0.216325
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.21573
IRF8 interferon regulatory factor 8 0.21573
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 0.214954
LTBP1 latent transforming growth factor beta binding protein 1 0.214765
CD80 CD80 molecule 0.214202
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 0.213471
CALCRL calcitonin receptor-like 0.213291
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.212761
PROM1 prominin 1 0.212499
TUBA1A tubulin, alpha 1a 0.211819
CRYAB crystallin, alpha B 0.211571
PANX2 pannexin 2 0.211488
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 0.210137
CAT catalase 0.210061
IGFBP4 insulin-like growth factor binding protein 4 0.209683
FKBP2 FK506 binding protein 2, 13kDa 0.208464
ANXA5 annexin A5 0.208395
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 0.208258
ASIC1 acid sensing (proton gated) ion channel 1 0.207209
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 0.206299
NES nestin 0.206009
BDNF brain-derived neurotrophic factor 0.205295
MAP1B microtubule-associated protein 1B 0.205189
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.205189
GCH1 GTP cyclohydrolase 1 0.204432
ANXA4 annexin A4 0.204146
EDN3 endothelin 3 0.203692
SEPW1 selenoprotein W, 1 0.203647
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.203388
UBA3 ubiquitin-like modifier activating enzyme 3 0.202778
OXCT1 3-oxoacid CoA transferase 1 0.202293
NGFR nerve growth factor receptor 0.202012
KNG1 kininogen 1 0.201338
HSF1 heat shock transcription factor 1 0.201278
EEF2 eukaryotic translation elongation factor 2 0.201278
ANKRD23 ankyrin repeat domain 23 0.201047
GAS1 growth arrest-specific 1 0.200827
SSTR2 somatostatin receptor 2 0.20054
CAV1 caveolin 1, caveolae protein, 22kDa 0.200298
PLP1 proteolipid protein 1 0.200205
NOV nephroblastoma overexpressed 0.200026
CLTA clathrin, light chain A 0.199814
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.199426
SSTR5 somatostatin receptor 5 0.199197
TF transferrin 0.198969
CNTF ciliary neurotrophic factor 0.1988
NT5E 5'-nucleotidase, ecto (CD73) 0.198757
ADRB2 adrenoceptor beta 2, surface 0.198713
KRT31 keratin 31, type I 0.198491
PYGO2 pygopus family PHD finger 2 0.19815
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 0.198091
NOS2 nitric oxide synthase 2, inducible 0.197952
SSTR1 somatostatin receptor 1 0.197952
PLA2G1B phospholipase A2, group IB (pancreas) 0.197852
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.197543
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.197522
GUCY2C guanylate cyclase 2C 0.197502
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 0.197471
NPR1 natriuretic peptide receptor 1 0.19745
RGS8 regulator of G-protein signaling 8 0.197319
ATP7A ATPase, Cu++ transporting, alpha polypeptide 0.197209
MAOA monoamine oxidase A 0.197071
GPX1 glutathione peroxidase 1 0.197061
DNM2 dynamin 2 0.197061
SOD2 superoxide dismutase 2, mitochondrial 0.197051
ACAT1 acetyl-CoA acetyltransferase 1 0.197032
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 0.196934
THRA thyroid hormone receptor, alpha 0.196865
NFE2L2 nuclear factor, erythroid 2-like 2 0.196796
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.196786
BAG4 BCL2-associated athanogene 4 0.196767
MGMT O-6-methylguanine-DNA methyltransferase 0.196688
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.196649
DDIT3 DNA-damage-inducible transcript 3 0.196649
MX2 MX dynamin-like GTPase 2 0.19656
GMFB glia maturation factor, beta 0.1965
APP amyloid beta (A4) precursor protein 0.19644
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 0.19638
IRF1 interferon regulatory factor 1 0.196289
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.196218
GPX5 glutathione peroxidase 5 0.196167
SORT1 sortilin 1 0.196116
GPX4 glutathione peroxidase 4 0.196064
THOP1 thimet oligopeptidase 1 0.195886
CRTAM cytotoxic and regulatory T cell molecule 0.195769
ENDOG endonuclease G 0.195748
DENR density-regulated protein 0.195726
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 0.195694
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.19565
PPIF peptidylprolyl isomerase F 0.195574
UGT8 UDP glycosyltransferase 8 0.195541
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 0.195485
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 0.195385
DES desmin 0.195271
ADCY8 adenylate cyclase 8 (brain) 0.195156
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 0.19511
DAAM1 dishevelled associated activator of morphogenesis 1 0.194945
TTL tubulin tyrosine ligase 0.194861
CLIC4 chloride intracellular channel 4 0.194728
EDN1 endothelin 1 0.194617
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.194604
FKBP5 FK506 binding protein 5 0.194592
LRP4 low density lipoprotein receptor-related protein 4 0.194529
SLC38A5 solute carrier family 38, member 5 0.194428
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 0.194428
CCND3 cyclin D3 0.194326
RGS19 regulator of G-protein signaling 19 0.194274
ACTG1 actin gamma 1 0.19417
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 0.193971
NCAM1 neural cell adhesion molecule 1 0.193957
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.193739
EDNRA endothelin receptor type A 0.193257
PDZD2 PDZ domain containing 2 0.193242
MBTPS2 membrane-bound transcription factor peptidase, site 2 0.193139
PANX1 pannexin 1 0.193139
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.193124
AQP4 aquaporin 4 0.19305
IFT122 intraflagellar transport 122 0.19299
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.19293
LDHA lactate dehydrogenase A 0.192793
CAV2 caveolin 2 0.192638
BEND3 BEN domain containing 3 0.192607
MARS methionyl-tRNA synthetase 0.192607
BBS2 Bardet-Biedl syndrome 2 0.192607
ZNF79 zinc finger protein 79 0.192591
HMBS hydroxymethylbilane synthase 0.192575
IGF1R insulin-like growth factor 1 receptor 0.19256
HSPA8 heat shock 70kDa protein 8 0.192481
NUCLEOLIN nucleolin multifunctional protein 0.192433
RD3 retinal degeneration 3 0.192337
MIR27B microRNA 27b 0.192272
FKBP4 FK506 binding protein 4, 59kDa 0.192256
C1R complement component 1, r subcomponent 0.19224
CCNC cyclin C 0.192224
NRP1 neuropilin 1 0.192224
JAK1 Janus kinase 1 0.192125
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.192125
RGS16 regulator of G-protein signaling 16 0.192059
IGFBP1 insulin-like growth factor binding protein 1 0.191976
GRPR gastrin-releasing peptide receptor 0.191807
NTF3 neurotrophin 3 0.191444
RGS7 regulator of G-protein signaling 7 0.191427
MMEL1 membrane metallo-endopeptidase-like 1 0.191302
BIRC5 baculoviral IAP repeat containing 5 0.191302
MAPT microtubule-associated protein tau 0.191177
ACTB actin, beta 0.191122
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.191086
PMP22 peripheral myelin protein 22 0.190939
HPSE2 heparanase 2 (inactive) 0.19092
TMSB4X thymosin beta 4, X-linked 0.190883
CP ceruloplasmin (ferroxidase) 0.190562
TRPC7 transient receptor potential cation channel, subfamily C, member 7 0.190524
CAST calpastatin 0.190466
LEPR leptin receptor 0.190466
COL18A1 collagen, type XVIII, alpha 1 0.190466
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.190271
HOXB2 homeobox B2 0.190271
CDK4 cyclin-dependent kinase 4 0.190052
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.189971
PISD phosphatidylserine decarboxylase 0.189829
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.189829