osteonecrosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Death of a bone or part of a bone, either atraumatic or posttraumatic. (Experimental Factor Ontology, EFO_0004259)
Similar Terms
Downloads & Tools

Genes

160 genes co-occuring with the disease osteonecrosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
BGLAP bone gamma-carboxyglutamate (gla) protein 1.4755
BMP2 bone morphogenetic protein 2 1.4733
ALPPL2 alkaline phosphatase, placental-like 2 1.26429
ALPP alkaline phosphatase, placental 1.26342
ALPL alkaline phosphatase, liver/bone/kidney 1.26298
F5 coagulation factor V (proaccelerin, labile factor) 1.26124
RUNX2 runt-related transcription factor 2 1.24819
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.21262
PROS1 protein S (alpha) 1.09755
ZNF28 zinc finger protein 28 1.0816
ZNF461 zinc finger protein 461 1.0816
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.07488
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.07236
PTH parathyroid hormone 1.06648
GBA glucosidase, beta, acid 1.03282
CYP27C1 cytochrome P450, family 27, subfamily C, polypeptide 1 1.03282
EGFL6 EGF-like-domain, multiple 6 1.00625
PLG plasminogen 1.00499
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.997392
F2 coagulation factor II (thrombin) 0.986849
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.97128
COL2A1 collagen, type II, alpha 1 0.954525
VEGFA vascular endothelial growth factor A 0.932898
ZNF71 zinc finger protein 71 0.927932
DLK2 delta-like 2 homolog (Drosophila) 0.906086
SCAND1 SCAN domain containing 1 0.904854
BMP7 bone morphogenetic protein 7 0.904442
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 0.882701
GPR26 G protein-coupled receptor 26 0.874919
SOST sclerostin 0.857315
CBY3 chibby homolog 3 (Drosophila) 0.842982
EGFL8 EGF-like-domain, multiple 8 0.835607
FDPS farnesyl diphosphate synthase 0.831918
PLAT plasminogen activator, tissue 0.802385
CALCA calcitonin-related polypeptide alpha 0.786803
RBMS3 RNA binding motif, single stranded interacting protein 3 0.782298
AMIGO2 adhesion molecule with Ig-like domain 2 0.749237
PPARG peroxisome proliferator-activated receptor gamma 0.747204
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.739082
PRR20C proline rich 20C 0.721673
PRR20E proline rich 20E 0.721673
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.720865
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.716021
ACPP acid phosphatase, prostate 0.714005
PRR20A proline rich 20A 0.698715
P3H2 prolyl 3-hydroxylase 2 0.654858
DNTT DNA nucleotidylexotransferase 0.640645
PLAC8 placenta-specific 8 0.616703
WNT3A wingless-type MMTV integration site family, member 3A 0.60225
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.598351
CTSK cathepsin K 0.567609
SP7 Sp7 transcription factor 0.557509
CD4 CD4 molecule 0.547419
SMAD7 SMAD family member 7 0.535022
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.534635
NARF nuclear prelamin A recognition factor 0.533861
COL1A1 collagen, type I, alpha 1 0.532314
MSX1 msh homeobox 1 0.529608
TPRG1L tumor protein p63 regulated 1-like 0.528449
ASRGL1 asparaginase like 1 0.524202
FAM120A family with sequence similarity 120A 0.520731
VWF von Willebrand factor 0.51611
SON SON DNA binding protein 0.496175
LRP5 low density lipoprotein receptor-related protein 5 0.478668
F3 coagulation factor III (thromboplastin, tissue factor) 0.477909
F8 coagulation factor VIII, procoagulant component 0.476772
CHIT1 chitinase 1 (chitotriosidase) 0.46466
HBD hemoglobin, delta 0.463149
MYDGF myeloid-derived growth factor 0.445052
PON1 paraoxonase 1 0.440162
MATR3 matrin 3 0.43941
ACP5 acid phosphatase 5, tartrate resistant 0.433397
ERCC8 excision repair cross-complementation group 8 0.40904
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 0.404931
PGRMC1 progesterone receptor membrane component 1 0.398216
SIK1 salt-inducible kinase 1 0.396353
FBL fibrillarin 0.395235
IL33 interleukin 33 0.389653
ANXA2 annexin A2 0.389653
CCDC34 coiled-coil domain containing 34 0.379626
TLR4 toll-like receptor 4 0.371847
HBB hemoglobin, beta 0.369258
NELL1 NEL-like 1 (chicken) 0.364085
ESR1 estrogen receptor 1 0.363716
HBA2 hemoglobin, alpha 2 0.358551
TBX1 T-box 1 0.357077
APOB apolipoprotein B 0.342739
GP9 glycoprotein IX (platelet) 0.341272
DPYS dihydropyrimidinase 0.341272
VEGFC vascular endothelial growth factor C 0.341272
FBLL1 fibrillarin-like 1 0.340906
IL17A interleukin 17A 0.337608
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 0.335046
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.334681
SREBF2 sterol regulatory element binding transcription factor 2 0.326646
NOS3 nitric oxide synthase 3 (endothelial cell) 0.323002
NCOA2 nuclear receptor coactivator 2 0.323002
NPPC natriuretic peptide C 0.32009
HBG2 hemoglobin, gamma G 0.319363
HBA1 hemoglobin, alpha 1 0.309566
A1BG alpha-1-B glycoprotein 0.309204
BMP4 bone morphogenetic protein 4 0.308842
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.30848
IL31RA interleukin 31 receptor A 0.304503
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.301254
CHRND cholinergic receptor, nicotinic, delta (muscle) 0.301254
C4B complement component 4B (Chido blood group) 0.300173
EGFL7 EGF-like-domain, multiple 7 0.295851
EPHB1 EPH receptor B1 0.294772
PRKCD protein kinase C, delta 0.293694
PDGFB platelet-derived growth factor beta polypeptide 0.293334
FGF2 fibroblast growth factor 2 (basic) 0.29118
ANXA5 annexin A5 0.287593
DCSTAMP dendrocyte expressed seven transmembrane protein 0.263722
DSG1 desmoglein 1 0.257711
METTL13 methyltransferase like 13 0.25207
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 0.246098
ACAN aggrecan 0.243995
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.242595
WNT3 wingless-type MMTV integration site family, member 3 0.239799
CCL5 chemokine (C-C motif) ligand 5 0.232489
APOA1 apolipoprotein A-I 0.230755
ANXA6 annexin A6 0.22937
MMD monocyte to macrophage differentiation-associated 0.224884
SATB2 SATB homeobox 2 0.218715
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 0.217352
HYOU1 hypoxia up-regulated 1 0.209248
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.208245
CRP C-reactive protein, pentraxin-related 0.207912
CD34 CD34 molecule 0.20658
MMP8 matrix metallopeptidase 8 0.206248
WDFY2 WD repeat and FYVE domain containing 2 0.205585
CALCOCO2 calcium binding and coiled-coil domain 2 0.203933
ULK1 unc-51 like autophagy activating kinase 1 0.201962
IL1B interleukin 1, beta 0.200982
DLX5 distal-less homeobox 5 0.199033
CNR2 cannabinoid receptor 2 (macrophage) 0.194865
MYD88 myeloid differentiation primary response 88 0.191408
ACP1 acid phosphatase 1, soluble 0.191097
POSTN periostin, osteoblast specific factor 0.191097
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.190786
ZFPM1 zinc finger protein, FOG family member 1 0.183835
SIX2 SIX homeobox 2 0.175679
FGF7 fibroblast growth factor 7 0.174617
RAP1A RAP1A, member of RAS oncogene family 0.173571
COMP cartilage oligomeric matrix protein 0.173314
WNT10B wingless-type MMTV integration site family, member 10B 0.172544
NBL1 neuroblastoma 1, DAN family BMP antagonist 0.171286
CCL4 chemokine (C-C motif) ligand 4 0.170054
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.169091
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 0.168854
FHL1 four and a half LIM domains 1 0.168148
SCG2 secretogranin II 0.166544
IL23R interleukin 23 receptor 0.164571
EPHB3 EPH receptor B3 0.162908
SEPT4 septin 4 0.162707
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.160203
RNF112 ring finger protein 112 0.158951
WDR11 WD repeat domain 11 0.158434
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.157765