osteopenia Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Osteopenia refers to a reduction in bone mineral density (BMD) below normal peak BMD but not low enough to be classified as osteoporosis. According to the WHO, osteopenia is characterized by a value of BMD more than 1 standard deviation below the young adult mean, but less than 2 standard deviations below this value. (Human Phenotype Ontology, HP_0000938)
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Genes

31 genes co-occuring with the biological term osteopenia in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ALPL alkaline phosphatase, liver/bone/kidney
APOA1 apolipoprotein A-I
APOE apolipoprotein E
BGLAP bone gamma-carboxyglutamate (gla) protein
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CA1 carbonic anhydrase I
CCL2 chemokine (C-C motif) ligand 2
CCR2 chemokine (C-C motif) receptor 2
CD40 CD40 molecule, TNF receptor superfamily member 5
COL15A1 collagen, type XV, alpha 1
CTSC cathepsin C
CXCL12 chemokine (C-X-C motif) ligand 12
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPT dermatopontin
EDN1 endothelin 1
GREM1 gremlin 1, DAN family BMP antagonist
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IL6 interleukin 6
LEP leptin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
PGK1 phosphoglycerate kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPARG peroxisome proliferator-activated receptor gamma
SDF4 stromal cell derived factor 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WISP2 WNT1 inducible signaling pathway protein 2