osteoporosis Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis. (Experimental Factor Ontology, EFO_0003882)
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Genes

128 genes associated with the disease osteoporosis in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 1.75714
MEPE matrix extracellular phosphoglycoprotein 1.65491
FAM3C family with sequence similarity 3, member C 1.65491
LRP5 low density lipoprotein receptor-related protein 5 1.61356
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.57113
C17ORF53 chromosome 17 open reading frame 53 1.53808
FUBP3 far upstream element (FUSE) binding protein 3 1.45684
JAG1 jagged 1 1.31515
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 1.30486
SMG6 SMG6 nonsense mediated mRNA decay factor 1.2894
C2ORF73 chromosome 2 open reading frame 73 1.27521
AKAP11 A kinase (PRKA) anchor protein 11 1.22898
CLCN7 chloride channel, voltage-sensitive 7 1.17894
WNT4 wingless-type MMTV integration site family, member 4 1.17894
AXIN1 axin 1 1.17894
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 1.14929
MARK3 MAP/microtubule affinity-regulating kinase 3 1.11998
HOXC4 homeobox C4 1.10381
HOXC6 homeobox C6 1.10381
WNT16 wingless-type MMTV integration site family, member 16 1.09588
DHH desert hedgehog 1.09588
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 1.07383
IDUA iduronidase, alpha-L- 1.04495
COLEC10 collectin sub-family member 10 (C-type lectin) 1.03485
DNM3 dynamin 3 1.02774
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.00628
MEF2C myocyte enhancer factor 2C 0.965481
WLS wntless Wnt ligand secretion mediator 0.932337
NME8 NME/NM23 family member 8 0.910378
GPR141 G protein-coupled receptor 141 0.910378
KLHL42 kelch-like family member 42 0.872896
RPS12 ribosomal protein S12 0.85991
LEKR1 leucine, glutamate and lysine rich 1 0.850113
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.842276
DCDC5 doublecortin domain containing 5 0.790827
SOX9 SRY (sex determining region Y)-box 9 0.790827
MAPT microtubule-associated protein tau 0.752991
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.745324
GPATCH1 G patch domain containing 1 0.738873
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.724323
CPED1 cadherin-like and PC-esterase domain containing 1 0.724323
INSIG2 insulin induced gene 2 0.724323
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.69843
TRHR thyrotropin-releasing hormone receptor 0.670996
KIAA2018 KIAA2018 0.670996
CPN1 carboxypeptidase N, polypeptide 1 0.63666
CCDC170 coiled-coil domain containing 170 0.63207
PKDCC protein kinase domain containing, cytoplasmic 0.63207
TMEM263 transmembrane protein 263 0.63207
SFRP4 secreted frizzled-related protein 4 0.63207
FMN2 formin 2 0.602429
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.602429
ANAPC1 anaphase promoting complex subunit 1 0.602429
DCDC1 doublecortin domain containing 1 0.602429
ARHGAP1 Rho GTPase activating protein 1 0.572184
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 0.544585
CRHR1 corticotropin releasing hormone receptor 1 0.52461
SPTBN1 spectrin, beta, non-erythrocytic 1 0.486425
ESR1 estrogen receptor 1 0.486425
GLYAT glycine-N-acyltransferase 0.486425
C2ORF69 chromosome 2 open reading frame 69 0.486425
HDAC5 histone deacetylase 5 0.486425
SOST sclerostin 0.486425
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 0.486425
RSPO3 R-spondin 3 0.464771
MECOM MDS1 and EVI1 complex locus 0.449873
RAP1A RAP1A, member of RAS oncogene family 0.449873
LIN7C lin-7 homolog C (C. elegans) 0.438544
MIMS1 mitochondrial inner membrane scaffold 1 0.438544
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.403461
SP7 Sp7 transcription factor 0.403461
NRG1 neuregulin 1 0.368757
ADGRV1 adhesion G protein-coupled receptor V1 0.368757
XKR9 XK, Kell blood group complex subunit-related family, member 9 0.368757
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.345945
PLCL1 phospholipase C-like 1 0.345945
FAR1 fatty acyl CoA reductase 1 0.327313
OSBPL1A oxysterol binding protein-like 1A 0.327313
SOX6 SRY (sex determining region Y)-box 6 0.327313
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.297866
DLG2 discs, large homolog 2 (Drosophila) 0.285417
CKAP5 cytoskeleton associated protein 5 0.285417
IBSP integrin-binding sialoprotein 0.274608
TOP2B topoisomerase (DNA) II beta 180kDa 0.264872
DOK6 docking protein 6 0.264872
CTNNBL1 catenin, beta like 1 0.256228
LMX1A LIM homeobox transcription factor 1, alpha 0.256228
NGLY1 N-glycanase 1 0.256228
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.256228
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 0.256228
TGFBR3 transforming growth factor, beta receptor III 0.256228
IL1RAP interleukin 1 receptor accessory protein 0.256228
FRMD4B FERM domain containing 4B 0.197766
TMEM182 transmembrane protein 182 0.197766
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.197766
IL21R interleukin 21 receptor 0.197766
BMS1 BMS1 ribosome biogenesis factor 0.197766
PARP4 poly (ADP-ribose) polymerase family, member 4 0.197766
UMOD uromodulin 0.197766
NPY neuropeptide Y 0.197766
ZNF518B zinc finger protein 518B 0.197766
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.15771
CNTNAP2 contactin associated protein-like 2 0.15771
RBMS3 RNA binding motif, single stranded interacting protein 3 0.15771
POSTN periostin, osteoblast specific factor 0.15771
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.15771
CASKIN2 CASK interacting protein 2 0.15771
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 0.15771
PHACTR1 phosphatase and actin regulator 1 0.15771
CADM1 cell adhesion molecule 1 0.15771
HK2 hexokinase 2 0.15771
PDK1 pyruvate dehydrogenase kinase, isozyme 1 0.126165
FGF14 fibroblast growth factor 14 0.126165
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.126165
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.126165
SCG2 secretogranin II 0.126165
IL12B interleukin 12B 0.100789
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.100789
PLD5 phospholipase D family, member 5 0.100789
C9ORF92 chromosome 9 open reading frame 92 0.080593
HSPA13 heat shock protein 70kDa family, member 13 0.080593
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.064973
KIAA1217 KIAA1217 0.064973
SAXO1 stabilizer of axonemal microtubules 1 0.052255
ETV5 ets variant 5 0.052255
TBX20 T-box 20 0.043246
FREM1 FRAS1 related extracellular matrix 1 0.043246
PABPC4L poly(A) binding protein, cytoplasmic 4-like 0.035343