osteoporosis Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis. (Experimental Factor Ontology, EFO_0003882)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:11476
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Genes

132 genes associated with the disease osteoporosis in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
MCM8 minichromosome maintenance complex component 8 2.81923
TMEM150B transmembrane protein 150B 2.65928
UIMC1 ubiquitin interaction motif containing 1 2.29954
HELQ helicase, POLQ-like 1.98052
PRIM1 primase, DNA, polypeptide 1 (49kDa) 1.98052
BRSK1 BR serine/threonine kinase 1 1.98052
RHBDL2 rhomboid, veinlet-like 2 (Drosophila) 1.88168
PRRC2A proline-rich coiled-coil 2A 1.86468
LIN28B lin-28 homolog B (C. elegans) 1.85286
ZNF483 zinc finger protein 483 1.81775
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 1.79076
TLK1 tousled-like kinase 1 1.77455
RXRG retinoid X receptor, gamma 1.74
SKOR2 SKI family transcriptional corepressor 2 1.7256
POLG polymerase (DNA directed), gamma 1.71314
FNDC4 fibronectin type III domain containing 4 1.68078
SYCP2L synaptonemal complex protein 2-like 1.64426
TDRD3 tudor domain containing 3 1.57556
CCDC85A coiled-coil domain containing 85A 1.57556
TRHR thyrotropin-releasing hormone receptor 1.53704
EXO1 exonuclease 1 1.51636
NLRP11 NLR family, pyrin domain containing 11 1.51254
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 1.48714
CRTC1 CREB regulated transcription coactivator 1 1.4479
GAB2 GRB2-associated binding protein 2 1.43537
BEGAIN brain-enriched guanylate kinase-associated 1.42467
TRIM66 tripartite motif containing 66 1.42467
RBM6 RNA binding motif protein 6 1.39396
FTCDNL1 formiminotransferase cyclodeaminase N-terminal like 1.39396
COL4A2 collagen, type IV, alpha 2 1.38272
METAP1D methionyl aminopeptidase type 1D (mitochondrial) 1.37519
FTO fat mass and obesity associated 1.37327
KLHDC8B kelch domain containing 8B 1.37327
RAP1A RAP1A, member of RAS oncogene family 1.35834
MECOM MDS1 and EVI1 complex locus 1.35834
NRCAM neuronal cell adhesion molecule 1.34719
KDM3B lysine (K)-specific demethylase 3B 1.34719
NUSAP1 nucleolar and spindle associated protein 1 1.34719
PHF21A PHD finger protein 21A 1.33878
KPNA3 karyopherin alpha 3 (importin alpha 4) 1.32087
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 1.31635
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific 1.31635
AKT3 v-akt murine thymoma viral oncogene homolog 3 1.31635
AKAP6 A kinase (PRKA) anchor protein 6 1.30364
LRP1B low density lipoprotein receptor-related protein 1B 1.28906
BANP BTG3 associated nuclear protein 1.28906
OLFM2 olfactomedin 2 1.28906
FADS1 fatty acid desaturase 1 1.28906
PNP purine nucleoside phosphorylase 1.27473
ECE2 endothelin converting enzyme 2 1.26953
ADGRA2 adhesion G protein-coupled receptor A2 1.26953
SLC14A2 solute carrier family 14 (urea transporter), member 2 1.26953
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 1.25677
SOX6 SRY (sex determining region Y)-box 6 1.25477
OSBPL1A oxysterol binding protein-like 1A 1.25477
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.25477
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 1.24289
SLC44A4 solute carrier family 44, member 4 1.24194
TLE4 transducin-like enhancer of split 4 1.23666
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 1.21996
RORA RAR-related orphan receptor A 1.21019
DOK6 docking protein 6 1.20161
TNR tenascin R 1.19518
TACR3 tachykinin receptor 3 1.19386
TRAF3IP2-AS1 TRAF3IP2 antisense RNA 1 1.14798
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 1.14463
KIRREL3 kin of IRRE like 3 (Drosophila) 1.14463
FLJ32955 1.14463
IQCH IQ motif containing H 1.14463
PLCL1 phospholipase C-like 1 1.14463
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 1.10764
DSCAML1 Down syndrome cell adhesion molecule like 1 1.10764
UNC13C unc-13 homolog C (C. elegans) 1.10764
C12ORF40 chromosome 12 open reading frame 40 1.0908
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 1.09022
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 1.08598
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 1.07599
WDFY4 WDFY family member 4 1.07052
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 1.04846
ZFHX4 zinc finger homeobox 4 1.04846
ANTXR1 anthrax toxin receptor 1 1.02945
RNF44 ring finger protein 44 1.02476
CHN2 chimerin 2 1.00577
NKX2-1 NK2 homeobox 1 1.00407
TBC1D22A TBC1 domain family, member 22A 0.998024
KRT82 keratin 82, type II 0.981879
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.95603
VCAN versican 0.948266
MYO16 myosin XVI 0.942098
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 0.939181
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 0.939181
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 0.938237
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.920453
NUDCD1 NudC domain containing 1 0.91969
PRDM5 PR domain containing 5 0.918934
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.918185
FAM159A family with sequence similarity 159, member A 0.855811
OFCC1 orofacial cleft 1 candidate 1 0.855811
KRT84 keratin 84, type II 0.855302
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.839855
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.837296
SLIT2 slit homolog 2 (Drosophila) 0.819929
CSMD2 CUB and Sushi multiple domains 2 0.818364
TASP1 taspase, threonine aspartase, 1 0.817977
NXPH1 neurexophilin 1 0.810532
NCKAP5 NCK-associated protein 5 0.80598
DNAH9 dynein, axonemal, heavy chain 9 0.80598
OPCML opioid binding protein/cell adhesion molecule-like 0.804621
OTOGL otogelin-like 0.79774
DAZAP1 DAZ associated protein 1 0.794247
LRRC41 leucine rich repeat containing 41 0.772631
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 0.764084
F13A1 coagulation factor XIII, A1 polypeptide 0.757405
EEF1DP3 eukaryotic translation elongation factor 1 delta pseudogene 3 0.756331
ATP10B ATPase, class V, type 10B 0.756064
DEXI Dexi homolog (mouse) 0.753433
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.706073
PADI2 peptidyl arginine deiminase, type II 0.693888
SAMD12 sterile alpha motif domain containing 12 0.681256
PBX1 pre-B-cell leukemia homeobox 1 0.677839
MCTP1 multiple C2 domains, transmembrane 1 0.676173
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 0.67576
THSD4 thrombospondin, type I, domain containing 4 0.67359
PCDH9 protocadherin 9 0.669646
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.612357
ZRANB2-AS2 ZRANB2 antisense RNA 2 (head to head) 0.601018
PARK2 parkin RBR E3 ubiquitin protein ligase 0.598248
WRN Werner syndrome, RecQ helicase-like 0.580521
ARHGAP22 Rho GTPase activating protein 22 0.578411
PRIMPOL primase and polymerase (DNA-directed) 0.551704
PRPF31 pre-mRNA processing factor 31 0.528409
EGF epidermal growth factor 0.500861