osteoporosis Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis. (Experimental Factor Ontology, EFO_0003882)
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Genes

144 genes co-occuring with the biological term osteoporosis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB2 adrenoceptor beta 2, surface
AHSG alpha-2-HS-glycoprotein
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALOX15 arachidonate 15-lipoxygenase
ALPL alkaline phosphatase, liver/bone/kidney
ANKH ANKH inorganic pyrophosphate transport regulator
ANXA2 annexin A2
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATF6 activating transcription factor 6
BGLAP bone gamma-carboxyglutamate (gla) protein
BIRC2 baculoviral IAP repeat containing 2
BMP2 bone morphogenetic protein 2
BMP2K BMP2 inducible kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CA10 carbonic anhydrase X
CA8 carbonic anhydrase VIII
CALCR calcitonin receptor
CCL2 chemokine (C-C motif) ligand 2
CCR2 chemokine (C-C motif) receptor 2
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CDX2 caudal type homeobox 2
CER1 cerberus 1, DAN family BMP antagonist
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
COL1A1 collagen, type I, alpha 1
CST3 cystatin C
CTSK cathepsin K
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DCAF13 DDB1 and CUL4 associated factor 13
DKK1 dickkopf WNT signaling pathway inhibitor 1
DVL2 dishevelled segment polarity protein 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FGF23 fibroblast growth factor 23
FGFBP1 fibroblast growth factor binding protein 1
FRZB frizzled-related protein
FSHB follicle stimulating hormone, beta polypeptide
FTCDNL1 formiminotransferase cyclodeaminase N-terminal like
FTO fat mass and obesity associated
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GC group-specific component (vitamin D binding protein)
GH1 growth hormone 1
GHR growth hormone receptor
GPR68 G protein-coupled receptor 68
GREM2 gremlin 2, DAN family BMP antagonist
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HP haptoglobin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ICAM1 intercellular adhesion molecule 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IL10 interleukin 10
IL15 interleukin 15
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
INSL3 insulin-like 3 (Leydig cell)
IRS2 insulin receptor substrate 2
ITGA1 integrin, alpha 1
JAG1 jagged 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LCT lactase
LEP leptin
LEPQTL1 Leptin, serum levels of
LEPR leptin receptor
LRP4 low density lipoprotein receptor-related protein 4
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
LTF lactotransferrin
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MBL2 mannose-binding lectin (protein C) 2, soluble
MIR21 microRNA 21
MIR2861 microRNA 2861
MIR503 microRNA 503
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NOTCH2 notch 2
NOX4 NADPH oxidase 4
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PDLIM4 PDZ and LIM domain 4
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PLS3 plastin 3
POMC proopiomelanocortin
PON1 paraoxonase 1
PTH parathyroid hormone
PTHLH parathyroid hormone-like hormone
PTK2B protein tyrosine kinase 2 beta
PTN pleiotrophin
QPCT glutaminyl-peptide cyclotransferase
RNF185 ring finger protein 185
RUNX2 runt-related transcription factor 2
RXFP2 relaxin/insulin-like family peptide receptor 2
SAA1 serum amyloid A1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SHBG sex hormone-binding globulin
SIRT1 sirtuin 1
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SNX10 sorting nexin 10
SOD2 superoxide dismutase 2, mitochondrial
SOST sclerostin
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STAT1 signal transducer and activator of transcription 1, 91kDa
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
THSD4 thrombospondin, type I, domain containing 4
THSD7A thrombospondin, type I, domain containing 7A
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TSC22D3 TSC22 domain family, member 3
TWIST1 twist family bHLH transcription factor 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VKORC1 vitamin K epoxide reductase complex, subunit 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WNK4 WNK lysine deficient protein kinase 4
WNT3A wingless-type MMTV integration site family, member 3A