osteoporosis Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A bone resorption disease that has_material_basis_in a drop in estrogen or testosterone which results_in the thinning of bone tissue and loss of bone mineral density. (Human Disease Ontology, DOID_11476)
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Genes

145 genes associated with the disease osteoporosis in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ADCY10 adenylate cyclase 10 (soluble)
AKAP7 A kinase (PRKA) anchor protein 7
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALDH9A1 aldehyde dehydrogenase 9 family, member A1
AR androgen receptor
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
BGLAP bone gamma-carboxyglutamate (gla) protein
BLZF1 basic leucine zipper nuclear factor 1
BMP4 bone morphogenetic protein 4
C1ORF112 chromosome 1 open reading frame 112
CA10 carbonic anhydrase X
CA2 carbonic anhydrase II
CA8 carbonic anhydrase VIII
CALCR calcitonin receptor
CCDC148 coiled-coil domain containing 148
CCDC27 coiled-coil domain containing 27
CD247 CD247 molecule
CD38 CD38 molecule
CDC73 cell division cycle 73
CHM choroideremia (Rab escort protein 1)
CLCN7 chloride channel, voltage-sensitive 7
CLINT1 clathrin interactor 1
CNOT6 CCR4-NOT transcription complex, subunit 6
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
CNTNAP2 contactin associated protein-like 2
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
CREG1 cellular repressor of E1A-stimulated genes 1
CRTAP cartilage associated protein
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTSK cathepsin K
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DCAF6 DDB1 and CUL4 associated factor 6
DMD dystrophin
DOK6 docking protein 6
DPT dermatopontin
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F5 coagulation factor V (proaccelerin, labile factor)
FAM135B family with sequence similarity 135, member B
FAM78B family with sequence similarity 78, member B
FBXO5 F-box protein 5
FDPS farnesyl diphosphate synthase
FGF2 fibroblast growth factor 2 (basic)
FLNB filamin B, beta
GHR growth hormone receptor
GHRH growth hormone releasing hormone
GHRHR growth hormone releasing hormone receptor
GHSR growth hormone secretagogue receptor
GPA33 glycoprotein A33 (transmembrane)
GPR161 G protein-coupled receptor 161
HK2 hexokinase 2
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA4L heat shock 70kDa protein 4-like
IL1RN interleukin 1 receptor antagonist
ILDR2 immunoglobulin-like domain containing receptor 2
ISG15 ISG15 ubiquitin-like modifier
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5
KIFAP3 kinesin-associated protein 3
LMX1A LIM homeobox transcription factor 1, alpha
LOC284685 EWS RNA-binding protein 1 pseudogene
LRP1B low density lipoprotein receptor-related protein 1B
LRP4 low density lipoprotein receptor-related protein 4
LRP5 low density lipoprotein receptor-related protein 5
LRRC52 leucine rich repeat containing 52
MAEL maelstrom spermatogenic transposon silencer
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARK3 MAP/microtubule affinity-regulating kinase 3
METTL18 methyltransferase like 18
MGST3 microsomal glutathione S-transferase 3
MPC2 mitochondrial pyruvate carrier 2
MPZL1 myelin protein zero-like 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NME7 NME/NM23 family member 7
NOG noggin
NOS3 nitric oxide synthase 3 (endothelial cell)
NR5A2 nuclear receptor subfamily 5, group A, member 2
NRG1 neuregulin 1
OR4D10 olfactory receptor, family 4, subfamily D, member 10
OSBPL1A oxysterol binding protein-like 1A
PBX1 pre-B-cell leukemia homeobox 1
PGR progesterone receptor
PIBF1 progesterone immunomodulatory binding factor 1
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
POGK pogo transposable element with KRAB domain
POU2F1 POU class 2 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PTH parathyroid hormone
PTH1R parathyroid hormone 1 receptor
RAP1A RAP1A, member of RAS oncogene family
RCSD1 RCSD domain containing 1
RERE arginine-glutamic acid dipeptide (RE) repeats
RUNX2 runt-related transcription factor 2
RXRG retinoid X receptor, gamma
SCYL3 SCY1-like 3 (S. cerevisiae)
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SFRP1 secreted frizzled-related protein 1
SFT2D2 SFT2 domain containing 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SLIT3 slit homolog 3 (Drosophila)
SOST sclerostin
SOX6 SRY (sex determining region Y)-box 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTBN1 spectrin, beta, non-erythrocytic 1
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)
STAT1 signal transducer and activator of transcription 1, 91kDa
TADA1 transcriptional adaptor 1
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TBX19 T-box 19
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TDGF1 teratocarcinoma-derived growth factor 1
TERC telomerase RNA component
TGFB1 transforming growth factor, beta 1
TIPRL TOR signaling pathway regulator
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TPD52 tumor protein D52
UCK2 uridine-cytidine kinase 2
UMOD uromodulin
USO1 USO1 vesicle transport factor
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VNN1 vanin 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WIF1 WNT inhibitory factor 1
WLS wntless Wnt ligand secretion mediator
XCL1 chemokine (C motif) ligand 1
ZBTB40 zinc finger and BTB domain containing 40
ZCCHC6 zinc finger, CCHC domain containing 6
ZNF239 zinc finger protein 239