osteosarcoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)|A malignant mesenchymal tumor arising from the bone.|A usually aggressive malignant bone-forming mesenchymal tumor, predominantly affecting adolescents and young adults. It usually involves bones and less frequently extraosseous sites. It often involves the long bones (particularly distal femur, proximal tibia, and proximal humerus). Pain with or without a palpable mass is the most frequent clinical symptom. It may spread to other anatomic sites, particularly the lungs. (Experimental Factor Ontology, EFO_0000637)
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Genes

323 genes co-occuring with the disease osteosarcoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ALPPL2 alkaline phosphatase, placental-like 2 1.33589
ALPP alkaline phosphatase, placental 1.33545
ALPL alkaline phosphatase, liver/bone/kidney 1.32629
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 1.32061
COPS3 COP9 signalosome subunit 3 1.30488
RUNX2 runt-related transcription factor 2 1.24863
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.19445
TP53 tumor protein p53 1.15837
GID4 GID complex subunit 4 1.13289
EZR ezrin 1.09713
PLXDC1 plexin domain containing 1 1.09671
BGLAP bone gamma-carboxyglutamate (gla) protein 1.08495
CDC5L cell division cycle 5-like 1.02018
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 1.00372
MMP2 matrix metallopeptidase 2 0.933727
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.932484
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 0.923387
RECQL4 RecQ protein-like 4 0.920911
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.902389
RB1 retinoblastoma 1 0.900335
BMP2 bone morphogenetic protein 2 0.880243
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.880243
FOS FBJ murine osteosarcoma viral oncogene homolog 0.86018
LRRC75A-AS1 LRRC75A antisense RNA 1 0.839296
CYR61 cysteine-rich, angiogenic inducer, 61 0.804846
C20ORF144 chromosome 20 open reading frame 144 0.798282
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 0.793361
CDK4 cyclin-dependent kinase 4 0.788442
MMP9 matrix metallopeptidase 9 0.761862
TP53RK TP53 regulating kinase 0.735433
CLEC2D C-type lectin domain family 2, member D 0.715215
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.693098
ARHGAP44 Rho GTPase activating protein 44 0.691094
SP7 Sp7 transcription factor 0.687891
SKA2 spindle and kinetochore associated complex subunit 2 0.684692
SPP1 secreted phosphoprotein 1 0.682294
ROCK1P1 Rho-associated, coiled-coil containing protein kinase 1 pseudogene 1 0.679499
ARPC5L actin related protein 2/3 complex, subunit 5-like 0.666755
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.642221
PTH parathyroid hormone 0.637495
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.625711
CD99 CD99 molecule 0.622183
IBSP integrin-binding sialoprotein 0.6214
FZD1 frizzled class receptor 1 0.613574
DHFR dihydrofolate reductase 0.60303
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 0.59952
S100A4 S100 calcium binding protein A4 0.579272
ST20 suppressor of tumorigenicity 20 0.577716
JUN jun proto-oncogene 0.574217
RASD1 RAS, dexamethasone-induced 1 0.562558
CAPRIN1 cell cycle associated protein 1 0.557509
SOX9 SRY (sex determining region Y)-box 9 0.55712
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.55712
ZNF395 zinc finger protein 395 0.548195
NMT2 N-myristoyltransferase 2 0.542379
BAX BCL2-associated X protein 0.541605
ERRFI1 ERBB receptor feedback inhibitor 1 0.540829
CCNB3 cyclin B3 0.540055
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.534248
EWSR1 EWS RNA-binding protein 1 0.528835
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.52729
BIRC5 baculoviral IAP repeat containing 5 0.525746
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.522273
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 0.513033
RPL7A ribosomal protein L7a 0.512264
IGF1R insulin-like growth factor 1 receptor 0.507273
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.504973
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.495793
RANGRF RAN guanine nucleotide release factor 0.492359
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.487027
IGF1 insulin-like growth factor 1 (somatomedin C) 0.482464
THBS3 thrombospondin 3 0.482084
GRM4 glutamate receptor, metabotropic 4 0.472604
NOV nephroblastoma overexpressed 0.469954
CDKN2A cyclin-dependent kinase inhibitor 2A 0.468063
EBF2 early B-cell factor 2 0.465038
MTX2 metaxin 2 0.458996
ACPP acid phosphatase, prostate 0.456732
FAXDC2 fatty acid hydroxylase domain containing 2 0.449194
WNT1 wingless-type MMTV integration site family, member 1 0.447687
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 0.445429
CTSF cathepsin F 0.44129
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 0.43941
MED19 mediator complex subunit 19 0.438658
TBR1 T-box, brain, 1 0.438658
SELO selenoprotein O 0.437154
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.436402
IHH indian hedgehog 0.434524
SCIN scinderin 0.431894
ANXA10 annexin A10 0.430768
ST7 suppression of tumorigenicity 7 0.428516
VEGFA vascular endothelial growth factor A 0.424389
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.422515
ING2 inhibitor of growth family, member 2 0.413901
SELM selenoprotein M 0.408292
CCNB1 cyclin B1 0.404557
CREB3L1 cAMP responsive element binding protein 3-like 1 0.40008
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.395608
WNT3A wingless-type MMTV integration site family, member 3A 0.395235
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 0.394118
RHOBTB2 Rho-related BTB domain containing 2 0.393374
FN1 fibronectin 1 0.391513
ROR2 receptor tyrosine kinase-like orphan receptor 2 0.391141
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.390769
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.388909
EPHA2 EPH receptor A2 0.384079
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.384079
IRX2 iroquois homeobox 2 0.379997
EMILIN1 elastin microfibril interfacer 1 0.378885
NOTCH1 notch 1 0.378143
MIR181C microRNA 181c 0.375179
NANOG Nanog homeobox 0.375179
MAPK13 mitogen-activated protein kinase 13 0.374438
NOL9 nucleolar protein 9 0.372958
ERBB2 erb-b2 receptor tyrosine kinase 2 0.372587
CACYBP calcyclin binding protein 0.370368
ACTG2 actin, gamma 2, smooth muscle, enteric 0.368149
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.364454
MAP2K4 mitogen-activated protein kinase kinase 4 0.360764
FASLG Fas ligand (TNF superfamily, member 6) 0.360764
TUSC3 tumor suppressor candidate 3 0.357814
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.353027
HBA2 hemoglobin, alpha 2 0.352659
PTPRC protein tyrosine phosphatase, receptor type, C 0.348246
ING3 inhibitor of growth family, member 3 0.347879
NHP2 NHP2 ribonucleoprotein 0.346777
SOX2 SRY (sex determining region Y)-box 2 0.344941
CTGF connective tissue growth factor 0.343473
BRD7 bromodomain containing 7 0.342006
USP6 ubiquitin specific peptidase 6 0.341272
ZEB1 zinc finger E-box binding homeobox 1 0.33944
MMP1 matrix metallopeptidase 1 0.338707
SPARCL1 SPARC-like 1 (hevin) 0.338341
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.338341
PLK1 polo-like kinase 1 0.337608
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.33651
HOXB3 homeobox B3 0.334681
MIR217 microRNA 217 0.333218
FADD Fas (TNFRSF6)-associated via death domain 0.331391
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.331025
CD226 CD226 molecule 0.326281
RYK receptor-like tyrosine kinase 0.325916
MIR210 microRNA 210 0.32373
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.323365
CCND1 cyclin D1 0.32009
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.317545
CCR1 chemokine (C-C motif) receptor 1 0.316092
RB1CC1 RB1-inducible coiled-coil 1 0.31464
HBA1 hemoglobin, alpha 1 0.314278
LRP5 low density lipoprotein receptor-related protein 5 0.314278
RBBP9 retinoblastoma binding protein 9 0.312827
TRIP10 thyroid hormone receptor interactor 10 0.308118
MTDH metadherin 0.307395
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 0.30631
FRZB frizzled-related protein 0.305587
KYNU kynureninase 0.304503
ANXA2 annexin A2 0.303781
ATXN3 ataxin 3 0.303059
COPA coatomer protein complex, subunit alpha 0.302337
WWOX WW domain containing oxidoreductase 0.299812
HES1 hes family bHLH transcription factor 1 0.296211
GAK cyclin G associated kinase 0.295851
CALCR calcitonin receptor 0.294053
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.293334
GNRH2 gonadotropin-releasing hormone 2 0.289744
TAS1R1 taste receptor, type 1, member 1 0.289386
HOXC6 homeobox C6 0.283655
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.281868
MMP7 matrix metallopeptidase 7 0.279011
EFNB3 ephrin-B3 0.278297
FOSL1 FOS-like antigen 1 0.274732
AXIN2 axin 2 0.274021
WNT5B wingless-type MMTV integration site family, member 5B 0.270464
ECT2 epithelial cell transforming 2 0.267267
IGFBP5 insulin-like growth factor binding protein 5 0.266558
TIMP1 TIMP metallopeptidase inhibitor 1 0.266558
ATG7 autophagy related 7 0.265494
PCNA proliferating cell nuclear antigen 0.264431
TPR translocated promoter region, nuclear basket protein 0.257711
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 0.256652
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.251015
COL5A2 collagen, type V, alpha 2 0.248203
ZEB2 zinc finger E-box binding homeobox 2 0.244345
CCND2 cyclin D2 0.242945
ADD3 adducin 3 (gamma) 0.241546
PRND prion protein 2 (dublet) 0.23945
RRAS related RAS viral (r-ras) oncogene homolog 0.235964
RDX radixin 0.23492
PHEX phosphate regulating endopeptidase homolog, X-linked 0.232836
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.230755
ZFX zinc finger protein, X-linked 0.227988
MOGS mannosyl-oligosaccharide glucosidase 0.223165
GDF2 growth differentiation factor 2 0.222136
MAPK7 mitogen-activated protein kinase 7 0.21974
KDR kinase insert domain receptor 0.218715
ENO2 enolase 2 (gamma, neuronal) 0.212945
PRKCD protein kinase C, delta 0.211597
CALD1 caldesmon 1 0.211597
WASF3 WAS protein family, member 3 0.210253
ERCC5 excision repair cross-complementation group 5 0.207912
AATF apoptosis antagonizing transcription factor 0.207578
TIMP2 TIMP metallopeptidase inhibitor 2 0.207245
CDK1 cyclin-dependent kinase 1 0.206913
PDCD5 programmed cell death 5 0.203933
PEG3 paternally expressed 3 0.201962
MXI1 MAX interactor 1, dimerization protein 0.201308
CD44 CD44 molecule (Indian blood group) 0.200982
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.199681
CDC25C cell division cycle 25C 0.195501
GLS glutaminase 0.195183
TGFB2 transforming growth factor, beta 2 0.193915
COL18A1 collagen, type XVIII, alpha 1 0.193915
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.1936
NOTCH2 notch 2 0.1936
CD34 CD34 molecule 0.191408
NOTCH2NL notch 2 N-terminal like 0.191097
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.189859
MIR15B microRNA 15b 0.189551
WNT5A wingless-type MMTV integration site family, member 5A 0.188938
SOS1 son of sevenless homolog 1 (Drosophila) 0.187719
MSN moesin 0.186811
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.18621
TERF2 telomeric repeat binding factor 2 0.182666
EGFR epidermal growth factor receptor 0.18151
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.180084
MT2A metallothionein 2A 0.177851
ILK integrin-linked kinase 0.177851
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.177029
LIN28B lin-28 homolog B (C. elegans) 0.176757
TOP2B topoisomerase (DNA) II beta 180kDa 0.174354
DLC1 DLC1 Rho GTPase activating protein 0.171286
NGDN neuroguidin, EIF4E binding protein 0.171036
BGN biglycan 0.170544
SATB1 SATB homeobox 1 0.170054
TNC tenascin C 0.168854
HOPX HOP homeobox 0.167915
EPHA3 EPH receptor A3 0.165655
MIR214 microRNA 214 0.165655
NRP2 neuropilin 2 0.164786
CCNG1 cyclin G1 0.164786
BCL2A1 BCL2-related protein A1 0.164571
TNXB tenascin XB 0.162109
ULK1 unc-51 like autophagy activating kinase 1 0.162109
CXCL12 chemokine (C-X-C motif) ligand 12 0.161716
NOG noggin 0.161523
HMGB1 high mobility group box 1 0.160948
ING1 inhibitor of growth family, member 1 0.160574
WNT7A wingless-type MMTV integration site family, member 7A 0.160387
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.159302
SLC19A1 solute carrier family 19 (folate transporter), member 1 0.158951
RING1 ring finger protein 1 0.158097
POLL polymerase (DNA directed), lambda 0.157929
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.157765
CHMP2A charged multivesicular body protein 2A 0.138892
DUX4L8 double homeobox 4 like 8 0.138435
BCOR BCL6 corepressor 0.138348
DUX4L6 double homeobox 4 like 6 0.137768
LGALS1 lectin, galactoside-binding, soluble, 1 0.135133
SYP synaptophysin 0.133696
FLI1 Fli-1 proto-oncogene, ETS transcription factor 0.132965
KRT8 keratin 8, type II 0.13265
WDFY2 WD repeat and FYVE domain containing 2 0.132491
FABP3 fatty acid binding protein 3, muscle and heart 0.131524
PDLIM7 PDZ and LIM domain 7 (enigma) 0.130183
IGF2 insulin-like growth factor 2 0.128482
GNAS GNAS complex locus 0.127152
MDM4 MDM4, p53 regulator 0.125295
CYCS cytochrome c, somatic 0.124977
SCN2A sodium channel, voltage gated, type II alpha subunit 0.124469
CD163 CD163 molecule 0.124405
APC adenomatous polyposis coli 0.124036
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.119261
FLAD1 flavin adenine dinucleotide synthetase 1 0.115119
LOX lysyl oxidase 0.112954
AURKA aurora kinase A 0.112359
GADD45G growth arrest and DNA-damage-inducible, gamma 0.107185
GUSB glucuronidase, beta 0.107122
CTSB cathepsin B 0.106945
IGFBP3 insulin-like growth factor binding protein 3 0.106567
SEBOX SEBOX homeobox 0.105355
GLI2 GLI family zinc finger 2 0.104592
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.104541
YBX1 Y box binding protein 1 0.103182
CTTN cortactin 0.100107
PTHLH parathyroid hormone-like hormone 0.099121
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.098855
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.098643
TOP2A topoisomerase (DNA) II alpha 170kDa 0.098584
GHR growth hormone receptor 0.098274
GPX3 glutathione peroxidase 3 0.097041
GLI1 GLI family zinc finger 1 0.095946
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.094771
HRAS Harvey rat sarcoma viral oncogene homolog 0.093843
DCN decorin 0.09261
PTER phosphotriesterase related 0.091036
GAS7 growth arrest-specific 7 0.089367
KRT20 keratin 20, type I 0.088396
STARD13 StAR-related lipid transfer (START) domain containing 13 0.08802
SATB2 SATB homeobox 2 0.08735
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.087238
PDGFB platelet-derived growth factor beta polypeptide 0.086789
CRYAB crystallin, alpha B 0.086498
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.086159
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.085863
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.085408
KRT7 keratin 7, type II 0.084771
CHD1L chromodomain helicase DNA binding protein 1-like 0.082476
CSF3 colony stimulating factor 3 (granulocyte) 0.081446
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.078546
TTR transthyretin 0.076347
CXCL6 chemokine (C-X-C motif) ligand 6 0.076079
PXN paxillin 0.074517
MB myoglobin 0.072353
TOP1 topoisomerase (DNA) I 0.069772
TAGLN transgelin 0.069299
B3GAT1 beta-1,3-glucuronyltransferase 1 0.069174
F8 coagulation factor VIII, procoagulant component 0.067576
GFAP glial fibrillary acidic protein 0.067076
WT1 Wilms tumor 1 0.0667
PROS1 protein S (alpha) 0.065598
MUC4 mucin 4, cell surface associated 0.06507
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.063313
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.063288