osteosarcoma Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)|A malignant mesenchymal tumor arising from the bone.|A usually aggressive malignant bone-forming mesenchymal tumor, predominantly affecting adolescents and young adults. It usually involves bones and less frequently extraosseous sites. It often involves the long bones (particularly distal femur, proximal tibia, and proximal humerus). Pain with or without a palpable mass is the most frequent clinical symptom. It may spread to other anatomic sites, particularly the lungs. (Experimental Factor Ontology, EFO_0000637)
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Genes

3 genes associated with the disease osteosarcoma in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
EGFR epidermal growth factor receptor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
RB1 retinoblastoma 1