osteosarcoma Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)|A malignant mesenchymal tumor arising from the bone.|A usually aggressive malignant bone-forming mesenchymal tumor, predominantly affecting adolescents and young adults. It usually involves bones and less frequently extraosseous sites. It often involves the long bones (particularly distal femur, proximal tibia, and proximal humerus). Pain with or without a palpable mass is the most frequent clinical symptom. It may spread to other anatomic sites, particularly the lungs. (Experimental Factor Ontology, EFO_0000637)
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Genes

417 genes co-occuring with the biological term osteosarcoma in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAM10 ADAM metallopeptidase domain 10
ADAM8 ADAM metallopeptidase domain 8
ADM adrenomedullin
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALPP alkaline phosphatase, placental
ANXA2 annexin A2
ANXA5 annexin A5
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARHGAP35 Rho GTPase activating protein 35
ASS1 argininosuccinate synthase 1
ATG7 autophagy related 7
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
AURKA aurora kinase A
AXL AXL receptor tyrosine kinase
BAG6 BCL2-associated athanogene 6
BAMBI BMP and activin membrane-bound inhibitor
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL6 B-cell CLL/lymphoma 6
BECN1 beclin 1, autophagy related
BGLAP bone gamma-carboxyglutamate (gla) protein
BID BH3 interacting domain death agonist
BIRC7 baculoviral IAP repeat containing 7
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMP2 bone morphogenetic protein 2
BRD7 bromodomain containing 7
BUB3 BUB3 mitotic checkpoint protein
CADM1 cell adhesion molecule 1
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX3 chromobox homolog 3
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CCNE1 cyclin E1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD24 CD24 molecule
CD276 CD276 molecule
CD34 CD34 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD86 CD86 molecule
CD9 CD9 molecule
CD99 CD99 molecule
CDC5L cell division cycle 5-like
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH5 cadherin 5, type 2 (vascular endothelium)
CDK11B cyclin-dependent kinase 11B
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CENPA centromere protein A
CFLAR CASP8 and FADD-like apoptosis regulator
CGB chorionic gonadotropin, beta polypeptide
CHEK1 checkpoint kinase 1
COL18A1 collagen, type XVIII, alpha 1
COL1A1 collagen, type I, alpha 1
COPS3 COP9 signalosome subunit 3
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CRIP1 cysteine-rich protein 1 (intestinal)
CSK c-src tyrosine kinase
CTGF connective tissue growth factor
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB cathepsin B
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DHFR dihydrofolate reductase
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMP1 dentin matrix acidic phosphoprotein 1
DNASE1L3 deoxyribonuclease I-like 3
DUSP1 dual specificity phosphatase 1
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
ECT2 epithelial cell transforming 2
EDN1 endothelin 1
EFNA1 ephrin-A1
EFNA4 ephrin-A4
EFNB1 ephrin-B1
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF4E eukaryotic translation initiation factor 4E
EPHA2 EPH receptor A2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ERCC2 excision repair cross-complementation group 2
ERCC5 excision repair cross-complementation group 5
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
FAP fibroblast activation protein, alpha
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FASN fatty acid synthase
FBN1 fibrillin 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FDPS farnesyl diphosphate synthase
FGF2 fibroblast growth factor 2 (basic)
FGFR2 fibroblast growth factor receptor 2
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOLR1 folate receptor 1 (adult)
FTL ferritin, light polypeptide
GADD45A growth arrest and DNA-damage-inducible, alpha
GAK cyclin G associated kinase
GAS6 growth arrest-specific 6
GDF2 growth differentiation factor 2
GLI2 GLI family zinc finger 2
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
GSTM1 glutathione S-transferase mu 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
H2AFZ H2A histone family, member Z
HAS2 hyaluronan synthase 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HMGB1 high mobility group box 1
HMGN5 high mobility group nucleosome binding domain 5
HPSE heparanase
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA4 heat shock 70kDa protein 4
ICAM1 intercellular adhesion molecule 1
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFT38 intraflagellar transport 38
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGF2R insulin-like growth factor 2 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL11RA interleukin 11 receptor, alpha
IL12B interleukin 12B
IL1RN interleukin 1 receptor antagonist
IL27 interleukin 27
IL6 interleukin 6
ILK integrin-linked kinase
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ING1 inhibitor of growth family, member 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA6 integrin, alpha 6
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
JUN jun proto-oncogene
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KIAA1524 KIAA1524
KISS1 KiSS-1 metastasis-suppressor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF6 Kruppel-like factor 6
KLF8 Kruppel-like factor 8
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LDHB lactate dehydrogenase B
LEP leptin
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LPAR1 lysophosphatidic acid receptor 1
LPAR3 lysophosphatidic acid receptor 3
LRP5 low density lipoprotein receptor-related protein 5
LSAMP limbic system-associated membrane protein
LUM lumican
LZTS1 leucine zipper, putative tumor suppressor 1
MACC1 metastasis associated in colon cancer 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED19 mediator complex subunit 19
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
MIR100 microRNA 100
MIR126 microRNA 126
MIR132 microRNA 132
MIR133B microRNA 133b
MIR141 microRNA 141
MIR142 microRNA 142
MIR143 microRNA 143
MIR145 microRNA 145
MIR155 microRNA 155
MIR15A microRNA 15a
MIR16-1 microRNA 16-1
MIR17 microRNA 17
MIR17HG miR-17-92 cluster host gene
MIR181A1 microRNA 181a-1
MIR181A2 microRNA 181a-2
MIR183 microRNA 183
MIR199A1 microRNA 199a-1
MIR199A2 microRNA 199a-2
MIR199B microRNA 199b
MIR206 microRNA 206
MIR20A microRNA 20a
MIR21 microRNA 21
MIR210 microRNA 210
MIR214 microRNA 214
MIR218-1 microRNA 218-1
MIR22 microRNA 22
MIR221 microRNA 221
MIR223 microRNA 223
MIR26A1 microRNA 26a-1
MIR29A microRNA 29a
MIR32 microRNA 32
MIR320A microRNA 320a
MIR335 microRNA 335
MIR33A microRNA 33a
MIR340 microRNA 340
MIR34A microRNA 34a
MIR34C microRNA 34c
MIR376C microRNA 376c
MIR451A microRNA 451a
MIR802 microRNA 802
MIR9-1 microRNA 9-1
MIR93 microRNA 93
MKI67 marker of proliferation Ki-67
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MT-ATP6 ATP synthase F0 subunit 6
MT2A metallothionein 2A
MTA1 metastasis associated 1
MTDH metadherin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTNR1A melatonin receptor 1A
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MVP major vault protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NELL1 NEL-like 1 (chicken)
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NF2 neurofibromin 2 (merlin)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
NOTCH1 notch 1
NOV nephroblastoma overexpressed
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR1I2 nuclear receptor subfamily 1, group I, member 2
NRP1 neuropilin 1
OSM oncostatin M
OXT oxytocin/neurophysin I prepropeptide
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDPN podoplanin
PGF placental growth factor
PHB prohibitin
PHC3 polyhomeotic homolog 3 (Drosophila)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIGR polymeric immunoglobulin receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLK1 polo-like kinase 1
PLXDC1 plexin domain containing 1
PON1 paraoxonase 1
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PRDM2 PR domain containing 2, with ZNF domain
PRDX2 peroxiredoxin 2
PRKCA protein kinase C, alpha
PRKCG protein kinase C, gamma
PRKCI protein kinase C, iota
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTCD3 pentatricopeptide repeat domain 3
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH1R parathyroid hormone 1 receptor
PTK2 protein tyrosine kinase 2
PXN paxillin
RAD51 RAD51 recombinase
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
RARA retinoic acid receptor, alpha
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RB1 retinoblastoma 1
RBM14 RNA binding motif protein 14
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RECQL4 RecQ protein-like 4
RECQL5 RecQ protein-like 5
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOA ras homolog family member A
RLN1 relaxin 1
RLN2 relaxin 2
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
ROR2 receptor tyrosine kinase-like orphan receptor 2
RPL7A ribosomal protein L7a
RPS3 ribosomal protein S3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RUNX2 runt-related transcription factor 2
RXRA retinoid X receptor, alpha
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
SASH1 SAM and SH3 domain containing 1
SDC2 syndecan 2
SDC4 syndecan 4
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIRT1 sirtuin 1
SIRT7 sirtuin 7
SIX1 SIX homeobox 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SMO smoothened, frizzled class receptor
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SORBS2 sorbin and SH3 domain containing 2
SOST sclerostin
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SQSTM1 sequestosome 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUMO1 small ubiquitin-like modifier 1
SYK spleen tyrosine kinase
TACR1 tachykinin receptor 1
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TERT telomerase reverse transcriptase
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR1 transforming growth factor, beta receptor 1
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TMSB4X thymosin beta 4, X-linked
TNC tenascin C
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOP1 topoisomerase (DNA) I
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TPP1 tripeptidyl peptidase I
TRABD2B TraB domain containing 2B
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM22 tripartite motif containing 22
TRPS1 trichorhinophalangeal syndrome I
TUG1 taurine up-regulated 1 (non-protein coding)
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
TWIST1 twist family bHLH transcription factor 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
URGCP upregulator of cell proliferation
USP1 ubiquitin specific peptidase 1
VASP vasodilator-stimulated phosphoprotein
VCP valosin containing protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WIF1 WNT inhibitory factor 1
WISP1 WNT1 inducible signaling pathway protein 1
WNT10B wingless-type MMTV integration site family, member 10B
WNT5A wingless-type MMTV integration site family, member 5A
WRN Werner syndrome, RecQ helicase-like
WWOX WW domain containing oxidoreductase
XPO1 exportin 1
YAP1 Yes-associated protein 1
YY1 YY1 transcription factor
ZEB1 zinc finger E-box binding homeobox 1
ZNF395 zinc finger protein 395