osteosclerosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A bone remodeling disease that results_in abnormal elevated bone density or mass. (Human Disease Ontology, DOID_4254)
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Genes

247 genes co-occuring with the disease osteosclerosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CLCN7 chloride channel, voltage-sensitive 7 2.60801
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 2.49006
OSTM1 osteopetrosis associated transmembrane protein 1 2.2298
CA2 carbonic anhydrase II 1.97877
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 1.8987
LEMD3 LEM domain containing 3 1.835
CTSK cathepsin K 1.82368
MIR4315-2 microRNA 4315-2 1.72821
MIR4315-1 microRNA 4315-1 1.72821
ANKH ANKH inorganic pyrophosphate transport regulator 1.63232
CSF1 colony stimulating factor 1 (macrophage) 1.62784
SNX10 sorting nexin 10 1.56889
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.52512
ADO 2-aminoethanethiol (cysteamine) dioxygenase 1.48384
ALPL alkaline phosphatase, liver/bone/kidney 1.47638
ALPPL2 alkaline phosphatase, placental-like 2 1.46583
ALPP alkaline phosphatase, placental 1.46539
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.45924
ACPP acid phosphatase, prostate 1.43639
PTH parathyroid hormone 1.33981
BGLAP bone gamma-carboxyglutamate (gla) protein 1.32367
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 1.2656
DNAH8 dynein, axonemal, heavy chain 8 1.25733
FAM20C family with sequence similarity 20, member C 1.25254
LRP5 low density lipoprotein receptor-related protein 5 1.23994
TYROBP TYRO protein tyrosine kinase binding protein 1.191
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.14942
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.149
SLC4A2 solute carrier family 4 (anion exchanger), member 2 1.13289
CCDC154 coiled-coil domain containing 154 1.12151
MITF microphthalmia-associated transcription factor 1.10931
TGFB1 transforming growth factor, beta 1 1.09335
SOST sclerostin 1.08957
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.08202
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 1.06606
DCSTAMP dendrocyte expressed seven transmembrane protein 1.05723
SIGLEC15 sialic acid binding Ig-like lectin 15 1.05723
CSF1R colony stimulating factor 1 receptor 1.02735
FOSL1 FOS-like antigen 1 1.02187
SP7 Sp7 transcription factor 1.01216
CALCA calcitonin-related polypeptide alpha 0.999924
FERMT3 fermitin family member 3 0.994861
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.975903
ALYREF Aly/REF export factor 0.957033
CLCN3 chloride channel, voltage-sensitive 3 0.936214
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 0.914315
FOS FBJ murine osteosarcoma viral oncogene homolog 0.904854
MSX2 msh homeobox 2 0.853221
TMEM165 transmembrane protein 165 0.851173
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 0.844621
THPO thrombopoietin 0.840934
RGS10 regulator of G-protein signaling 10 0.822077
OSCAR osteoclast associated, immunoglobulin-like receptor 0.796642
RUNX2 runt-related transcription factor 2 0.783936
BMP2 bone morphogenetic protein 2 0.777386
CSK c-src tyrosine kinase 0.774523
GBP4 guanylate binding protein 4 0.772887
AMER1 APC membrane recruitment protein 1 0.771661
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.771661
CD68 CD68 molecule 0.728952
TFEC transcription factor EC 0.72612
FAM3C family with sequence similarity 3, member C 0.722482
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.708767
ACP5 acid phosphatase 5, tartrate resistant 0.700321
FERMT2 fermitin family member 2 0.682294
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.674315
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.635921
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 0.633563
PTHLH parathyroid hormone-like hormone 0.59952
SEBOX SEBOX homeobox 0.597961
LTBP3 latent transforming growth factor beta binding protein 3 0.592895
RPL12 ribosomal protein L12 0.568775
IHH indian hedgehog 0.5645
LTBP2 latent transforming growth factor beta binding protein 2 0.55518
TSPAN16 tetraspanin 16 0.543542
FERMT1 fermitin family member 1 0.541605
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 0.536183
PLEK pleckstrin 0.534635
NFIA nuclear factor I/A 0.533088
DEFB105B defensin, beta 105B 0.530768
PKLR pyruvate kinase, liver and RBC 0.510344
RPS19BP1 ribosomal protein S19 binding protein 1 0.500761
COL1A2 collagen, type I, alpha 2 0.483604
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.483224
NOG noggin 0.483224
EXTL2 exostosin-like glycosyltransferase 2 0.482844
AACS acetoacetyl-CoA synthetase 0.468819
S1PR2 sphingosine-1-phosphate receptor 2 0.467684
BMP4 bone morphogenetic protein 4 0.46466
SPP1 secreted phosphoprotein 1 0.461261
MSX1 msh homeobox 1 0.454847
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 0.45447
SPI1 Spi-1 proto-oncogene 0.452585
LRRK1 leucine-rich repeat kinase 1 0.448817
COL1A1 collagen, type I, alpha 1 0.446558
GC group-specific component (vitamin D binding protein) 0.445429
PKM pyruvate kinase, muscle 0.4443
TRAPPC10 trafficking protein particle complex 10 0.441666
TGFBR1 transforming growth factor, beta receptor 1 0.439786
S1PR1 sphingosine-1-phosphate receptor 1 0.437906
BMP7 bone morphogenetic protein 7 0.435651
FGF23 fibroblast growth factor 23 0.434524
BSND barttin CLCNK-type chloride channel accessory beta subunit 0.433021
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.42139
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.420641
CA4 carbonic anhydrase IV 0.415398
KIAA0226 KIAA0226 0.413901
FYN FYN proto-oncogene, Src family tyrosine kinase 0.412031
GPNMB glycoprotein (transmembrane) nmb 0.410535
BBX bobby sox homolog (Drosophila) 0.399707
SLC4A3 solute carrier family 4 (anion exchanger), member 3 0.397843
PHEX phosphate regulating endopeptidase homolog, X-linked 0.389653
JDP2 Jun dimerization protein 2 0.389281
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.387423
TFEB transcription factor EB 0.383708
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.37555
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.368149
ITGB5 integrin, beta 5 0.351555
GAB2 GRB2-associated binding protein 2 0.344941
HRAS Harvey rat sarcoma viral oncogene homolog 0.344574
JAK2 Janus kinase 2 0.335778
EDARADD EDAR-associated death domain 0.333218
MRO maestro 0.332487
HMGA2 high mobility group AT-hook 2 0.327375
NFIB nuclear factor I/B 0.320817
FEN1 flap structure-specific endonuclease 1 0.318635
BMP10 bone morphogenetic protein 10 0.317909
ARSD arylsulfatase D 0.315366
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.311739
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.311377
TNF tumor necrosis factor 0.307757
TGM5 transglutaminase 5 0.307757
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.305226
DMP1 dentin matrix acidic phosphoprotein 1 0.304142
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 0.294413
KL klotho 0.287593
UVRAG UV radiation resistance associated 0.283297
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1 0.28151
STX16 syntaxin 16 0.279724
CD34 CD34 molecule 0.276158
CTSS cathepsin S 0.275801
KNTC1 kinetochore associated 1 0.272953
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 0.271886
AMELY amelogenin, Y-linked 0.266558
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 0.263368
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.263014
LIM2 lens intrinsic membrane protein 2, 19kDa 0.261245
BMP6 bone morphogenetic protein 6 0.257358
IL1A interleukin 1, alpha 0.257005
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 0.254183
CALCR calcitonin receptor 0.249257
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.248554
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 0.241895
TLN1 talin 1 0.241546
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.238403
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 0.238054
AMELX amelogenin, X-linked 0.237357
BMP8B bone morphogenetic protein 8b 0.234225
IBSP integrin-binding sialoprotein 0.23353
BMPR1B bone morphogenetic protein receptor, type IB 0.233183
MEOX2 mesenchyme homeobox 2 0.228333
DLL3 delta-like 3 (Drosophila) 0.222822
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.221108
AMBN ameloblastin (enamel matrix protein) 0.21974
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.218715
JUN jun proto-oncogene 0.212608
CRTAP cartilage associated protein 0.211261
BMP3 bone morphogenetic protein 3 0.208245
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 0.206913
EXT1 exostosin glycosyltransferase 1 0.205585
TREM2 triggering receptor expressed on myeloid cells 2 0.205585
PPA1 pyrophosphatase (inorganic) 1 0.204923
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.203604
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.202946
P3H1 prolyl 3-hydroxylase 1 0.201962
OSM oncostatin M 0.200006
GATA2 GATA binding protein 2 0.199356
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.198386
ACP2 acid phosphatase 2, lysosomal 0.198064
TFE3 transcription factor binding to IGHM enhancer 3 0.194232
SPHK1 sphingosine kinase 1 0.189859
PCSK2 proprotein convertase subtilisin/kexin type 2 0.185612
PCP2 Purkinje cell protein 2 0.182666
CLCN6 chloride channel, voltage-sensitive 6 0.179802
WRAP73 WD repeat containing, antisense to TP73 0.17952
SLC26A6 solute carrier family 26 (anion exchanger), member 6 0.177576
BLNK B-cell linker 0.174354
WNT3A wingless-type MMTV integration site family, member 3A 0.172291
ERCC2 excision repair cross-complementation group 2 0.169812
ARF1 ADP-ribosylation factor 1 0.16933
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.168148
VAV3 vav 3 guanine nucleotide exchange factor 0.167682
CLIC1 chloride intracellular channel 1 0.166544
SQSTM1 sequestosome 1 0.164786
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.164786
TMEM51 transmembrane protein 51 0.164571
ADAM28 ADAM metallopeptidase domain 28 0.161716
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 0.160387
GMPS guanine monphosphate synthase 0.160021
ELN elastin 0.158434
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 0.158266
ACVR1 activin A receptor, type I 0.144855
BMP1 bone morphogenetic protein 1 0.143865
LOXL2 lysyl oxidase-like 2 0.143383
SMAD3 SMAD family member 3 0.142984
HDAC4 histone deacetylase 4 0.14243
SMAD2 SMAD family member 2 0.141905
FGFR3 fibroblast growth factor receptor 3 0.140116
LRP6 low density lipoprotein receptor-related protein 6 0.138994
WNT1 wingless-type MMTV integration site family, member 1 0.1379
POSTN periostin, osteoblast specific factor 0.137863
IRAK3 interleukin-1 receptor-associated kinase 3 0.13772
HTN3 histatin 3 0.136735
FLNA filamin A, alpha 0.136261
GNAS GNAS complex locus 0.136203
COL10A1 collagen, type X, alpha 1 0.135144
IRAK4 interleukin-1 receptor-associated kinase 4 0.132997
ADCY2 adenylate cyclase 2 (brain) 0.132519
IL12RB1 interleukin 12 receptor, beta 1 0.131497
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.130029
KITLG KIT ligand 0.126314
LDLR low density lipoprotein receptor 0.1256
GHR growth hormone receptor 0.12272
KLF4 Kruppel-like factor 4 (gut) 0.121829
SMAD7 SMAD family member 7 0.118066
SOX2 SRY (sex determining region Y)-box 2 0.114077
IGF2 insulin-like growth factor 2 0.110507
GJA1 gap junction protein, alpha 1, 43kDa 0.108604
MMP13 matrix metallopeptidase 13 0.107405
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.104201
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.104037
ANO5 anoctamin 5 0.103955
SH3BP2 SH3-domain binding protein 2 0.103459
MYD88 myeloid differentiation primary response 88 0.103332
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.102744
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.102618
CA14 carbonic anhydrase XIV 0.10163
HLA-A major histocompatibility complex, class I, A 0.100668
SMAD4 SMAD family member 4 0.100095
FGF2 fibroblast growth factor 2 (basic) 0.099735
PREB prolactin regulatory element binding 0.09969
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.097958
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 0.097774
NF1 neurofibromin 1 0.097168
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.09665
SYP synaptophysin 0.096603
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.095746