otitis media Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A otitis which involves inflammation of the middle ear. (Human Disease Ontology, DOID_10754)
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Genes

302 genes co-occuring with the disease otitis media in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HTRA3 HtrA serine peptidase 3 1.84545
PDZD11 PDZ domain containing 11 1.72319
CD79A CD79a molecule, immunoglobulin-associated alpha 1.66015
PLS1 plastin 1 1.50272
MUC5B mucin 5B, oligomeric mucus/gel-forming 1.49745
FBXO11 F-box protein 11 1.37905
IL1B interleukin 1, beta 1.28523
TLR2 toll-like receptor 2 1.2495
A1BG alpha-1-B glycoprotein 1.24515
TNF tumor necrosis factor 1.18712
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 1.14093
COPB1 coatomer protein complex, subunit beta 1 1.12656
CKAP2 cytoskeleton associated protein 2 1.12445
TLR4 toll-like receptor 4 1.11225
MUC19 mucin 19, oligomeric 1.1051
GK2 glycerol kinase 2 1.08663
DEFB123 defensin, beta 123 1.08663
LYZ lysozyme 1.07572
PRTN3 proteinase 3 1.0484
LTF lactotransferrin 1.04083
PATE1 prostate and testis expressed 1 1.00794
KSR1 kinase suppressor of ras 1 0.989379
CXCL8 chemokine (C-X-C motif) ligand 8 0.984743
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 0.961216
N6AMT2 N-6 adenine-specific DNA methyltransferase 2 (putative) 0.95996
ALB albumin 0.957868
HSF4 heat shock transcription factor 4 0.953273
CD4 CD4 molecule 0.920085
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 0.910199
PPBPP1 pro-platelet basic protein pseudogene 1 0.906909
MAP2K3 mitogen-activated protein kinase kinase 3 0.90321
MUC2 mucin 2, oligomeric mucus/gel-forming 0.888438
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase 0.885569
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.880243
MUC12 mucin 12, cell surface associated 0.871643
CAPN14 calpain 14 0.867959
CD19 CD19 molecule 0.864274
EYA4 EYA transcriptional coactivator and phosphatase 4 0.863865
TICRR TOPBP1-interacting checkpoint and replication regulator 0.845031
CFP complement factor properdin 0.844211
DEFB103B defensin, beta 103B 0.839296
C1R complement component 1, r subcomponent 0.838476
TTLL1 tubulin tyrosine ligase-like family member 1 0.838476
MUC20 mucin 20, cell surface associated 0.822897
C1S complement component 1, s subcomponent 0.821257
PGM2 phosphoglucomutase 2 0.815924
DEFB1 defensin, beta 1 0.80936
SMCP sperm mitochondria-associated cysteine-rich protein 0.806898
MUC4 mucin 4, cell surface associated 0.803205
MUC15 mucin 15, cell surface associated 0.798692
CA4 carbonic anhydrase IV 0.787213
RPL38 ribosomal protein L38 0.771661
MPO myeloperoxidase 0.759008
TUBE1 tubulin, epsilon 1 0.748017
IL1A interleukin 1, alpha 0.739082
CRP C-reactive protein, pentraxin-related 0.736649
HAX1 HCLS1 associated protein X-1 0.725716
C1QA complement component 1, q subcomponent, A chain 0.711989
CLEC3A C-type lectin domain family 3, member A 0.703938
CLEC2B C-type lectin domain family 2, member B 0.698715
NR2F6 nuclear receptor subfamily 2, group F, member 6 0.69751
MBL2 mannose-binding lectin (protein C) 2, soluble 0.695905
GJB2 gap junction protein, beta 2, 26kDa 0.695905
DNAH11 dynein, axonemal, heavy chain 11 0.695103
CLEC10A C-type lectin domain family 10, member A 0.673917
RNASE3 ribonuclease, RNase A family, 3 0.66914
MYD88 myeloid differentiation primary response 88 0.667947
MUC13 mucin 13, cell surface associated 0.66596
PER1 period circadian clock 1 0.659215
DEFB4A defensin, beta 4A 0.656441
DNAH1 dynein, axonemal, heavy chain 1 0.654858
SPPL2C signal peptide peptidase like 2C 0.653671
IL6 interleukin 6 0.646559
SOD2 superoxide dismutase 2, mitochondrial 0.643797
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 0.633956
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.633956
MAPK14 mitogen-activated protein kinase 14 0.624143
IDS iduronate 2-sulfatase 0.622967
CDCA7 cell division cycle associated 7 0.622183
CAT catalase 0.617486
PGRMC1 progesterone receptor membrane component 1 0.612401
SRRM2 serine/arginine repetitive matrix 2 0.612011
LIPT1 lipoyltransferase 1 0.610057
BRI3 brain protein I3 0.60303
KANSL1 KAT8 regulatory NSL complex subunit 1 0.594843
BTK Bruton agammaglobulinemia tyrosine kinase 0.594454
ACPP acid phosphatase, prostate 0.581217
CCDC40 coiled-coil domain containing 40 0.577716
BMP8A bone morphogenetic protein 8a 0.574605
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.562946
SHOX short stature homeobox 0.555568
C3 complement component 3 0.55518
TAC1 tachykinin, precursor 1 0.553627
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.552463
CTSB cathepsin B 0.537344
CD69 CD69 molecule 0.533475
CCDC39 coiled-coil domain containing 39 0.529608
ICAM1 intercellular adhesion molecule 1 0.529608
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.528063
MARK3 MAP/microtubule affinity-regulating kinase 3 0.520346
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 0.51842
SPEF2 sperm flagellar 2 0.517649
A4GALT alpha 1,4-galactosyltransferase 0.516879
TLR5 toll-like receptor 5 0.51534
EARS2 glutamyl-tRNA synthetase 2, mitochondrial 0.51534
TLR9 toll-like receptor 9 0.514186
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 0.50689
MUC1 mucin 1, cell surface associated 0.506123
TCERG1L transcription elongation regulator 1-like 0.503824
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 0.495411
SELL selectin L 0.49274
ERAS ES cell expressed Ras 0.487027
HAS1 hyaluronan synthase 1 0.482464
MUC7 mucin 7, secreted 0.478289
CD248 CD248 molecule, endosialin 0.471089
NOTCH1 notch 1 0.461639
AK7 adenylate kinase 7 0.456355
FETUB fetuin B 0.440914
AMBP alpha-1-microglobulin/bikunin precursor 0.440914
NCOA1 nuclear receptor coactivator 1 0.440162
DEFB103A defensin, beta 103A 0.438282
TGIF1 TGFB-induced factor homeobox 1 0.433772
FGF7 fibroblast growth factor 7 0.430393
SPAG6 sperm associated antigen 6 0.429642
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.42589
LY75 lymphocyte antigen 75 0.424014
MCPH1 microcephalin 1 0.424014
NANS N-acetylneuraminic acid synthase 0.421016
TTL tubulin tyrosine ligase 0.420266
CA13 carbonic anhydrase XIII 0.417644
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64) 0.412405
MUC17 mucin 17, cell surface associated 0.410161
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.409787
CYLD cylindromatosis (turban tumor syndrome) 0.409414
SPAG11B sperm associated antigen 11B 0.404184
EHF ets homologous factor 0.396725
SH3PXD2B SH3 and PX domains 2B 0.394491
KIF7 kinesin family member 7 0.392629
FGF3 fibroblast growth factor 3 0.380368
SRPX2 sushi-repeat containing protein, X-linked 2 0.379626
TLR1 toll-like receptor 1 0.371847
PRAMEF10 PRAME family member 10 0.369628
GPX5 glutathione peroxidase 5 0.362239
BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino 0.359289
SUMF2 sulfatase modifying factor 2 0.359289
GPX4 glutathione peroxidase 4 0.35892
MUC16 mucin 16, cell surface associated 0.355235
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.354131
PDLIM1 PDZ and LIM domain 1 0.354131
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.347879
CFHR1 complement factor H-related 1 0.347511
GPX1 glutathione peroxidase 1 0.344207
C5AR1 complement component 5a receptor 1 0.343106
DOCK1 dedicator of cytokinesis 1 0.337975
DARS2 aspartyl-tRNA synthetase 2, mitochondrial 0.337608
PRAMEF12 PRAME family member 12 0.335778
UNC119 unc-119 homolog (C. elegans) 0.333949
CD68 CD68 molecule 0.332852
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.332121
PER2 period circadian clock 2 0.330295
SBDS Shwachman-Bodian-Diamond syndrome 0.325552
PTGDR2 prostaglandin D2 receptor 2 0.323365
C11ORF40 chromosome 11 open reading frame 40 0.322637
TREM1 triggering receptor expressed on myeloid cells 1 0.319363
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.315366
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.31029
CD84 CD84 molecule 0.308118
BMP10 bone morphogenetic protein 10 0.307033
TF transferrin 0.305587
FLNA filamin A, alpha 0.305587
ARSD arylsulfatase D 0.304864
MARK2 MAP/microtubule affinity-regulating kinase 2 0.304864
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.300894
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) 0.300533
TSPO translocator protein (18kDa) 0.299092
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 0.297651
ENSA endosulfine alpha 0.294772
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 0.292975
FGF10 fibroblast growth factor 10 0.292257
AQP5 aquaporin 5 0.291539
TYMP thymidine phosphorylase 0.291539
BET1 Bet1 golgi vesicular membrane trafficking protein 0.289744
BPI bactericidal/permeability-increasing protein 0.289386
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.289027
KRTAP1-3 keratin associated protein 1-3 0.289027
KRTAP1-1 keratin associated protein 1-1 0.289027
MTO1 mitochondrial tRNA translation optimization 1 0.28294
SRM spermidine synthase 0.28294
PRF1 perforin 1 (pore forming protein) 0.281868
LAP3 leucine aminopeptidase 3 0.28151
ELANE elastase, neutrophil expressed 0.28151
C4A complement component 4A (Rodgers blood group) 0.278297
CD22 CD22 molecule 0.27794
SECISBP2 SECIS binding protein 2 0.275801
BTC betacellulin 0.274732
PLG plasminogen 0.274376
FGF6 fibroblast growth factor 6 0.272241
GPR162 G protein-coupled receptor 162 0.271886
NARS asparaginyl-tRNA synthetase 0.27153
MGP matrix Gla protein 0.269753
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.26514
TBX1 T-box 1 0.264785
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.264785
IGLV9-49 immunoglobulin lambda variable 9-49 0.264785
NT5C 5', 3'-nucleotidase, cytosolic 0.264431
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 0.263722
BIN2 bridging integrator 2 0.263722
PCNA proliferating cell nuclear antigen 0.263368
CD40LG CD40 ligand 0.258417
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.256652
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.256299
NOD1 nucleotide-binding oligomerization domain containing 1 0.253127
JUN jun proto-oncogene 0.249608
GALP galanin-like peptide 0.245046
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 0.238403
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.237009
FAIM2 Fas apoptotic inhibitory molecule 2 0.234573
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.232836
BMP6 bone morphogenetic protein 6 0.231102
SMAD2 SMAD family member 2 0.230409
PGM1 phosphoglucomutase 1 0.229716
CD28 CD28 molecule 0.224884
BCL10 B-cell CLL/lymphoma 10 0.22454
BMP8B bone morphogenetic protein 8b 0.223853
KMT2A lysine (K)-specific methyltransferase 2A 0.223853
ACACB acetyl-CoA carboxylase beta 0.222479
MAP3K12 mitogen-activated protein kinase kinase kinase 12 0.222479
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 0.220766
KNG1 kininogen 1 0.21974
DHRS9 dehydrogenase/reductase (SDR family) member 9 0.218374
FZD6 frizzled class receptor 6 0.218034
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 0.217693
ADSL adenylosuccinate lyase 0.213621
TPPP tubulin polymerization promoting protein 0.211597
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.211597
DDIT3 DNA-damage-inducible transcript 3 0.211597
C4B complement component 4B (Chido blood group) 0.210589
CCL23 chemokine (C-C motif) ligand 23 0.209248
HP haptoglobin 0.208245
DNAI1 dynein, axonemal, intermediate chain 1 0.206913
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.205254
HPR haptoglobin-related protein 0.202946
IL10 interleukin 10 0.202618
CA10 carbonic anhydrase X 0.202618
BCL6 B-cell CLL/lymphoma 6 0.202618
MAPK11 mitogen-activated protein kinase 11 0.20229
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.201308
SFTPA2 surfactant protein A2 0.200982
DPP7 dipeptidyl-peptidase 7 0.200656
PERP PERP, TP53 apoptosis effector 0.200331
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.199033
BMP3 bone morphogenetic protein 3 0.198709
NT5C1A 5'-nucleotidase, cytosolic IA 0.192031
BMP5 bone morphogenetic protein 5 0.191719
ATOH1 atonal homolog 1 (Drosophila) 0.191408
AMER1 APC membrane recruitment protein 1 0.188938
DNASE1 deoxyribonuclease I 0.187719
HPX hemopexin 0.187113
GDF2 growth differentiation factor 2 0.18651
ESPN espin 0.183248
BID BH3 interacting domain death agonist 0.182666
DPEP1 dipeptidase 1 (renal) 0.181222
EPHA4 EPH receptor A4 0.17952
CFB complement factor B 0.176485
PGM3 phosphoglucomutase 3 0.174881
PCP2 Purkinje cell protein 2 0.174354
FGF5 fibroblast growth factor 5 0.174354
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.173314
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.172038
PER3 period circadian clock 3 0.167224
NTM neurotrimin 0.165874
ALOX5 arachidonate 5-lipoxygenase 0.165655
TGFB1 transforming growth factor, beta 1 0.164786
CD59 CD59 molecule, complement regulatory protein 0.163729
PTPRC protein tyrosine phosphatase, receptor type, C 0.163317
MDH1 malate dehydrogenase 1, NAD (soluble) 0.163111
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.162908
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.162306
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 0.161139
CTSS cathepsin S 0.160574
CFAP74 cilia and flagella associated protein 74 0.160574
BCAM basal cell adhesion molecule (Lutheran blood group) 0.158778
SPDEF SAM pointed domain containing ETS transcription factor 0.158778
HM13 histocompatibility (minor) 13 0.143083
COCH cochlin 0.143069
CTNS cystinosin, lysosomal cystine transporter 0.142402
OR10K1 olfactory receptor, family 10, subfamily K, member 1 0.142091
NBPF10 neuroblastoma breakpoint family, member 10 0.140987
LARS leucyl-tRNA synthetase 0.13881
IL7 interleukin 7 0.138688
OR4F29 olfactory receptor, family 4, subfamily F, member 29 0.13851
MUT methylmalonyl CoA mutase 0.138446
IL7R interleukin 7 receptor 0.136708
CD163 CD163 molecule 0.135661
HMGA2 high mobility group AT-hook 2 0.13435
BMP2 bone morphogenetic protein 2 0.132394
MLANA melan-A 0.13225
FOXN1 forkhead box N1 0.131637
HSH2D hematopoietic SH2 domain containing 0.130882
DAND5 DAN domain family member 5, BMP antagonist 0.126764
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0962
TFRC transferrin receptor 0.093261