otub1 Gene Set

Dataset	GeneRIF Biological Term Annotations
Category	structural or functional annotations
Type	biological term
Description	OTU deubiquitinase, ubiquitin aldehyde binding 1\|The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 55611)
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Genes

13 genes co-occuring with the biological term otub1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol	Name
BIRC2	baculoviral IAP repeat containing 2
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
ESR1	estrogen receptor 1
NMRAL1	NmrA-like family domain containing 1
OTUB1	OTU deubiquitinase, ubiquitin aldehyde binding 1
OTUB2	OTU deubiquitinase, ubiquitin aldehyde binding 2
TGFB1	transforming growth factor, beta 1
TP53	tumor protein p53
TRAF3	TNF receptor-associated factor 3
TRAF6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UBE2D3	ubiquitin-conjugating enzyme E2D 3
UBE2N	ubiquitin-conjugating enzyme E2N
UBE2V2	ubiquitin-conjugating enzyme E2 variant 2