ouabain-5026 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ouabain-5026 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADM adrenomedullin
AMOTL2 angiomotin like 2
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
ATF7IP activating transcription factor 7 interacting protein
AVPI1 arginine vasopressin-induced 1
BCL6 B-cell CLL/lymphoma 6
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CCNL1 cyclin L1
CCNT2 cyclin T2
CLDN1 claudin 1
CLK1 CDC-like kinase 1
CLK4 CDC-like kinase 4
CTGF connective tissue growth factor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCP1A decapping mRNA 1A
DDIT3 DNA-damage-inducible transcript 3
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP8 dual specificity phosphatase 8
EDN1 endothelin 1
EED embryonic ectoderm development
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EPHA2 EPH receptor A2
EWSR1 EWS RNA-binding protein 1
FLCN folliculin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FOXJ3 forkhead box J3
GEM GTP binding protein overexpressed in skeletal muscle
HBP1 HMG-box transcription factor 1
HCFC2 host cell factor C2
HIC2 hypermethylated in cancer 2
HIST1H1E histone cluster 1, H1e
HIST1H1T histone cluster 1, H1t
HIST1H3E histone cluster 1, H3e
HIST1H4C histone cluster 1, H4c
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXC13 homeobox C13
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL6 interleukin 6
ING1 inhibitor of growth family, member 1
IP6K2 inositol hexakisphosphate kinase 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM6A lysine (K)-specific demethylase 6A
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLHL20 kelch-like family member 20
KLHL24 kelch-like family member 24
LINS lines homolog (Drosophila)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MCL1 myeloid cell leukemia 1
MTRF1L mitochondrial translational release factor 1-like
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OVOL1 ovo-like zinc finger 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RARG retinoic acid receptor, gamma
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
SERTAD3 SERTA domain containing 3
SFPQ splicing factor proline/glutamine-rich
SKIL SKI-like proto-oncogene
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SPRY4 sprouty homolog 4 (Drosophila)
SRSF5 serine/arginine-rich splicing factor 5
STX3 syntaxin 3
THAP1 THAP domain containing, apoptosis associated protein 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRA2A transformer 2 alpha homolog (Drosophila)
TXNIP thioredoxin interacting protein
UBE2H ubiquitin-conjugating enzyme E2H
WEE1 WEE1 G2 checkpoint kinase
YTHDC1 YTH domain containing 1
ZBTB17 zinc finger and BTB domain containing 17
ZBTB40 zinc finger and BTB domain containing 40
ZBTB43 zinc finger and BTB domain containing 43
ZEB1 zinc finger E-box binding homeobox 1
ZFP36 ZFP36 ring finger protein
ZMYM5 zinc finger, MYM-type 5
ZNF335 zinc finger protein 335
ZNF654 zinc finger protein 654
ZNF750 zinc finger protein 750

decreased expression

Symbol Name
ADAT1 adenosine deaminase, tRNA-specific 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD46 ankyrin repeat domain 46
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARMCX1 armadillo repeat containing, X-linked 1
ASB13 ankyrin repeat and SOCS box containing 13
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BBX bobby sox homolog (Drosophila)
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
CANT1 calcium activated nucleotidase 1
CBR3 carbonyl reductase 3
CBR4 carbonyl reductase 4
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CSK c-src tyrosine kinase
DET1 de-etiolated homolog 1 (Arabidopsis)
DNAAF2 dynein, axonemal, assembly factor 2
ECHDC3 enoyl CoA hydratase domain containing 3
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
EMC2 ER membrane protein complex subunit 2
ERCC6L excision repair cross-complementation group 6-like
FADD Fas (TNFRSF6)-associated via death domain
FAM86B1 family with sequence similarity 86, member B1
FAN1 FANCD2/FANCI-associated nuclease 1
FANCF Fanconi anemia, complementation group F
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GEMIN4 gem (nuclear organelle) associated protein 4
GEMIN6 gem (nuclear organelle) associated protein 6
GOLGA5 golgin A5
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
H2AFY2 H2A histone family, member Y2
HIRIP3 HIRA interacting protein 3
HPS6 Hermansky-Pudlak syndrome 6
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IPP intracisternal A particle-promoted polypeptide
KRCC1 lysine-rich coiled-coil 1
LINC00339 long intergenic non-protein coding RNA 339
MCM3AP-AS1 MCM3AP antisense RNA 1
MEIS1 Meis homeobox 1
METTL13 methyltransferase like 13
MKKS McKusick-Kaufman syndrome
MKS1 Meckel syndrome, type 1
MPPED2 metallophosphoesterase domain containing 2
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NLK nemo-like kinase
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OCEL1 occludin/ELL domain containing 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAAF1 proteasomal ATPase-associated factor 1
PAGR1 PAXIP1 associated glutamate-rich protein 1
PALB2 partner and localizer of BRCA2
PCF11 PCF11 cleavage and polyadenylation factor subunit
PDZRN3 PDZ domain containing ring finger 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POGK pogo transposable element with KRAB domain
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PTK6 protein tyrosine kinase 6
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RHOBTB1 Rho-related BTB domain containing 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPP40 ribonuclease P/MRP 40kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSAD1 radical S-adenosyl methionine domain containing 1
S100PBP S100P binding protein
SACS sacsin molecular chaperone
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SPATA7 spermatogenesis associated 7
STARD7 StAR-related lipid transfer (START) domain containing 7
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TBC1D31 TBC1 domain family, member 31
TFB1M transcription factor B1, mitochondrial
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRAPPC11 trafficking protein particle complex 11
TRIM16 tripartite motif containing 16
TRIM27 tripartite motif containing 27
TRIM45 tripartite motif containing 45
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TRMT61B tRNA methyltransferase 61B
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TXNRD3 thioredoxin reductase 3
WDR3 WD repeat domain 3
XBP1 X-box binding protein 1
XPA xeroderma pigmentosum, complementation group A
ZBED1 zinc finger, BED-type containing 1
ZBED8 zinc finger, BED-type containing 8
ZBTB24 zinc finger and BTB domain containing 24
ZBTB3 zinc finger and BTB domain containing 3
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC2 zinc finger, CCHC domain containing 2
ZIC1 Zic family member 1
ZNF23 zinc finger protein 23
ZNF239 zinc finger protein 239
ZNF248 zinc finger protein 248
ZNF623 zinc finger protein 623
ZXDC ZXD family zinc finger C