ouabain-6680 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the ouabain-6680 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADM adrenomedullin
AMOTL2 angiomotin like 2
ARC activity-regulated cytoskeleton-associated protein
AREG amphiregulin
ARL14 ADP-ribosylation factor-like 14
ATAD2B ATPase family, AAA domain containing 2B
ATF3 activating transcription factor 3
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BDNF brain-derived neurotrophic factor
BIRC3 baculoviral IAP repeat containing 3
BLZF1 basic leucine zipper nuclear factor 1
C17ORF53 chromosome 17 open reading frame 53
C3ORF52 chromosome 3 open reading frame 52
CCNL1 cyclin L1
CD83 CD83 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLCF1 cardiotrophin-like cytokine factor 1
CLCN6 chloride channel, voltage-sensitive 6
CLK1 CDC-like kinase 1
CREB5 cAMP responsive element binding protein 5
CRY2 cryptochrome circadian clock 2
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH3 cytohesin 3
DBF4B DBF4 zinc finger B
DDIT3 DNA-damage-inducible transcript 3
DLC1 DLC1 Rho GTPase activating protein
DLX2 distal-less homeobox 2
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EED embryonic ectoderm development
EFNA1 ephrin-A1
EGR1 early growth response 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM46C family with sequence similarity 46, member C
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GPR87 G protein-coupled receptor 87
HIC2 hypermethylated in cancer 2
HIST1H1E histone cluster 1, H1e
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HIST1H4D histone cluster 1, H4d
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IL33R interleukin 33 receptor
IL6 interleukin 6
IP6K2 inositol hexakisphosphate kinase 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF6 Kruppel-like factor 6
KLHL20 kelch-like family member 20
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LINC00597 long intergenic non-protein coding RNA 597
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MYLIP myosin regulatory light chain interacting protein
MYOZ3 myozenin 3
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRDM1 PR domain containing 1, with ZNF domain
PSPC1 paraspeckle component 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RHOB ras homolog family member B
RND1 Rho family GTPase 1
RSRC2 arginine/serine-rich coiled-coil 2
SFPQ splicing factor proline/glutamine-rich
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SMAD7 SMAD family member 7
SRSF5 serine/arginine-rich splicing factor 5
STK17B serine/threonine kinase 17b
TEX14 testis expressed 14
TGFB2 transforming growth factor, beta 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOB2 transducer of ERBB2, 2
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
YTHDC1 YTH domain containing 1
ZBTB10 zinc finger and BTB domain containing 10
ZBTB43 zinc finger and BTB domain containing 43
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALPK1 alpha-kinase 1
ANKRD36B ankyrin repeat domain 36B
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APOL6 apolipoprotein L, 6
ASB13 ankyrin repeat and SOCS box containing 13
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BEND5 BEN domain containing 5
C11ORF63 chromosome 11 open reading frame 63
C16ORF59 chromosome 16 open reading frame 59
C2ORF68 chromosome 2 open reading frame 68
C3 complement component 3
CBR3 carbonyl reductase 3
CBX8 chromobox homolog 8
CCDC85C coiled-coil domain containing 85C
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CNIH3 cornichon family AMPA receptor auxiliary protein 3
COLGALT2 collagen beta(1-O)galactosyltransferase 2
DCAF4 DDB1 and CUL4 associated factor 4
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DET1 de-etiolated homolog 1 (Arabidopsis)
DNAAF2 dynein, axonemal, assembly factor 2
EFNA3 ephrin-A3
ELP6 elongator acetyltransferase complex subunit 6
EN2 engrailed homeobox 2
FADD Fas (TNFRSF6)-associated via death domain
FAM120C family with sequence similarity 120C
FANCF Fanconi anemia, complementation group F
FPGT fucose-1-phosphate guanylyltransferase
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GEMIN6 gem (nuclear organelle) associated protein 6
GRAMD1C GRAM domain containing 1C
HMGA2 high mobility group AT-hook 2
HPS6 Hermansky-Pudlak syndrome 6
IFT54 intraflagellar transport 54
ITPKB inositol-trisphosphate 3-kinase B
JRKL JRK-like
KIAA1107 KIAA1107
KIAA1456 KIAA1456
KLHL3 kelch-like family member 3
KRCC1 lysine-rich coiled-coil 1
LOC100127972 uncharacterized LOC100127972
LRRC8D leucine rich repeat containing 8 family, member D
LYPD3 LY6/PLAUR domain containing 3
MAGEF1 melanoma antigen family F1
MCTP2 multiple C2 domains, transmembrane 2
MN1 meningioma (disrupted in balanced translocation) 1
MOCS3 molybdenum cofactor synthesis 3
MUM1 melanoma associated antigen (mutated) 1
MXD3 MAX dimerization protein 3
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PALB2 partner and localizer of BRCA2
PDE12 phosphodiesterase 12
PLD2 phospholipase D2
POGK pogo transposable element with KRAB domain
PRB3 proline-rich protein BstNI subfamily 3
PRICKLE3 prickle homolog 3 (Drosophila)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPRE protein tyrosine phosphatase, receptor type, E
RBM15B RNA binding motif protein 15B
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RHOBTB1 Rho-related BTB domain containing 1
RHOBTB2 Rho-related BTB domain containing 2
RIBC2 RIB43A domain with coiled-coils 2
RIN2 Ras and Rab interactor 2
RPL23AP32 ribosomal protein L23a pseudogene 32
RPP40 ribonuclease P/MRP 40kDa subunit
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RSAD1 radical S-adenosyl methionine domain containing 1
RUFY2 RUN and FYVE domain containing 2
S100PBP S100P binding protein
SCD5 stearoyl-CoA desaturase 5
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SEPHS2 selenophosphate synthetase 2
SETMAR SET domain and mariner transposase fusion gene
SHROOM2 shroom family member 2
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SND1-IT1 SND1 intronic transcript 1
STON1 stonin 1
SYT17 synaptotagmin XVII
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMSB15A thymosin beta 15a
TTC30A tetratricopeptide repeat domain 30A
WDR25 WD repeat domain 25
WDR5B WD repeat domain 5B
ZBED8 zinc finger, BED-type containing 8
ZBTB3 zinc finger and BTB domain containing 3
ZFP30 ZFP30 zinc finger protein
ZFP69B ZFP69 zinc finger protein B
ZNF239 zinc finger protein 239
ZNF365 zinc finger protein 365
ZNF510 zinc finger protein 510
ZNF606 zinc finger protein 606
ZNF623 zinc finger protein 623
ZNF696 zinc finger protein 696