overall effect Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description disease cluster belonging to disease group cancer (Genetic Association Database)
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Genes

20 genes associated with the disease overall effect in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AURKA aurora kinase A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHEK2 checkpoint kinase 2
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
IGFBP3 insulin-like growth factor binding protein 3
MMP8 matrix metallopeptidase 8
PGR progesterone receptor
PRDM2 PR domain containing 2, with ZNF domain
RB1 retinoblastoma 1
SHBG sex hormone-binding globulin
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2