overnutrition Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Updated outdated UMLS CUI. (Human Disease Ontology, DOID_654)
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Genes

375 genes co-occuring with the disease overnutrition in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
LEP leptin 2.33549
MC4R melanocortin 4 receptor 2.22446
INS insulin 2.00929
GHRL ghrelin/obestatin prepropeptide 1.75596
LEPR leptin receptor 1.72867
SIM1 single-minded family bHLH transcription factor 1 1.56267
FTO fat mass and obesity associated 1.4022
AGRP agouti related neuropeptide 1.30095
PYY peptide YY 1.24168
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 1.22172
MC3R melanocortin 3 receptor 1.20137
CRP C-reactive protein, pentraxin-related 1.19532
PPARG peroxisome proliferator-activated receptor gamma 1.18798
PTH parathyroid hormone 1.15709
GIP gastric inhibitory polypeptide 1.13882
SH2B1 SH2B adaptor protein 1 1.11393
RETN resistin 1.10048
PCSK1 proprotein convertase subtilisin/kexin type 1 1.08118
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.05261
ADRB3 adrenoceptor beta 3 1.03367
POMC proopiomelanocortin 1.02735
NEGR1 neuronal growth regulator 1 0.974221
IGF1 insulin-like growth factor 1 (somatomedin C) 0.962891
TBC1D14 TBC1 domain family, member 14 0.959123
INSIG2 insulin induced gene 2 0.941611
IRS1 insulin receptor substrate 1 0.93
INSR insulin receptor 0.927519
AQP7 aquaporin 7 0.927105
MRAP2 melanocortin 2 receptor accessory protein 2 0.926692
NPY neuropeptide Y 0.9238
ALB albumin 0.912257
TRPV5 transient receptor potential cation channel, subfamily V, member 5 0.91061
PPY pancreatic polypeptide 0.900335
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.891308
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.885979
SHBG sex hormone-binding globulin 0.849536
OSBPL11 oxysterol binding protein-like 11 0.848307
KL klotho 0.847898
SREBF1 sterol regulatory element binding transcription factor 1 0.840934
GCG glucagon 0.834788
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 0.825768
LIPE lipase, hormone-sensitive 0.80977
FGF23 fibroblast growth factor 23 0.804846
IL6 interleukin 6 0.804436
TTR transthyretin 0.801974
SIRT1 sirtuin 1 0.777795
CCK cholecystokinin 0.769618
LPL lipoprotein lipase 0.757378
SOCS3 suppressor of cytokine signaling 3 0.750457
APMAP adipocyte plasma membrane associated protein 0.744766
ALPP alkaline phosphatase, placental 0.736649
ALPPL2 alkaline phosphatase, placental-like 2 0.736243
ALPL alkaline phosphatase, liver/bone/kidney 0.735027
SEC16B SEC16 homolog B (S. cerevisiae) 0.728143
KCTD15 potassium channel tetramerization domain containing 15 0.72612
GGT6 gamma-glutamyltransferase 6 0.720058
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 0.718039
KDM5D lysine (K)-specific demethylase 5D 0.710378
TNF tumor necrosis factor 0.695504
GIPR gastric inhibitory polypeptide receptor 0.689893
NAMPT nicotinamide phosphoribosyltransferase 0.688692
FABP2 fatty acid binding protein 2, intestinal 0.67113
FASN fatty acid synthase 0.669538
PLIN5 perilipin 5 0.660404
HCRT hypocretin (orexin) neuropeptide precursor 0.656441
MCHR2 melanin-concentrating hormone receptor 2 0.652089
GNPDA2 glucosamine-6-phosphate deaminase 2 0.650903
IRS2 insulin receptor substrate 2 0.650508
TULP2 tubby like protein 2 0.63907
KIAA1462 KIAA1462 0.635921
GCK glucokinase (hexokinase 4) 0.626888
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.625711
NPS neuropeptide S 0.625711
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.619051
LIPF lipase, gastric 0.59874
MTCH2 mitochondrial carrier 2 0.597571
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.580439
APOB apolipoprotein B 0.572662
RBP4 retinol binding protein 4, plasma 0.571495
TRPV6 transient receptor potential cation channel, subfamily V, member 6 0.567997
SYTL4 synaptotagmin-like 4 0.567997
BDNF brain-derived neurotrophic factor 0.565666
FTL ferritin, light polypeptide 0.565277
FTH1 ferritin, heavy polypeptide 1 0.565277
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.561004
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.556732
GAST gastrin 0.55518
ADIPOR2 adiponectin receptor 2 0.550911
ACSM3 acyl-CoA synthetase medium-chain family member 3 0.547807
IGLV3-21 immunoglobulin lambda variable 3-21 0.547807
CD79B CD79b molecule, immunoglobulin-associated beta 0.544705
NTS neurotensin 0.53928
FABP4 fatty acid binding protein 4, adipocyte 0.536183
CTNNBL1 catenin, beta like 1 0.530381
KISS1 KiSS-1 metastasis-suppressor 0.529994
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 0.522273
PRLHR prolactin releasing hormone receptor 0.510344
PLIN1 perilipin 1 0.508808
GGT1 gamma-glutamyltransferase 1 0.508041
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.504973
FAAH fatty acid amide hydrolase 0.504973
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.498085
PPARA peroxisome proliferator-activated receptor alpha 0.497321
COG2 component of oligomeric golgi complex 2 0.494648
BBS4 Bardet-Biedl syndrome 4 0.493503
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.488549
CCL2 chemokine (C-C motif) ligand 2 0.487407
PLG plasminogen 0.481705
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.481705
ITLN1 intelectin 1 (galactofuranose binding) 0.480186
RPL22 ribosomal protein L22 0.479807
ACACB acetyl-CoA carboxylase beta 0.478289
LYPLAL1 lysophospholipase-like 1 0.472604
AHSG alpha-2-HS-glycoprotein 0.469954
PACS1 phosphofurin acidic cluster sorting protein 1 0.468441
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.460129
BRD2 bromodomain containing 2 0.455978
MGAM maltase-glucoamylase 0.45447
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.448817
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.448441
GNAS GNAS complex locus 0.442418
IGFBP3 insulin-like growth factor binding protein 3 0.440914
MLXIP MLX interacting protein 0.438658
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.437154
ARL6 ADP-ribosylation factor-like 6 0.433397
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 0.433021
DSE dermatan sulfate epimerase 0.432646
GLS2 glutaminase 2 (liver, mitochondrial) 0.43227
APOA1 apolipoprotein A-I 0.428516
IL18 interleukin 18 0.42814
MTPAP mitochondrial poly(A) polymerase 0.427015
BBS1 Bardet-Biedl syndrome 1 0.42289
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.417644
PPARD peroxisome proliferator-activated receptor delta 0.416147
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.410535
PNPLA3 patatin-like phospholipase domain containing 3 0.408292
GHRH growth hormone releasing hormone 0.407172
GLP1R glucagon-like peptide 1 receptor 0.407172
SPP1 secreted phosphoprotein 1 0.401199
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.397098
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.396725
SEC24B SEC24 family member B 0.393374
FABP5 fatty acid binding protein 5 (psoriasis-associated) 0.392629
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.391513
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 0.391513
PNPLA2 patatin-like phospholipase domain containing 2 0.391141
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 0.388166
MLN motilin 0.382594
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2 0.380368
PROKR1 prokineticin receptor 1 0.378885
LCT lactase 0.372217
HOPX HOP homeobox 0.369997
CDCA8 cell division cycle associated 8 0.369258
CYB5R2 cytochrome b5 reductase 2 0.369258
FNDC5 fibronectin type III domain containing 5 0.368518
ANGPTL4 angiopoietin-like 4 0.363347
IGFBP1 insulin-like growth factor binding protein 1 0.362609
PNMA1 paraneoplastic Ma antigen 1 0.361502
CRTC1 CREB regulated transcription coactivator 1 0.361502
ETV5 ets variant 5 0.35892
RPGRIP1L RPGRIP1-like 0.349349
STEAP4 STEAP family member 4 0.347511
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.347144
DNAH8 dynein, axonemal, heavy chain 8 0.346777
BSX brain-specific homeobox 0.343473
GGTLC1 gamma-glutamyltransferase light chain 1 0.340906
GLP2R glucagon-like peptide 2 receptor 0.337975
NTF4 neurotrophin 4 0.33651
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.336144
DOCK5 dedicator of cytokinesis 5 0.333949
SDS serine dehydratase 0.332487
GGT2 gamma-glutamyltransferase 2 0.324823
SIRT3 sirtuin 3 0.321909
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.319363
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.312827
FAM120A family with sequence similarity 120A 0.312102
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.309928
SP6 Sp6 transcription factor 0.30631
STXBP3 syntaxin binding protein 3 0.305226
FHL1 four and a half LIM domains 1 0.300894
BGLAP bone gamma-carboxyglutamate (gla) protein 0.300894
GHR growth hormone receptor 0.299812
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.299452
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 0.298731
CRH corticotropin releasing hormone 0.296931
GGT5 gamma-glutamyltransferase 5 0.295851
CD36 CD36 molecule (thrombospondin receptor) 0.290103
NPY2R neuropeptide Y receptor Y2 0.289744
NMUR2 neuromedin U receptor 2 0.286519
GANAB glucosidase, alpha; neutral AB 0.285086
SPON2 spondin 2, extracellular matrix protein 0.282582
GLYAT glycine-N-acyltransferase 0.280082
SDF4 stromal cell derived factor 4 0.280082
CASS4 Cas scaffolding protein family member 4 0.279367
PCTP phosphatidylcholine transfer protein 0.276158
ARL13B ADP-ribosylation factor-like 13B 0.274021
DERA deoxyribose-phosphate aldolase (putative) 0.272953
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.27153
CNR1 cannabinoid receptor 1 (brain) 0.270819
GGT7 gamma-glutamyltransferase 7 0.270464
CPT1A carnitine palmitoyltransferase 1A (liver) 0.270464
TMEM18 transmembrane protein 18 0.268687
GPS2 G protein pathway suppressor 2 0.264785
GLUD1 glutamate dehydrogenase 1 0.260538
TBC1D4 TBC1 domain family, member 4 0.258417
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.253479
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.253127
CHD8 chromodomain helicase DNA binding protein 8 0.253127
DGKZ diacylglycerol kinase, zeta 0.252422
ADIPOR1 adiponectin receptor 1 0.250663
ALMS1 Alstrom syndrome protein 1 0.248554
GPS1 G protein pathway suppressor 1 0.245396
ZNF423 zinc finger protein 423 0.241546
APOC3 apolipoprotein C-III 0.23945
ZNF148 zinc finger protein 148 0.238403
SST somatostatin 0.238054
ADIPOQ adiponectin, C1Q and collagen domain containing 0.238054
EXOSC4 exosome component 4 0.235616
GIF gastric intrinsic factor (vitamin B synthesis) 0.235268
PRLH prolactin releasing hormone 0.234225
ERH enhancer of rudimentary homolog (Drosophila) 0.23353
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.232836
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.230755
IAPP islet amyloid polypeptide 0.230409
IRS4 insulin receptor substrate 4 0.230409
TF transferrin 0.229716
PTER phosphotriesterase related 0.229024
PRAMEF12 PRAME family member 12 0.227988
OSBP oxysterol binding protein 0.224884
REN renin 0.222479
RAB11A RAB11A, member RAS oncogene family 0.221108
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 0.221108
MC5R melanocortin 5 receptor 0.218034
DLK1 delta-like 1 homolog (Drosophila) 0.217352
NPC1 Niemann-Pick disease, type C1 0.215653
KIF1B kinesin family member 1B 0.210925
POLI polymerase (DNA directed) iota 0.208245
NPPB natriuretic peptide B 0.205254
RTN1 reticulon 1 0.202618
ACP5 acid phosphatase 5, tartrate resistant 0.200331
HOXB5 homeobox B5 0.199356
FOXJ2 forkhead box J2 0.199356
AKTIP AKT interacting protein 0.199033
JUN jun proto-oncogene 0.196139
LSM1 LSM1, U6 small nuclear RNA associated 0.19582
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) 0.191408
ENSA endosulfine alpha 0.190476
GATA4 GATA binding protein 4 0.190476
ITGAD integrin, alpha D 0.190168
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.18651
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.181798
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.18151
HADH hydroxyacyl-CoA dehydrogenase 0.180937
PRKCH protein kinase C, eta 0.180652
GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 0.180084
CTSS cathepsin S 0.179239
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 0.178682
IL33 interleukin 33 0.178403
PER1 period circadian clock 1 0.178403
PLAT plasminogen activator, tissue 0.178403
MT1E metallothionein 1E 0.177301
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.174093
SDC3 syndecan 3 0.172544
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.172291
STC2 stanniocalcin 2 0.172291
NRG1 neuregulin 1 0.171785
CCKAR cholecystokinin A receptor 0.171535
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.170789
IGF2 insulin-like growth factor 2 0.169812
NRXN3 neurexin 3 0.169812
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.168381
ADRA2B adrenoceptor alpha 2B 0.168381
F2 coagulation factor II (thrombin) 0.168381
ASCL1 achaete-scute family bHLH transcription factor 1 0.167452
CNTFR ciliary neurotrophic factor receptor 0.166768
SCARB1 scavenger receptor class B, member 1 0.166768
CD40LG CD40 ligand 0.166544
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 0.166319
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.165874
MLXIPL MLX interacting protein-like 0.165655
XBP1 X-box binding protein 1 0.163938
TRAPPC9 trafficking protein particle complex 9 0.163729
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.163523
PFKM phosphofructokinase, muscle 0.163111
BBS12 Bardet-Biedl syndrome 12 0.162505
NR1H2 nuclear receptor subfamily 1, group H, member 2 0.161912
FGF21 fibroblast growth factor 21 0.161523
JAK2 Janus kinase 2 0.161139
PLIN3 perilipin 3 0.160948
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.160387
PRRC2A proline-rich coiled-coil 2A 0.160387
BBS10 Bardet-Biedl syndrome 10 0.160387
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.160203
LRRC38 leucine rich repeat containing 38 0.160203
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.159658
STEAP1 six transmembrane epithelial antigen of the prostate 1 0.158605
MIR130B microRNA 130b 0.158434
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.157602
CALB1 calbindin 1, 28kDa 0.140274
RARG retinoic acid receptor, gamma 0.139629
IL17C interleukin 17C 0.139405
DCT dopachrome tautomerase 0.138694
SET SET nuclear proto-oncogene 0.138412
CLCN7 chloride channel, voltage-sensitive 7 0.13817
IGFBP4 insulin-like growth factor binding protein 4 0.137821
NRIP1 nuclear receptor interacting protein 1 0.137765
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.137534
GANC glucosidase, alpha; neutral C 0.137461
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.137386
FAIM2 Fas apoptotic inhibitory molecule 2 0.137311
RBP1 retinol binding protein 1, cellular 0.137304
CHMP2A charged multivesicular body protein 2A 0.137273
UBA1 ubiquitin-like modifier activating enzyme 1 0.137204
APOA2 apolipoprotein A-II 0.137204
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 0.137189
RFX5 regulatory factor X, 5 (influences HLA class II expression) 0.137158
NNAT neuronatin 0.137049
TDO2 tryptophan 2,3-dioxygenase 0.136883
ICK intestinal cell (MAK-like) kinase 0.136746
MCHR1 melanin-concentrating hormone receptor 1 0.136647
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 0.136531
AQP9 aquaporin 9 0.136463
DPP4 dipeptidyl-peptidase 4 0.136429
PDLIM1 PDZ and LIM domain 1 0.136395
RARS arginyl-tRNA synthetase 0.136275
STC1 stanniocalcin 1 0.136179
MT1A metallothionein 1A 0.136135
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.135865
TMEM245 transmembrane protein 245 0.135698
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 0.135586
OLFM4 olfactomedin 4 0.13549
DMRTA1 DMRT-like family A1 0.135471
CALCA calcitonin-related polypeptide alpha 0.135375
ADCY3 adenylate cyclase 3 0.135356
ADRB2 adrenoceptor beta 2, surface 0.135356
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 0.135336
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.135277
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.135179
ACSL1 acyl-CoA synthetase long-chain family member 1 0.135149
PNLIP pancreatic lipase 0.135078
GLB1 galactosidase, beta 1 0.135028
GSR glutathione reductase 0.134833
SNAP25 synaptosomal-associated protein, 25kDa 0.134708
MGP matrix Gla protein 0.13457
BMP2 bone morphogenetic protein 2 0.134463
PEX10 peroxisomal biogenesis factor 10 0.134386
CLEC2A C-type lectin domain family 2, member A 0.134076
ATP11A ATPase, class VI, type 11A 0.133812
SALL4 spalt-like transcription factor 4 0.133671
EFS embryonal Fyn-associated substrate 0.133123
HMGB1 high mobility group box 1 0.131401
PHEX phosphate regulating endopeptidase homolog, X-linked 0.130596
HAND2 heart and neural crest derivatives expressed 2 0.130037
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.12959
MDH1 malate dehydrogenase 1, NAD (soluble) 0.128885
LRP2 low density lipoprotein receptor-related protein 2 0.128234
PTHLH parathyroid hormone-like hormone 0.127795
HK1 hexokinase 1 0.127237
IL11 interleukin 11 0.126319
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 0.1256
CSN1S1 casein alpha s1 0.12497
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.124185
OAT ornithine aminotransferase 0.122319
SOX9 SRY (sex determining region Y)-box 9 0.121063
GAA glucosidase, alpha; acid 0.120114
TAT tyrosine aminotransferase 0.119819
IVL involucrin 0.118322
BMP4 bone morphogenetic protein 4 0.117461
GJB2 gap junction protein, beta 2, 26kDa 0.116983
CA2 carbonic anhydrase II 0.115761
COL1A1 collagen, type I, alpha 1 0.115644
PKLR pyruvate kinase, liver and RBC 0.114646
RARA retinoic acid receptor, alpha 0.113138
RUNX2 runt-related transcription factor 2 0.111054
ODC1 ornithine decarboxylase 1 0.10979