oxyphenbutazone-3582 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the oxyphenbutazone-3582 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD17B abhydrolase domain containing 17B
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADM adrenomedullin
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
APOM apolipoprotein M
ARHGAP35 Rho GTPase activating protein 35
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
BGN biglycan
BIN1 bridging integrator 1
BMP2 bone morphogenetic protein 2
C11ORF21 chromosome 11 open reading frame 21
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CBR3 carbonyl reductase 3
CDA cytidine deaminase
CDC14A cell division cycle 14A
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CES3 carboxylesterase 3
CHM choroideremia (Rab escort protein 1)
CLCN6 chloride channel, voltage-sensitive 6
CREM cAMP responsive element modulator
CRHR2 corticotropin releasing hormone receptor 2
CSRP2 cysteine and glycine-rich protein 2
DCN decorin
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DOK4 docking protein 4
EFNA3 ephrin-A3
ELAC2 elaC ribonuclease Z 2
ERCC6 excision repair cross-complementation group 6
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FRMD1 FERM domain containing 1
GCLM glutamate-cysteine ligase, modifier subunit
GM2A GM2 ganglioside activator
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GSPT1 G1 to S phase transition 1
HMOX1 heme oxygenase 1
HOXA1 homeobox A1
IL1B interleukin 1, beta
INHBE inhibin, beta E
KAT5 K(lysine) acetyltransferase 5
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLF9 Kruppel-like factor 9
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAP1B microtubule-associated protein 1B
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIER2 mesoderm induction early response 1, family member 2
MIR22HG MIR22 host gene
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
NADK NAD kinase
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDRG1 N-myc downstream regulated 1
NF1 neurofibromin 1
OSGIN1 oxidative stress induced growth inhibitor 1
PAIP2B poly(A) binding protein interacting protein 2B
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POFUT1 protein O-fucosyltransferase 1
PRAMEF11 PRAME family member 11
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PTN pleiotrophin
QKI QKI, KH domain containing, RNA binding
RIMS3 regulating synaptic membrane exocytosis 3
RNF6 ring finger protein (C3H2C3 type) 6
RPL23AP32 ribosomal protein L23a pseudogene 32
RUNX1 runt-related transcription factor 1
SIX2 SIX homeobox 2
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON1 spondin 1, extracellular matrix protein
STYK1 serine/threonine/tyrosine kinase 1
SYNJ2 synaptojanin 2
TES testin LIM domain protein
TM4SF5 transmembrane 4 L six family member 5
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM144 transmembrane protein 144
TOX4 TOX high mobility group box family member 4
TPSG1 tryptase gamma 1
TXNRD1 thioredoxin reductase 1
ULBP2 UL16 binding protein 2
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZBED4 zinc finger, BED-type containing 4
ZFP36L2 ZFP36 ring finger protein-like 2
ZG16 zymogen granule protein 16
ZNF112 zinc finger protein 112
ZNF250 zinc finger protein 250
ZNF329 zinc finger protein 329
ZNF639 zinc finger protein 639
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ACTL8 actin-like 8
ADRA2C adrenoceptor alpha 2C
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALPK1 alpha-kinase 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARMCX2 armadillo repeat containing, X-linked 2
ARPIN actin-related protein 2/3 complex inhibitor
ARRB2 arrestin, beta 2
BIRC7 baculoviral IAP repeat containing 7
BMP4 bone morphogenetic protein 4
BTF3P11 basic transcription factor 3 pseudogene 11
C5AR2 complement component 5a receptor 2
CD70 CD70 molecule
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CIDEB cell death-inducing DFFA-like effector b
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLSPN claspin
CORT cortistatin
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUZD1 CUB and zona pellucida-like domains 1
DAGLA diacylglycerol lipase, alpha
ENO3 enolase 3 (beta, muscle)
EPYC epiphycan
ERCC4 excision repair cross-complementation group 4
ERN1 endoplasmic reticulum to nucleus signaling 1
EXTL2 exostosin-like glycosyltransferase 2
FAM155A family with sequence similarity 155, member A
FANCE Fanconi anemia, complementation group E
FBRS fibrosin
FBXL7 F-box and leucine-rich repeat protein 7
FGF23 fibroblast growth factor 23
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GAMT guanidinoacetate N-methyltransferase
GINS4 GINS complex subunit 4 (Sld5 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GPATCH3 G patch domain containing 3
GPC3 glypican 3
GSTT1 glutathione S-transferase theta 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HAMP hepcidin antimicrobial peptide
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H4F histone cluster 1, H4f
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXC10 homeobox C10
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IGFBP6 insulin-like growth factor binding protein 6
IL22 interleukin 22
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0125 KIAA0125
KIAA0319L KIAA0319-like
KIF13B kinesin family member 13B
KPNA5 karyopherin alpha 5 (importin alpha 6)
LINC00597 long intergenic non-protein coding RNA 597
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MRPL41 mitochondrial ribosomal protein L41
MXD3 MAX dimerization protein 3
MYO1F myosin IF
NHEJ1 nonhomologous end-joining factor 1
NLGN1 neuroligin 1
NLRX1 NLR family member X1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPFFR1 neuropeptide FF receptor 1
NRTN neurturin
NXPH4 neurexophilin 4
NYNRIN NYN domain and retroviral integrase containing
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PADI1 peptidyl arginine deiminase, type I
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PGP phosphoglycolate phosphatase
PLA2G1B phospholipase A2, group IB (pancreas)
PTDSS2 phosphatidylserine synthase 2
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RNF126P1 ring finger protein 126 pseudogene 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RUSC2 RUN and SH3 domain containing 2
SALL2 spalt-like transcription factor 2
SCG2 secretogranin II
SCUBE3 signal peptide, CUB domain, EGF-like 3
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERGEF secretion regulating guanine nucleotide exchange factor
SLC12A8 solute carrier family 12, member 8
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPINK4 serine peptidase inhibitor, Kazal type 4
TDRD1 tudor domain containing 1
THRAP3 thyroid hormone receptor associated protein 3
TLR5 toll-like receptor 5
TMEM121 transmembrane protein 121
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TNRC6B trinucleotide repeat containing 6B
TUBA3C tubulin, alpha 3c
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USB1 U6 snRNA biogenesis 1
ZBTB48 zinc finger and BTB domain containing 48
ZNF652 zinc finger protein 652
ZNF750 zinc finger protein 750