p53 signaling pathway Gene Set

Dataset Biocarta Pathways
Category structural or functional annotations
Type pathway
Description p53 transcription factor is a tumor suppressor frequently mutated in cancer. p53 is at the hub of many signaling and regulatory pathways. In response to various stresses, it promotes apoptosis, cell cycle arrest and other defense pathways via transcription dependent as well as independent routes. A key regulator of p53 is Mdm2. Mdm2 is a transcriptional target of p53 thus providing a negative feedback loop. (Pathway Ontology, PW_0000718)
External Link http://cgap.nci.nih.gov/Pathways/BioCarta/h_p53Pathway
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13 proteins participating in the p53 signaling pathway pathway from the Biocarta Pathways dataset.

Symbol Name
BCL2 B-cell CLL/lymphoma 2
CCND1 cyclin D1
CCNE1 cyclin E1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
E2F1 E2F transcription factor 1
GADD45A growth arrest and DNA-damage-inducible, alpha
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
PCNA proliferating cell nuclear antigen
RB1 retinoblastoma 1
TIMP3 TIMP metallopeptidase inhibitor 3
TP53 tumor protein p53