paclitaxel-6720 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the paclitaxel-6720 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACSS3 acyl-CoA synthetase short-chain family member 3
ADAM29 ADAM metallopeptidase domain 29
AGFG1 ArfGAP with FG repeats 1
AIM1L absent in melanoma 1-like
ANKRD12 ankyrin repeat domain 12
APAF1 apoptotic peptidase activating factor 1
APC adenomatous polyposis coli
ATXN7L1 ataxin 7-like 1
AURKA aurora kinase A
C10ORF12 chromosome 10 open reading frame 12
CALD1 caldesmon 1
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD58 CD58 molecule
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP290 centrosomal protein 290kDa
CISH cytokine inducible SH2-containing protein
CLCC1 chloride channel CLIC-like 1
COBL cordon-bleu WH2 repeat protein
CRMP1 collapsin response mediator protein 1
CTNS cystinosin, lysosomal cystine transporter
CYTH3 cytohesin 3
DLX2 distal-less homeobox 2
DLX4 distal-less homeobox 4
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
ERAP1 endoplasmic reticulum aminopeptidase 1
EZR ezrin
FAM46C family with sequence similarity 46, member C
GPR22 G protein-coupled receptor 22
GUK1 guanylate kinase 1
H2AFX H2A histone family, member X
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IFT74 intraflagellar transport 74
IGSF6 immunoglobulin superfamily, member 6
INSIG1 insulin induced gene 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA1024 KIAA1024
KLK13 kallikrein-related peptidase 13
KRIT1 KRIT1, ankyrin repeat containing
KRT10 keratin 10, type I
LARP7 La ribonucleoprotein domain family, member 7
LDB1 LIM domain binding 1
LRRC15 leucine rich repeat containing 15
MAGEA5 melanoma antigen family A5
MAN1A2 mannosidase, alpha, class 1A, member 2
MCTP2 multiple C2 domains, transmembrane 2
MFAP3L microfibrillar-associated protein 3-like
MRPL52 mitochondrial ribosomal protein L52
NOP16 NOP16 nucleolar protein
NPEPPS aminopeptidase puromycin sensitive
NTF3 neurotrophin 3
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OAZ3 ornithine decarboxylase antizyme 3
PAOX polyamine oxidase (exo-N4-amino)
PCNX pecanex homolog (Drosophila)
PDE10A phosphodiesterase 10A
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIP prolactin-induced protein
PKP4 plakophilin 4
PLAGL1 pleiomorphic adenoma gene-like 1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PRRC2C proline-rich coiled-coil 2C
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RPE65 retinal pigment epithelium-specific protein 65kDa
RPL10 ribosomal protein L10
RPL14 ribosomal protein L14
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SAP30 Sin3A-associated protein, 30kDa
SAYSD1 SAYSVFN motif domain containing 1
SCML2 sex comb on midleg-like 2 (Drosophila)
SEPP1 selenoprotein P, plasma, 1
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
STK17A serine/threonine kinase 17a
TBXA2R thromboxane A2 receptor
TFG TRK-fused gene
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB2 transforming growth factor, beta 2
TM2D1 TM2 domain containing 1
TM6SF1 transmembrane 6 superfamily member 1
TMCO6 transmembrane and coiled-coil domains 6
TMPRSS4 transmembrane protease, serine 4
TRAM1 translocation associated membrane protein 1
TRIM14 tripartite motif containing 14
TWIST1 twist family bHLH transcription factor 1
UBE2I ubiquitin-conjugating enzyme E2I
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
VWA5A von Willebrand factor A domain containing 5A
WDR78 WD repeat domain 78
ZFP30 ZFP30 zinc finger protein
ZNF500 zinc finger protein 500

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADAM15 ADAM metallopeptidase domain 15
AKIP1 A kinase (PRKA) interacting protein 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BCAS3 breast carcinoma amplified sequence 3
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CA5BP1 carbonic anhydrase VB pseudogene 1
CAMTA2 calmodulin binding transcription activator 2
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CD70 CD70 molecule
CEP131 centrosomal protein 131kDa
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLDN14 claudin 14
CLDN4 claudin 4
CORO1A coronin, actin binding protein, 1A
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CRABP2 cellular retinoic acid binding protein 2
CUEDC1 CUE domain containing 1
DDA1 DET1 and DDB1 associated 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DEAF1 DEAF1 transcription factor
DNAL4 dynein, axonemal, light chain 4
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EMP3 epithelial membrane protein 3
FBXL6 F-box and leucine-rich repeat protein 6
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FKBP5 FK506 binding protein 5
FNTB farnesyltransferase, CAAX box, beta
GAMT guanidinoacetate N-methyltransferase
GCHFR GTP cyclohydrolase I feedback regulator
GINS4 GINS complex subunit 4 (Sld5 homolog)
GPR176 G protein-coupled receptor 176
GYS1 glycogen synthase 1 (muscle)
H2BFS H2B histone family, member S (pseudogene)
HDAC5 histone deacetylase 5
HIST3H2A histone cluster 3, H2a
HOXA4 homeobox A4
HYAL2 hyaluronoglucosaminidase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IL4R interleukin 4 receptor
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KPNA5 karyopherin alpha 5 (importin alpha 6)
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT8P12 keratin 8 pseudogene 12
LRRC61 leucine rich repeat containing 61
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
MBTPS1 membrane-bound transcription factor peptidase, site 1
MED24 mediator complex subunit 24
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MYL5 myosin, light chain 5, regulatory
MYL9 myosin, light chain 9, regulatory
NABP2 nucleic acid binding protein 2
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NRGN neurogranin (protein kinase C substrate, RC3)
PES1 pescadillo ribosomal biogenesis factor 1
PFN1 profilin 1
PKM pyruvate kinase, muscle
PKN1 protein kinase N1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHO1 pleckstrin homology domain containing, family O member 1
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLM polymerase (DNA directed), mu
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
QTRT1 queuine tRNA-ribosyltransferase 1
RNF113A ring finger protein 113A
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPL11 ribosomal protein L11
RPP25 ribonuclease P/MRP 25kDa subunit
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
S100A4 S100 calcium binding protein A4
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPAG7 sperm associated antigen 7
SPTBN2 spectrin, beta, non-erythrocytic 2
STK16 serine/threonine kinase 16
SUGCT succinyl-CoA:glutarate-CoA transferase
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBC1D17 TBC1 domain family, member 17
TMEM120B transmembrane protein 120B
TMEM8A transmembrane protein 8A
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TRAPPC2L trafficking protein particle complex 2-like
TRPM2 transient receptor potential cation channel, subfamily M, member 2
UBA1 ubiquitin-like modifier activating enzyme 1
UBTF upstream binding transcription factor, RNA polymerase I
ULBP2 UL16 binding protein 2
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZNF408 zinc finger protein 408