paclitaxel Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark. (Chemical Entities of Biological Interest Ontology, CHEBI_45863)
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Genes

141 genes co-occuring with the biological term paclitaxel in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANXA4 annexin A4
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BECN1 beclin 1, autophagy related
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCNB1 cyclin B1
CCNB2 cyclin B2
CD276 CD276 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CLIP1 CAP-GLY domain containing linker protein 1
CLU clusterin
CTGF connective tissue growth factor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DAXX death-domain associated protein
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DPP4 dipeptidyl-peptidase 4
E2F1 E2F transcription factor 1
E2F3 E2F transcription factor 3
EGFR epidermal growth factor receptor
EGR1 early growth response 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FHIT fragile histidine triad
FOXO3 forkhead box O3
GDI1 GDP dissociation inhibitor 1
GJB2 gap junction protein, beta 2, 26kDa
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSTP1 glutathione S-transferase pi 1
GTSE1 G-2 and S-phase expressed 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HRAS Harvey rat sarcoma viral oncogene homolog
HSF1 heat shock transcription factor 1
HSPB2 heat shock 27kDa protein 2
HTRA1 HtrA serine peptidase 1
IGFBP3 insulin-like growth factor binding protein 3
IL12A interleukin 12A
IL2 interleukin 2
IL6 interleukin 6
KIF11 kinesin family member 11
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT18 keratin 18, type I
LAMP2 lysosomal-associated membrane protein 2
LTB4R2 leukotriene B4 receptor 2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MET MET proto-oncogene, receptor tyrosine kinase
MIR106A microRNA 106a
MIR125B1 microRNA 125b-1
MIR125B2 microRNA 125b-2
MIR148A microRNA 148a
MIR17 microRNA 17
MIR30A microRNA 30a
MIR34C microRNA 34c
MIR367 microRNA 367
MIR375 microRNA 375
MIR591 microRNA 591
MMP9 matrix metallopeptidase 9
MSLN mesothelin
MYD88 myeloid differentiation primary response 88
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NEK2 NIMA-related kinase 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NINL ninein-like
NOTCH1 notch 1
PADI2 peptidyl arginine deiminase, type II
PDIA3 protein disulfide isomerase family A, member 3
PHB prohibitin
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PLK2 polo-like kinase 2
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRC1 protein regulator of cytokinesis 1
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RSF1 remodeling and spacing factor 1
RWDD3 RWD domain containing 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SFN stratifin
SHH sonic hedgehog
SIX1 SIX homeobox 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLPI secretory leukocyte peptidase inhibitor
SMOX spermine oxidase
SPAG5 sperm associated antigen 5
SPDEF SAM pointed domain containing ETS transcription factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STMN3 stathmin-like 3
TACC3 transforming, acidic coiled-coil containing protein 3
TECTA tectorin alpha
TGFBI transforming growth factor, beta-induced, 68kDa
THBD thrombomodulin
TIMP1 TIMP metallopeptidase inhibitor 1
TNS4 tensin 4
TP53 tumor protein p53
TUBB tubulin, beta class I
TUBB1 tubulin, beta 1 class VI
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TYMP thymidine phosphorylase
TYMS thymidylate synthetase
UBE3A ubiquitin protein ligase E3A
YBX1 Y box binding protein 1