paclitaxel Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark. (Chemical Entities of Biological Interest Ontology, CHEBI_45863)
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Genes

58 proteins co-occuring with the biological term paclitaxel in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANXA2 annexin A2
ATF2 activating transcription factor 2
AURKA aurora kinase A
AURKB aurora kinase B
BAD BCL2-associated agonist of cell death
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BIRC5 baculoviral IAP repeat containing 5
CAV1 caveolin 1, caveolae protein, 22kDa
CDC25C cell division cycle 25C
CDH5 cadherin 5, type 2 (vascular endothelium)
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CEP250 centrosomal protein 250kDa
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
DCTN1 dynactin 1
DEPTOR DEP domain containing MTOR-interacting protein
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FADD Fas (TNFRSF6)-associated via death domain
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HIST1H3A histone cluster 1, H3a
INCENP inner centromere protein antigens 135/155kDa
JUN jun proto-oncogene
KIF2C kinesin family member 2C
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MCL1 myeloid cell leukemia 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PTK2B protein tyrosine kinase 2 beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1 retinoblastoma 1
RHOA ras homolog family member A
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SMAD3 SMAD family member 3
SMC1A structural maintenance of chromosomes 1A
SPAG5 sperm associated antigen 5
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TP53 tumor protein p53
TPT1 tumor protein, translationally-controlled 1
TWIST1 twist family bHLH transcription factor 1
WWC1 WW and C2 domain containing 1