phosphofurin acidic cluster sorting protein 1|This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 55690)
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8 genes co-occuring with the biological term pacs1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
