pain Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. (Experimental Factor Ontology, EFO_0003843)
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Genes

215 genes co-occuring with the biological term pain in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACAN aggrecan
ACE angiotensin I converting enzyme
ACPP acid phosphatase, prostate
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADRA1A adrenoceptor alpha 1A
ADRA2A adrenoceptor alpha 2A
ADRA2C adrenoceptor alpha 2C
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRBK1 adrenergic, beta, receptor kinase 1
AGTR2 angiotensin II receptor, type 2
ALB albumin
AMY1A amylase, alpha 1A (salivary)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA1 annexin A1
APP amyloid beta (A4) precursor protein
AQP1 aquaporin 1 (Colton blood group)
ASIC1 acid sensing (proton gated) ion channel 1
ASIC3 acid sensing (proton gated) ion channel 3
AVP arginine vasopressin
AVPR1A arginine vasopressin receptor 1A
AZU1 azurocidin 1
BDKRB1 bradykinin receptor B1
BDNF brain-derived neurotrophic factor
BMP2 bone morphogenetic protein 2
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CALCA calcitonin-related polypeptide alpha
CALCB calcitonin-related polypeptide beta
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CD1A CD1a molecule
CD40LG CD40 ligand
CD83 CD83 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK5 cyclin-dependent kinase 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRM2 cholinergic receptor, muscarinic 2
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCN1 chloride channel, voltage-sensitive 1
CMKLR1 chemerin chemokine-like receptor 1
CNR1 cannabinoid receptor 1 (brain)
COL2A1 collagen, type II, alpha 1
COMT catechol-O-methyltransferase
CPA3 carboxypeptidase A3 (mast cell)
CRP C-reactive protein, pentraxin-related
CST3 cystatin C
CTSS cathepsin S
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DMD dystrophin
DPP3 dipeptidyl-peptidase 3
DRD2 dopamine receptor D2
EDN1 endothelin 1
ESR1 estrogen receptor 1
F12 coagulation factor XII (Hageman factor)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAAH fatty acid amide hydrolase
FABP3 fatty acid binding protein 3, muscle and heart
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FKBP5 FK506 binding protein 5
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FZD3 frizzled class receptor 3
GAL galanin/GMAP prepropeptide
GCH1 GTP cyclohydrolase 1
GDF5 growth differentiation factor 5
GFRA2 GDNF family receptor alpha 2
GHRL ghrelin/obestatin prepropeptide
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GP6 glycoprotein VI (platelet)
GPER1 G protein-coupled estrogen receptor 1
GPR68 G protein-coupled receptor 68
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
HLA-B major histocompatibility complex, class I, B
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HPSE heparanase
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
IDO1 indoleamine 2,3-dioxygenase 1
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
IL18 interleukin 18
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
IL3 interleukin 3
IL6 interleukin 6
IL6R interleukin 6 receptor
INHBB inhibin, beta B
ITGA6 integrin, alpha 6
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4
KCNIP3 Kv channel interacting protein 3, calsenilin
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCNK9 potassium channel, two pore domain subfamily K, member 9
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LTA lymphotoxin alpha
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MECP2 methyl CpG binding protein 2
MEFV Mediterranean fever
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR219A1 microRNA 219a-1
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MT-TK tRNA
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NLRP3 NLR family, pyrin domain containing 3
NPBWR1 neuropeptides B/W receptor 1
NPFF neuropeptide FF-amide peptide precursor
NPPB natriuretic peptide B
NRTN neurturin
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRM1 opioid receptor, mu 1
OXT oxytocin/neurophysin I prepropeptide
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAEP progestagen-associated endometrial protein
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDYN prodynorphin
PGF placental growth factor
PKLR pyruvate kinase, liver and RBC
POMC proopiomelanocortin
PPARG peroxisome proliferator-activated receptor gamma
PROK2 prokineticin 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RET ret proto-oncogene
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S1PR3 sphingosine-1-phosphate receptor 3
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN11A sodium channel, voltage gated, type XI alpha subunit
SCN4A sodium channel, voltage gated, type IV alpha subunit
SCN4B sodium channel, voltage gated, type IV beta subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SCN9A sodium channel, voltage gated, type IX alpha subunit
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TCL1A T-cell leukemia/lymphoma 1A
TGFB1 transforming growth factor, beta 1
THBS4 thrombospondin 4
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNNT2 troponin T type 2 (cardiac)
TPSAB1 tryptase alpha/beta 1
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TRPV4 transient receptor potential cation channel, subfamily V, member 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
VEGFA vascular endothelial growth factor A
WNK1 WNK lysine deficient protein kinase 1
WNT3A wingless-type MMTV integration site family, member 3A
WT1 Wilms tumor 1