pak1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description p21 protein (Cdc42/Rac)-activated kinase 1|This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] (NCBI Entrez Gene Database, 5058)
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Genes

88 genes co-occuring with the biological term pak1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
AKT1 v-akt murine thymoma viral oncogene homolog 1
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
BAD BCL2-associated agonist of cell death
BBC3 BCL2 binding component 3
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C11ORF30 chromosome 11 open reading frame 30
CAPN5 calpain 5
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCND1 cyclin D1
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK11A cyclin-dependent kinase 11A
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CIB1 calcium and integrin binding 1 (calmyrin)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTBP1 C-terminal binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DGKZ diacylglycerol kinase, zeta
DNM1 dynamin 1
DYNLL1 dynein, light chain, LC8-type 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
F3 coagulation factor III (thromboplastin, tissue factor)
FLNA filamin A, alpha
FOXO1 forkhead box O1
GCG glucagon
GJA1 gap junction protein, alpha 1, 43kDa
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GRB2 growth factor receptor-bound protein 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HOXD10 homeobox D10
HTT huntingtin
ILK integrin-linked kinase
INPP5K inositol polyphosphate-5-phosphatase K
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KALRN kalirin, RhoGEF kinase
KIF2C kinesin family member 2C
KLF6 Kruppel-like factor 6
KRAS Kirsten rat sarcoma viral oncogene homolog
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MET MET proto-oncogene, receptor tyrosine kinase
MIR221 microRNA 221
MIR7-1 microRNA 7-1
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MYH10 myosin, heavy chain 10, non-muscle
NCK1 NCK adaptor protein 1
NELFCD negative elongation factor complex member C/D
NET1 neuroepithelial cell transforming 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDPK1 3-phosphoinositide dependent protein kinase 1
PGM1 phosphoglucomutase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PRKCZ protein kinase C, zeta
PRL prolactin
PTK2 protein tyrosine kinase 2
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOA ras homolog family member A
RHOJ ras homolog family member J
RHOV ras homolog family member V
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SMAD4 SMAD family member 4
SNAI1 snail family zinc finger 1
SORBS2 sorbin and SH3 domain containing 2
STK11 serine/threonine kinase 11
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNF tumor necrosis factor
TRIO trio Rho guanine nucleotide exchange factor
WASF2 WAS protein family, member 2