pak2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description p21 protein (Cdc42/Rac)-activated kinase 2|The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5062)
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Genes

23 genes co-occuring with the biological term pak2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ARHGAP10 Rho GTPase activating protein 10
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD4 CD4 molecule
CDC42 cell division cycle 42
CFL1 cofilin 1 (non-muscle)
DLG1 discs, large homolog 1 (Drosophila)
F2 coagulation factor II (thrombin)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIRA histone cell cycle regulator
HIST4H4 histone cluster 4, H4
MAP2K1 mitogen-activated protein kinase kinase 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PKN2 protein kinase N2
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCE protein kinase C, epsilon
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
SMAD1 SMAD family member 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYK spleen tyrosine kinase
TGFB1 transforming growth factor, beta 1