pak4 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description p21 protein (Cdc42/Rac)-activated kinase 4|PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10298)
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Genes

31 genes co-occuring with the biological term pak4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
CASP8 caspase 8, apoptosis-related cysteine peptidase
CDC42 cell division cycle 42
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CFL1 cofilin 1 (non-muscle)
CTNND1 catenin (cadherin-associated protein), delta 1
DGCR6L DiGeorge syndrome critical region gene 6-like
FGF7 fibroblast growth factor 7
FGFR2 fibroblast growth factor receptor 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
ITGAV integrin, alpha V
ITGB5 integrin, beta 5
KRAS Kirsten rat sarcoma viral oncogene homolog
LIMK1 LIM domain kinase 1
MIR145 microRNA 145
MMP2 matrix metallopeptidase 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PARD6B par-6 family cell polarity regulator beta
PRKCE protein kinase C, epsilon
PRKD1 protein kinase D1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RIOK3 RIO kinase 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSH1 slingshot protein phosphatase 1
STK26 serine/threonine protein kinase 26
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRADD TNFRSF1A-associated via death domain