| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | palbociclib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the palbociclib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PODXL | podocalyxin-like | 0.293722 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.208651 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.176336 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.103964 |
| AHNAK | AHNAK nucleoprotein | 0.0841032 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0825331 |
| FLNB | filamin B, beta | 0.0812757 |
| PLAT | plasminogen activator, tissue | 0.0760406 |
| HLA-B | major histocompatibility complex, class I, B | 0.0750317 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0733363 |
| MAP1B | microtubule-associated protein 1B | 0.0675785 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0632967 |
| FSTL1 | follistatin-like 1 | 0.0625302 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0617866 |
| HDAC9 | histone deacetylase 9 | 0.0555588 |
| ACTG1 | actin gamma 1 | 0.0553769 |
| DCLK2 | doublecortin-like kinase 2 | 0.0542528 |
| COL5A1 | collagen, type V, alpha 1 | 0.0532931 |
| PLEC | plectin | 0.0500073 |
| SQSTM1 | sequestosome 1 | 0.0492507 |
| LOXL2 | lysyl oxidase-like 2 | 0.0472233 |
| DST | dystonin | 0.0470647 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0466126 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0461488 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0443495 |
| TLE4 | transducin-like enhancer of split 4 | 0.0435034 |
| EGFR | epidermal growth factor receptor | 0.0434579 |
| FLNA | filamin A, alpha | 0.0431092 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0429198 |
| MYOF | myoferlin | 0.0421799 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0417204 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0412834 |
| THBS2 | thrombospondin 2 | 0.0405193 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.039086 |
| CAVIN1 | caveolae associated protein 1 | 0.0382633 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0379069 |
| KRT18 | keratin 18, type I | 0.0378395 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0376076 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0371545 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0361391 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0355307 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0344649 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.034309 |
| RUNX1 | runt-related transcription factor 1 | 0.034099 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0331454 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0329431 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0328105 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0323808 |
| CANX | calnexin | 0.0316542 |
| PGK1 | phosphoglycerate kinase 1 | 0.030981 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0307932 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0307727 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0306339 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0302927 |
| HLA-C | major histocompatibility complex, class I, C | 0.0302781 |
| L1CAM | L1 cell adhesion molecule | 0.0301885 |
| RND3 | Rho family GTPase 3 | 0.0300912 |
| RNF213 | ring finger protein 213 | 0.0298367 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0297316 |
| SEPTIN9 | septin 9 | 0.0297227 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0295958 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0291923 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0285443 |
| PCDH7 | protocadherin 7 | 0.0281894 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0279451 |
| TRAM2 | translocation associated membrane protein 2 | 0.0279074 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0273128 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0265127 |
| EXOC6B | exocyst complex component 6B | 0.0261618 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0259479 |
| OGA | O-GlcNAcase | 0.0258804 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0258784 |
| CSTB | cystatin B (stefin B) | 0.0252741 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0247526 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0245048 |
| NEK7 | NIMA-related kinase 7 | 0.0243622 |
| PRELID2 | PRELI domain containing 2 | 0.0242083 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0241782 |
| ARFGEF3 | ARFGEF family member 3 | 0.023717 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0236736 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | 0.0233954 |
| FMN2 | formin 2 | 0.0231483 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.022731 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0225722 |
| PFKP | phosphofructokinase, platelet | 0.0225288 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0223288 |
| TUFT1 | tuftelin 1 | 0.0222948 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | 0.02197 |
| TMSB4X | thymosin beta 4, X-linked | 0.0215317 |
| KRT8 | keratin 8, type II | 0.0209264 |
| TRABD2B | TraB domain containing 2B | 0.0208483 |
| ATXN1 | ataxin 1 | 0.020733 |
| DENND1A | DENN/MADD domain containing 1A | 0.0207046 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0205471 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0204393 |
| OPTN | optineurin | 0.0202071 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0202 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0201724 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0199637 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0198722 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.442294 |
| TMSB10 | thymosin beta 10 | -0.138675 |
| PTMA | prothymosin, alpha | -0.123848 |
| MT2A | metallothionein 2A | -0.11693 |
| UBC | ubiquitin C | -0.107107 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0776828 |
| CENPF | centromere protein F, 350/400kDa | -0.0717776 |
| COL3A1 | collagen, type III, alpha 1 | -0.0593617 |
| SMC4 | structural maintenance of chromosomes 4 | -0.057646 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0556968 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0555041 |
| POTEF | POTE ankyrin domain family, member F | -0.0550247 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.052342 |
| RRM2 | ribonucleotide reductase M2 | -0.0510887 |
| COL1A2 | collagen, type I, alpha 2 | -0.048434 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0469362 |
| MKI67 | marker of proliferation Ki-67 | -0.0427566 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.041695 |
| STC1 | stanniocalcin 1 | -0.0415257 |
| S100A6 | S100 calcium binding protein A6 | -0.0414899 |
| COL5A2 | collagen, type V, alpha 2 | -0.0414577 |
| DIAPH3 | diaphanous-related formin 3 | -0.0411052 |
| TPM4 | tropomyosin 4 | -0.0408724 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.040075 |
| FTL | ferritin, light polypeptide | -0.0396101 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.036748 |
| RPLP1 | ribosomal protein, large, P1 | -0.0362447 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.036159 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0354249 |
| LOX | lysyl oxidase | -0.0337627 |
| B2M | beta-2-microglobulin | -0.0326016 |
| FRMD4A | FERM domain containing 4A | -0.0323588 |
| DEK | DEK proto-oncogene | -0.0319236 |
| PKM | pyruvate kinase, muscle | -0.0318392 |
| CD44 | CD44 molecule (Indian blood group) | -0.0309778 |
| TAGLN2 | transgelin 2 | -0.0301812 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0301479 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0301228 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.030032 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0294372 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0289165 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0288699 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0276247 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0275661 |
| LMNA | lamin A/C | -0.0272135 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0269425 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.026727 |
| CBX3 | chromobox homolog 3 | -0.0264894 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0264438 |
| GNAS | GNAS complex locus | -0.0263244 |
| PFN1 | profilin 1 | -0.0262958 |
| SEPTIN7 | septin 7 | -0.0262451 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0257165 |
| TPX2 | TPX2, microtubule-associated | -0.0255727 |
| ANLN | anillin, actin binding protein | -0.0253771 |
| HMGB1 | high mobility group box 1 | -0.0249882 |
| SMIM44 | small integral membrane protein 44 | -0.0248211 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0246978 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0244989 |
| CD99 | CD99 molecule | -0.0243421 |
| SUCNR1 | succinate receptor 1 | -0.0243172 |
| PCBP2 | poly(rC) binding protein 2 | -0.0243106 |
| KPNB1 | karyopherin (importin) beta 1 | -0.024174 |
| ENO1 | enolase 1, (alpha) | -0.0241169 |
| RBM25 | RNA binding motif protein 25 | -0.0238986 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0238592 |
| RPS6 | ribosomal protein S6 | -0.0236117 |
| ASPH | aspartate beta-hydroxylase | -0.023426 |
| RPL23 | ribosomal protein L23 | -0.0233247 |
| SMC3 | structural maintenance of chromosomes 3 | -0.0228117 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0223983 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0221315 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | -0.0220609 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0220503 |
| MYADM | myeloid-associated differentiation marker | -0.0217284 |
| BRCA1 | breast cancer 1, early onset | -0.0216705 |
| TUBA1B | tubulin, alpha 1b | -0.0216356 |
| HMGB2 | high mobility group box 2 | -0.0216287 |
| RPS27A | ribosomal protein S27a | -0.0215238 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0213622 |
| CENPK | centromere protein K | -0.021204 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0211077 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0209121 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0202825 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -0.0202757 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0200599 |
| ZNF207 | zinc finger protein 207 | -0.0200121 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0198964 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.019758 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0197357 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0195891 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0195664 |
| RRM1 | ribonucleotide reductase M1 | -0.0191072 |
| FOSL1 | FOS-like antigen 1 | -0.0190362 |
| RACK1 | receptor for activated C kinase 1 | -0.0190036 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0186466 |
| HELLS | helicase, lymphoid-specific | -0.0186378 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0184793 |
| KIF18B | kinesin family member 18B | -0.0183339 |
| RPS24 | ribosomal protein S24 | -0.018226 |
