| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | palbociclib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the palbociclib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGA2 | high mobility group AT-hook 2 | 0.120607 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0808417 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0720903 |
| INTS6 | integrator complex subunit 6 | 0.0701601 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0682912 |
| ACTG1 | actin gamma 1 | 0.0678053 |
| CCN2 | cellular communication network factor 2 | 0.0655964 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0636203 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.062025 |
| ASPH | aspartate beta-hydroxylase | 0.0561728 |
| EHBP1 | EH domain binding protein 1 | 0.0536831 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0534996 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0525567 |
| PCDH9 | protocadherin 9 | 0.0493532 |
| EGR1 | early growth response 1 | 0.0493419 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0455749 |
| YAP1 | Yes-associated protein 1 | 0.0434127 |
| ADIPOR2 | adiponectin receptor 2 | 0.0414241 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0407068 |
| TPM3 | tropomyosin 3 | 0.0389922 |
| LRRC23 | leucine rich repeat containing 23 | 0.03899 |
| BRD2 | bromodomain containing 2 | 0.0383401 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0366468 |
| JMJD1C | jumonji domain containing 1C | 0.0362091 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0357085 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0351812 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0349085 |
| DENND5A | DENN/MADD domain containing 5A | 0.0348757 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0329413 |
| SERTAD2 | SERTA domain containing 2 | 0.0323237 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.03227 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0319997 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0314271 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0314176 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0313885 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0312526 |
| PDCD6 | programmed cell death 6 | 0.0311285 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0310523 |
| NRXN3 | neurexin 3 | 0.0304659 |
| HLA-A | major histocompatibility complex, class I, A | 0.0301022 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0299609 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0296438 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0289894 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0284045 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0277973 |
| ZNF804A | zinc finger protein 804A | 0.0276146 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.027597 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0273391 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0273082 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0272939 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0271612 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0270024 |
| RBM19 | RNA binding motif protein 19 | 0.0269839 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0269664 |
| SETX | senataxin | 0.0269445 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | 0.0268466 |
| ZNF638 | zinc finger protein 638 | 0.0268048 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.0267091 |
| TGM2 | transglutaminase 2 | 0.0256498 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | 0.0252786 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0250049 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0247106 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0245515 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.0242878 |
| INTS4 | integrator complex subunit 4 | 0.023961 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0238227 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0237757 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0237575 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0236837 |
| MCL1 | myeloid cell leukemia 1 | 0.0234312 |
| NABP1 | nucleic acid binding protein 1 | 0.0232381 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0231074 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0230355 |
| HDAC9 | histone deacetylase 9 | 0.0229192 |
| HOMER1 | homer scaffolding protein 1 | 0.0228361 |
| EZR | ezrin | 0.0227804 |
| PRKCE | protein kinase C, epsilon | 0.0225529 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.022488 |
| GOLGB1 | golgin B1 | 0.0224091 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0223635 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0222542 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0220927 |
| POTEF | POTE ankyrin domain family, member F | 0.0220714 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0220293 |
| CALR | calreticulin | 0.0220027 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0219987 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0217908 |
| MAGEA4 | melanoma antigen family A4 | 0.021652 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0216046 |
| JUN | jun proto-oncogene | 0.0215226 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0214936 |
| GSE1 | Gse1 coiled-coil protein | 0.0213256 |
| FAT1 | FAT atypical cadherin 1 | 0.0212308 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.021035 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0208342 |
| DUSP16 | dual specificity phosphatase 16 | 0.0206239 |
| EPHA5 | EPH receptor A5 | 0.0205997 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0205334 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0205312 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0205185 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0924591 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0903801 |
| VIM | vimentin | -0.0819287 |
| MKI67 | marker of proliferation Ki-67 | -0.0736409 |
| AREG | amphiregulin | -0.073579 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0702326 |
| ECT2 | epithelial cell transforming 2 | -0.0685795 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0602821 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0590228 |
| CENPF | centromere protein F, 350/400kDa | -0.0581603 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0567552 |
| XPO1 | exportin 1 | -0.053974 |
| PTMA | prothymosin, alpha | -0.0532828 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.052404 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0519232 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0514051 |
| CLDN1 | claudin 1 | -0.0472777 |
| TMEM123 | transmembrane protein 123 | -0.0464632 |
| KIF5B | kinesin family member 5B | -0.0463957 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0461211 |
| TPX2 | TPX2, microtubule-associated | -0.0452148 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0449489 |
| H1-0 | H1.0 linker histone | -0.0443374 |
| YBX3 | Y box binding protein 3 | -0.0441449 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0434071 |
| DIAPH3 | diaphanous-related formin 3 | -0.0423082 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0413099 |
| LMO7 | LIM domain 7 | -0.0413047 |
| MIS18BP1 | MIS18 binding protein 1 | -0.04004 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0400243 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.039691 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0383483 |
| KIF18B | kinesin family member 18B | -0.0379802 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0375824 |
| NDC80 | NDC80 kinetochore complex component | -0.0368084 |
| CENPE | centromere protein E, 312kDa | -0.0360097 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0358177 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0356049 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0336596 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0328407 |
| ANXA1 | annexin A1 | -0.0328332 |
| NLGN1 | neuroligin 1 | -0.0327178 |
| NEK7 | NIMA-related kinase 7 | -0.0325418 |
| NF1 | neurofibromin 1 | -0.0324016 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0323892 |
| PRR11 | proline rich 11 | -0.0323097 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.031802 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0314265 |
| STIL | SCL/TAL1 interrupting locus | -0.031319 |
| CEP192 | centrosomal protein 192kDa | -0.0312776 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0308667 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0307139 |
| CDCA2 | cell division cycle associated 2 | -0.0306454 |
| RPS24 | ribosomal protein S24 | -0.0303645 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0300705 |
| RBM39 | RNA binding motif protein 39 | -0.030049 |
| OXR1 | oxidation resistance 1 | -0.029922 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0296858 |
| ZNF217 | zinc finger protein 217 | -0.0296379 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0294264 |
| CBX3 | chromobox homolog 3 | -0.0292815 |
| HMGB2 | high mobility group box 2 | -0.0291656 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0291332 |
| TNPO1 | transportin 1 | -0.0287457 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0287287 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0283927 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0282355 |
| MMP12 | matrix metallopeptidase 12 | -0.0280566 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0279464 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0278449 |
| HMGA1 | high mobility group AT-hook 1 | -0.0277607 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0274666 |
| ANLN | anillin, actin binding protein | -0.027419 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0273955 |
| RPLP1 | ribosomal protein, large, P1 | -0.0273805 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0272477 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0270238 |
| TMSB10 | thymosin beta 10 | -0.0266117 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0264551 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0264208 |
| KIF4A | kinesin family member 4A | -0.0263499 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0262581 |
| TUBB | tubulin, beta class I | -0.0261353 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0260441 |
| R3HDM1 | R3H domain containing 1 | -0.0258497 |
| KLF6 | Kruppel-like factor 6 | -0.0258125 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0254886 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0251872 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0251756 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0250097 |
| THOC1 | THO complex 1 | -0.0248433 |
| RPL12 | ribosomal protein L12 | -0.02484 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.0247334 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.024688 |
| MATR3 | matrin 3 | -0.0245453 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0244321 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0242817 |
| DST | dystonin | -0.0242729 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0241613 |
| SGO2 | shugoshin 2 | -0.0241462 |
