palbociclib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description palbociclib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the palbociclib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.255732
NDRG1 N-myc downstream regulated 1 0.189636
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.180985
FN1 fibronectin 1 0.17633
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.124411
FNDC3B fibronectin type III domain containing 3B 0.120808
IGFBP3 insulin-like growth factor binding protein 3 0.109313
TRIO trio Rho guanine nucleotide exchange factor 0.107242
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.104591
CDH13 cadherin 13 0.0986928
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0827136
CADM1 cell adhesion molecule 1 0.0810144
PLEC plectin 0.0766738
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0766168
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0719091
JARID2 jumonji, AT rich interactive domain 2 0.0696805
EXT1 exostosin glycosyltransferase 1 0.0672481
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0652959
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0613413
MYH9 myosin, heavy chain 9, non-muscle 0.0579888
GOLGB1 golgin B1 0.0539046
CD44 CD44 molecule (Indian blood group) 0.0537212
VEGFA vascular endothelial growth factor A 0.0521636
PTK2 protein tyrosine kinase 2 0.0510973
COL5A1 collagen, type V, alpha 1 0.0472142
RUNX1 runt-related transcription factor 1 0.0462795
LOXL2 lysyl oxidase-like 2 0.0456892
FBN1 fibrillin 1 0.0456201
GRB10 growth factor receptor-bound protein 10 0.0427366
CAMTA1 calmodulin binding transcription activator 1 0.0425204
NAV2 neuron navigator 2 0.0424053
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0420395
EGFR epidermal growth factor receptor 0.0416306
ZSWIM6 zinc finger, SWIM-type containing 6 0.0412961
SHB Src homology 2 domain containing adaptor protein B 0.040923
SOD2 superoxide dismutase 2, mitochondrial 0.0409011
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0394998
ATXN1 ataxin 1 0.0390215
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0383247
FMNL2 formin-like 2 0.0382528
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0378276
NALF1 NALCN channel auxiliary factor 1 0.0365658
SMAD3 SMAD family member 3 0.0360699
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0357141
PDE10A phosphodiesterase 10A 0.0356797
HSPA8 heat shock 70kDa protein 8 0.0348923
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0342414
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0341181
SQSTM1 sequestosome 1 0.0335886
NAV1 neuron navigator 1 0.0335731
COL7A1 collagen, type VII, alpha 1 0.0333993
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.032686
MLF1 myeloid leukemia factor 1 0.0324429
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0321806
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0321042
FAM107B family with sequence similarity 107, member B 0.0319563
TNS1 tensin 1 0.0318112
MACF1 microtubule-actin crosslinking factor 1 0.03134
HIPK2 homeodomain interacting protein kinase 2 0.0311488
PTPRM protein tyrosine phosphatase, receptor type, M 0.0302448
ASPH aspartate beta-hydroxylase 0.030163
DPYSL2 dihydropyrimidinase-like 2 0.0297747
LPP LIM domain containing preferred translocation partner in lipoma 0.029643
ESYT2 extended synaptotagmin-like protein 2 0.0296083
CXCL8 chemokine (C-X-C motif) ligand 8 0.0293248
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0289089
PDIA5 protein disulfide isomerase family A, member 5 0.0287217
ZMIZ1 zinc finger, MIZ-type containing 1 0.028555
ARRDC3 arrestin domain containing 3 0.0284923
COL6A2 collagen, type VI, alpha 2 0.0282978
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.028017
MYO10 myosin X 0.0276564
RND3 Rho family GTPase 3 0.027415
FAT1 FAT atypical cadherin 1 0.02624
PICALM phosphatidylinositol binding clathrin assembly protein 0.0261711
NOTCH2 notch 2 0.0257188
ADM adrenomedullin 0.0255406
EFNA5 ephrin-A5 0.0254353
PTPRG protein tyrosine phosphatase, receptor type, G 0.025403
AHNAK AHNAK nucleoprotein 0.0251938
PRELID2 PRELI domain containing 2 0.0250786
CMIP c-Maf inducing protein 0.0250109
APP amyloid beta (A4) precursor protein 0.0248014
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0245555
CALU calumenin 0.0244173
DOCK5 dedicator of cytokinesis 5 0.0240438
ANKRD11 ankyrin repeat domain 11 0.0234375
CTBP2 C-terminal binding protein 2 0.0233372
FAM219A family with sequence similarity 219, member A 0.0233358
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0231395
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0230424
ANO6 anoctamin 6 0.0228574
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0227133
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0226661
SLC22A23 solute carrier family 22, member 23 0.0226567
BACE2 beta-site APP-cleaving enzyme 2 0.0225414
NDEL1 nudE neurodevelopment protein 1-like 1 0.0225378
FNIP1 folliculin interacting protein 1 0.0224913
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0224116
LTBP1 latent transforming growth factor beta binding protein 1 0.0222525

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.229001
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.153458
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.148431
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.10236
COL1A1 collagen, type I, alpha 1 -0.0901604
PTMA prothymosin, alpha -0.0677489
TMSB10 thymosin beta 10 -0.0552866
FTL ferritin, light polypeptide -0.0544129
LOX lysyl oxidase -0.0513957
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0472031
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0439723
IER3 immediate early response 3 -0.0401441
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0395801
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0394685
TPM4 tropomyosin 4 -0.0389292
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0378493
COL1A2 collagen, type I, alpha 2 -0.0376221
RPL35A ribosomal protein L35a -0.0372913
RPS8 ribosomal protein S8 -0.0357393
CALD1 caldesmon 1 -0.0338805
TOP2A topoisomerase (DNA) II alpha 170kDa -0.032211
CAVIN1 caveolae associated protein 1 -0.0315875
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0301841
ENO1 enolase 1, (alpha) -0.0296103
S100A9 S100 calcium binding protein A9 -0.0293748
FTH1 ferritin, heavy polypeptide 1 -0.0252112
MT2A metallothionein 2A -0.0247149
RPL8 ribosomal protein L8 -0.0244966
PALLD palladin, cytoskeletal associated protein -0.0242187
S100A6 S100 calcium binding protein A6 -0.0238948
POSTN periostin, osteoblast specific factor -0.0238474
RPS6 ribosomal protein S6 -0.0234549
SEPTIN7 septin 7 -0.0232149
RPLP1 ribosomal protein, large, P1 -0.0231418
ACTG1 actin gamma 1 -0.0231138
IFI6 interferon, alpha-inducible protein 6 -0.0228043
SMC4 structural maintenance of chromosomes 4 -0.0214944
RPL19 ribosomal protein L19 -0.021478
RPS19 ribosomal protein S19 -0.0211055
GNAS GNAS complex locus -0.0210853
B2M beta-2-microglobulin -0.0210691
VCL vinculin -0.0205585
S100A10 S100 calcium binding protein A10 -0.02037
ANXA2 annexin A2 -0.0202592
TM4SF1 transmembrane 4 L six family member 1 -0.0201373
RPL12 ribosomal protein L12 -0.0200698
PFN1 profilin 1 -0.0200189
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0197967
WSB1 WD repeat and SOCS box containing 1 -0.0193845
HMGA1 high mobility group AT-hook 1 -0.0190327
CENPF centromere protein F, 350/400kDa -0.019029
RACK1 receptor for activated C kinase 1 -0.0189057
RPL36 ribosomal protein L36 -0.0188557
F3 coagulation factor III (thromboplastin, tissue factor) -0.0186431
POTEF POTE ankyrin domain family, member F -0.0185702
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0182724
RAD21 RAD21 homolog (S. pombe) -0.0180425
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0176179
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0175935
LDHA lactate dehydrogenase A -0.0170991
LMAN1 lectin, mannose-binding, 1 -0.0170779
SQLE squalene epoxidase -0.0170253
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.016891
RPL34 ribosomal protein L34 -0.0168062
RPL5 ribosomal protein L5 -0.0167529
CENPE centromere protein E, 312kDa -0.0167188
DSTN destrin (actin depolymerizing factor) -0.0167143
RPL7 ribosomal protein L7 -0.0166327
THY1 Thy-1 cell surface antigen -0.01657
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0165367
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0164973
TPM2 tropomyosin 2 (beta) -0.0160916
MKI67 marker of proliferation Ki-67 -0.0160434
WASF2 WAS protein family, member 2 -0.0160405
LIMA1 LIM domain and actin binding 1 -0.0159714
YBX1 Y box binding protein 1 -0.0158035
RPL30 ribosomal protein L30 -0.0157732
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0157681
RPLP2 ribosomal protein, large, P2 -0.0157335
CAV1 caveolin 1, caveolae protein, 22kDa -0.015701
COL3A1 collagen, type III, alpha 1 -0.0155872
FAM162A family with sequence similarity 162, member A -0.015574
IFITM3 interferon induced transmembrane protein 3 -0.015392
RPS14 ribosomal protein S14 -0.0153174
KLF6 Kruppel-like factor 6 -0.0153044
RPS24 ribosomal protein S24 -0.0151848
TKT transketolase -0.0148494
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0148463
ANLN anillin, actin binding protein -0.0147563
TPM1 tropomyosin 1 (alpha) -0.014749
RPS11 ribosomal protein S11 -0.0147247
RPL23 ribosomal protein L23 -0.0146378
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0146095
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0145967
DIAPH3 diaphanous-related formin 3 -0.0145967
RPL28 ribosomal protein L28 -0.0145614
RPS5 ribosomal protein S5 -0.0145246
RPLP0 ribosomal protein, large, P0 -0.0144426
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0143128
TPI1 triosephosphate isomerase 1 -0.0141695