palbociclib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description palbociclib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the palbociclib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.132015
SAMD4A sterile alpha motif domain containing 4A 0.123416
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.119408
ERRFI1 ERBB receptor feedback inhibitor 1 0.115191
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.114919
FNDC3B fibronectin type III domain containing 3B 0.0988619
SVIL supervillin 0.0904874
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0887649
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0806134
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0744295
LRMDA leucine rich melanocyte differentiation associated 0.0719177
ATXN1 ataxin 1 0.0677472
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0654312
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0617428
APOB apolipoprotein B 0.0581934
AFDN afadin, adherens junction formation factor 0.0546848
ELL2 elongation factor, RNA polymerase II, 2 0.0469126
TNS1 tensin 1 0.0442457
FAM107B family with sequence similarity 107, member B 0.0425223
TRIO trio Rho guanine nucleotide exchange factor 0.0422542
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0420011
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0417534
DSPP dentin sialophosphoprotein 0.0393745
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0392276
RUNX1 runt-related transcription factor 1 0.0388839
MBNL2 muscleblind-like splicing regulator 2 0.038755
EXT1 exostosin glycosyltransferase 1 0.0387192
EPAS1 endothelial PAS domain protein 1 0.0386271
MACF1 microtubule-actin crosslinking factor 1 0.0376572
JMJD1C jumonji domain containing 1C 0.0368656
SMAD3 SMAD family member 3 0.0366562
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0362327
C3 complement component 3 0.0357158
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0355378
DTNA dystrobrevin, alpha 0.0349649
KDM3A lysine (K)-specific demethylase 3A 0.0340714
CAMTA1 calmodulin binding transcription activator 1 0.0338991
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.031856
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0317854
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0314589
CRY1 cryptochrome circadian clock 1 0.0311212
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0310009
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0303889
KIAA1217 KIAA1217 0.0299665
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0297882
PEG3 paternally expressed 3 0.0297236
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0294153
DOCK4 dedicator of cytokinesis 4 0.0289982
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0288192
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0279091
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0271421
ZMIZ1 zinc finger, MIZ-type containing 1 0.0260709
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0260684
WWC2 WW and C2 domain containing 2 0.025791
TLE4 transducin-like enhancer of split 4 0.0256462
ATF3 activating transcription factor 3 0.0255445
CCNY cyclin Y 0.0252774
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0250667
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0250457
TBC1D22A TBC1 domain family, member 22A 0.0247371
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0240906
SIK3 SIK family kinase 3 0.0240454
CEMIP2 cell migration inducing hyaluronidase 2 0.0239199
ARHGAP26 Rho GTPase activating protein 26 0.0239153
MYH9 myosin, heavy chain 9, non-muscle 0.0237012
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0236108
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0233386
FAM13A family with sequence similarity 13, member A 0.023157
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0231516
ZFAND3 zinc finger, AN1-type domain 3 0.0229251
SHB Src homology 2 domain containing adaptor protein B 0.0227406
ESYT2 extended synaptotagmin-like protein 2 0.0226762
IGF1R insulin-like growth factor 1 receptor 0.0220864
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0219319
FLNB filamin B, beta 0.0217517
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0215401
MED13L mediator complex subunit 13-like 0.0212635
JAK1 Janus kinase 1 0.0211205
TF transferrin 0.0209526
ADARB1 adenosine deaminase, RNA-specific, B1 0.0208499
PTK2 protein tyrosine kinase 2 0.0207304
PTPRM protein tyrosine phosphatase, receptor type, M 0.0206942
USP6NL USP6 N-terminal like 0.0206832
PDLIM5 PDZ and LIM domain 5 0.0201709
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0201542
ZEB1 zinc finger E-box binding homeobox 1 0.020063
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0200329
SRRM2 serine/arginine repetitive matrix 2 0.0200048
MBNL1 muscleblind-like splicing regulator 1 0.019996
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0198324
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0196773
PRELID2 PRELI domain containing 2 0.0196607
QKI QKI, KH domain containing, RNA binding 0.019602
EFNA1 ephrin-A1 0.0194194
SOS1 son of sevenless homolog 1 (Drosophila) 0.0193204
OGA O-GlcNAcase 0.019293
AHR aryl hydrocarbon receptor 0.0191204
SOD2 superoxide dismutase 2, mitochondrial 0.0190712
HSPA8 heat shock 70kDa protein 8 0.0189363
INSIG2 insulin induced gene 2 0.0189278

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.480104
AKAP12 A kinase (PRKA) anchor protein 12 -0.224299
MT2A metallothionein 2A -0.130105
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.106157
APOA2 apolipoprotein A-II -0.093608
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0829034
SLC38A2 solute carrier family 38, member 2 -0.0575196
HMGA1 high mobility group AT-hook 1 -0.0569197
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0553299
TMSB10 thymosin beta 10 -0.0526225
RPS6 ribosomal protein S6 -0.041999
EHBP1 EH domain binding protein 1 -0.0416509
RPS8 ribosomal protein S8 -0.037066
TPM4 tropomyosin 4 -0.0347937
RPS24 ribosomal protein S24 -0.0339556
RPLP1 ribosomal protein, large, P1 -0.033587
RPS19 ribosomal protein S19 -0.0305803
IGFBP1 insulin-like growth factor binding protein 1 -0.0300036
FTL ferritin, light polypeptide -0.0288897
RPL34 ribosomal protein L34 -0.027764
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0273041
RPL35A ribosomal protein L35a -0.0257695
RPL37A ribosomal protein L37a -0.0243907
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0238621
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0233748
APOE apolipoprotein E -0.0233732
FRMD5 FERM domain containing 5 -0.0228855
RPL5 ribosomal protein L5 -0.0226511
CCL20 chemokine (C-C motif) ligand 20 -0.0225638
RPS14 ribosomal protein S14 -0.0220623
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0214877
RPS29 ribosomal protein S29 -0.0213774
S100A9 S100 calcium binding protein A9 -0.0207111
AHSG alpha-2-HS-glycoprotein -0.020621
PTMA prothymosin, alpha -0.0205074
RPS21 ribosomal protein S21 -0.0197839
RPL31 ribosomal protein L31 -0.0197624
IFITM1 interferon induced transmembrane protein 1 -0.0181462
KRT18 keratin 18, type I -0.0179389
LYZ lysozyme -0.0179218
ETFB electron-transfer-flavoprotein, beta polypeptide -0.0176574
RPLP2 ribosomal protein, large, P2 -0.0174532
ACTG1 actin gamma 1 -0.0171804
RPL12 ribosomal protein L12 -0.0170883
EGR1 early growth response 1 -0.0169545
RPS25 ribosomal protein S25 -0.0168954
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0168237
GNAS GNAS complex locus -0.0166662
B2M beta-2-microglobulin -0.0164243
POTEF POTE ankyrin domain family, member F -0.0163298
RPS13 ribosomal protein S13 -0.0160263
UBXN4 UBX domain protein 4 -0.0160256
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0157877
RPL9 ribosomal protein L9 -0.0156346
FERMT1 fermitin family member 1 -0.0155831
MAML2 mastermind-like 2 (Drosophila) -0.0155363
RPS27A ribosomal protein S27a -0.015475
SOX4 SRY (sex determining region Y)-box 4 -0.0152496
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0152313
SLC38A1 solute carrier family 38, member 1 -0.0148143
RACK1 receptor for activated C kinase 1 -0.0146932
IER3 immediate early response 3 -0.0146843
TMEM123 transmembrane protein 123 -0.0143781
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0142525
ISG15 ISG15 ubiquitin-like modifier -0.0141847
ITGAV integrin, alpha V -0.013954
RPL10A ribosomal protein L10a -0.0138934
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0138815
ACTN1 actinin, alpha 1 -0.0138303
TM4SF1 transmembrane 4 L six family member 1 -0.013774
RPL36A ribosomal protein L36a -0.0137264
HMGA2 high mobility group AT-hook 2 -0.013702
PFN1 profilin 1 -0.0136153
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0135901
PLIN2 perilipin 2 -0.0135594
KRT19 keratin 19, type I -0.0135573
NPAS2 neuronal PAS domain protein 2 -0.0134329
PKM pyruvate kinase, muscle -0.0133681
PERP PERP, TP53 apoptosis effector -0.0133448
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0130175
S100A6 S100 calcium binding protein A6 -0.0129768
GDF15 growth differentiation factor 15 -0.01267
IGFBP3 insulin-like growth factor binding protein 3 -0.0125863
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0125214
RPS5 ribosomal protein S5 -0.0123771
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0123415
RPL23 ribosomal protein L23 -0.012334
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0122868
RPL7 ribosomal protein L7 -0.0122471
RPS16 ribosomal protein S16 -0.0121924
PDGFB platelet-derived growth factor beta polypeptide -0.0121616
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.012001
MX2 MX dynamin-like GTPase 2 -0.0117558
GLRX glutaredoxin (thioltransferase) -0.0116418
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0116031
RPL19 ribosomal protein L19 -0.011514
VCAN versican -0.0114404
NHSL1 NHS-like 1 -0.0114127
RPL8 ribosomal protein L8 -0.0113536
IFI6 interferon, alpha-inducible protein 6 -0.0112666