palbociclib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description palbociclib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the palbociclib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MTSS1 metastasis suppressor 1 0.207517
LMO7 LIM domain 7 0.141179
MYOF myoferlin 0.125057
TRIO trio Rho guanine nucleotide exchange factor 0.121112
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.10994
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0998757
NDRG1 N-myc downstream regulated 1 0.0895391
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0869956
MEF2A myocyte enhancer factor 2A 0.0868781
CD44 CD44 molecule (Indian blood group) 0.0821179
RAI14 retinoic acid induced 14 0.0766545
NAV2 neuron navigator 2 0.0755802
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0737698
PODXL podocalyxin-like 0.0729663
PDE4D phosphodiesterase 4D, cAMP-specific 0.0723197
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0714512
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0705789
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0694102
ESYT2 extended synaptotagmin-like protein 2 0.0692759
SLC35F3 solute carrier family 35, member F3 0.0657343
GRB10 growth factor receptor-bound protein 10 0.0646135
MBNL2 muscleblind-like splicing regulator 2 0.0635717
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0618703
PTK2 protein tyrosine kinase 2 0.0618542
PLEC plectin 0.0613741
MACF1 microtubule-actin crosslinking factor 1 0.0595713
ANXA1 annexin A1 0.0582237
DOK5 docking protein 5 0.057919
SMAD3 SMAD family member 3 0.0551758
RICTOR RPTOR independent companion of MTOR, complex 2 0.05473
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0538434
MBNL1 muscleblind-like splicing regulator 1 0.0488243
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0476841
JMJD1C jumonji domain containing 1C 0.0468142
EMP1 epithelial membrane protein 1 0.0450143
AKAP13 A kinase (PRKA) anchor protein 13 0.0433868
PSD3 pleckstrin and Sec7 domain containing 3 0.0432879
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0414995
ABI3BP ABI family, member 3 (NESH) binding protein 0.0409069
BLCAP bladder cancer associated protein 0.0399679
FNDC3B fibronectin type III domain containing 3B 0.0399007
AHNAK AHNAK nucleoprotein 0.0398927
NRIP1 nuclear receptor interacting protein 1 0.0397848
KIAA1217 KIAA1217 0.0389075
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0385786
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.037525
TGM2 transglutaminase 2 0.0366085
SULF2 sulfatase 2 0.0364552
FNIP1 folliculin interacting protein 1 0.0360948
SH3PXD2A SH3 and PX domains 2A 0.0353454
KLF5 Kruppel-like factor 5 (intestinal) 0.0347384
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.0340067
RABGAP1L RAB GTPase activating protein 1-like 0.0338345
EXT1 exostosin glycosyltransferase 1 0.0338291
BHLHE40 basic helix-loop-helix family, member e40 0.0332581
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0327052
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0323866
EZR ezrin 0.0323361
FAM107B family with sequence similarity 107, member B 0.0321004
ZEB1 zinc finger E-box binding homeobox 1 0.0318759
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0317889
ANO6 anoctamin 6 0.031658
ARRDC3 arrestin domain containing 3 0.031622
PDLIM5 PDZ and LIM domain 5 0.0314825
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0312941
PGK1 phosphoglycerate kinase 1 0.0310568
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0305506
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0304933
PPARG peroxisome proliferator-activated receptor gamma 0.0302103
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0300341
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.029652
CSMD2 CUB and Sushi multiple domains 2 0.0296119
ARHGAP21 Rho GTPase activating protein 21 0.02954
HSPA8 heat shock 70kDa protein 8 0.0294196
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0291654
LYST lysosomal trafficking regulator 0.0285383
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0279753
CDK6 cyclin-dependent kinase 6 0.0279172
RNF217 ring finger protein 217 0.0274291
ANKRD28 ankyrin repeat domain 28 0.0262735
MEGF6 multiple EGF-like-domains 6 0.0262616
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.026224
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0262057
DENND1A DENN/MADD domain containing 1A 0.0259217
ZSWIM6 zinc finger, SWIM-type containing 6 0.0257119
WHRN whirlin 0.025551
HMGA2 high mobility group AT-hook 2 0.0252886
KIF16B kinesin family member 16B 0.0243316
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0242182
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0242105
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.024062
KIAA1671 KIAA1671 0.0236487
TMEM65 transmembrane protein 65 0.0235811
ERRFI1 ERBB receptor feedback inhibitor 1 0.0229278
PICALM phosphatidylinositol binding clathrin assembly protein 0.0228124
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0221942
ATP9A ATPase, class II, type 9A 0.0221727
BACE2 beta-site APP-cleaving enzyme 2 0.0221316
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0221164
CDKN2A cyclin-dependent kinase inhibitor 2A 0.022029

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.125451
CLU clusterin -0.104801
B2M beta-2-microglobulin -0.0942505
POTEF POTE ankyrin domain family, member F -0.06801
MT2A metallothionein 2A -0.0659112
IFITM1 interferon induced transmembrane protein 1 -0.0654697
RPS6 ribosomal protein S6 -0.0571355
IFITM3 interferon induced transmembrane protein 3 -0.0538184
TMSB10 thymosin beta 10 -0.0534913
PTMA prothymosin, alpha -0.0523036
FTL ferritin, light polypeptide -0.051326
RPS21 ribosomal protein S21 -0.0499416
ENO1 enolase 1, (alpha) -0.0459649
S100A10 S100 calcium binding protein A10 -0.0445777
RPS19 ribosomal protein S19 -0.0444179
IFI6 interferon, alpha-inducible protein 6 -0.0436912
RPS8 ribosomal protein S8 -0.0422424
BCL2L1 BCL2-like 1 -0.0409053
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0400066
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0386021
SULF1 sulfatase 1 -0.0371034
RPLP2 ribosomal protein, large, P2 -0.0367426
KRT17 keratin 17, type I -0.0365744
MKI67 marker of proliferation Ki-67 -0.0350656
RPLP1 ribosomal protein, large, P1 -0.0346763
S100A9 S100 calcium binding protein A9 -0.0336303
CENPF centromere protein F, 350/400kDa -0.0328386
HLA-B major histocompatibility complex, class I, B -0.0325702
PLAT plasminogen activator, tissue -0.032015
RPS27 ribosomal protein S27 -0.0308746
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0300866
RPL8 ribosomal protein L8 -0.0300337
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.029753
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0295635
KTN1 kinectin 1 (kinesin receptor) -0.0294382
RPL37 ribosomal protein L37 -0.0288019
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0285981
DIAPH3 diaphanous-related formin 3 -0.0284968
RPL35A ribosomal protein L35a -0.0281971
RPL31 ribosomal protein L31 -0.0279156
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0277344
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.027534
ANLN anillin, actin binding protein -0.0270917
IFI27 interferon, alpha-inducible protein 27 -0.0270386
S100A6 S100 calcium binding protein A6 -0.0265354
CYB5R3 cytochrome b5 reductase 3 -0.0265274
RPS14 ribosomal protein S14 -0.0263643
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0261157
RPL11 ribosomal protein L11 -0.0260987
S100A11 S100 calcium binding protein A11 -0.0253266
RPS13 ribosomal protein S13 -0.0248643
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0247556
RPS29 ribosomal protein S29 -0.0247506
TPX2 TPX2, microtubule-associated -0.0244958
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0242467
FOSL1 FOS-like antigen 1 -0.0241787
NRG1 neuregulin 1 -0.0241404
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0237183
RPS27A ribosomal protein S27a -0.0222084
GNAS GNAS complex locus -0.0221494
RPL32 ribosomal protein L32 -0.0218642
RPS25 ribosomal protein S25 -0.0218291
RPL12 ribosomal protein L12 -0.0216958
SMC4 structural maintenance of chromosomes 4 -0.0214213
RPS3 ribosomal protein S3 -0.0212335
CNRIP1 cannabinoid receptor interacting protein 1 -0.0209847
RPL35 ribosomal protein L35 -0.0209744
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0209496
RPL28 ribosomal protein L28 -0.0207672
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0207636
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0207147
PFN1 profilin 1 -0.0207053
RACK1 receptor for activated C kinase 1 -0.0206516
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0205402
NEK7 NIMA-related kinase 7 -0.0205119
RPL36 ribosomal protein L36 -0.0204422
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0202205
RPLP0 ribosomal protein, large, P0 -0.02016
ACTG1 actin gamma 1 -0.0200273
RPL37A ribosomal protein L37a -0.0197851
S100A2 S100 calcium binding protein A2 -0.0197781
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0197694
TNS4 tensin 4 -0.0193635
HLA-A major histocompatibility complex, class I, A -0.0193346
IGFBP4 insulin-like growth factor binding protein 4 -0.0189432
TXNRD1 thioredoxin reductase 1 -0.0188858
ITSN1 intersectin 1 (SH3 domain protein) -0.0186919
SPINK5 serine peptidase inhibitor, Kazal type 5 -0.018481
RTN4 reticulon 4 -0.0184262
IGFBP6 insulin-like growth factor binding protein 6 -0.0184064
WASF2 WAS protein family, member 2 -0.0182978
RPS23 ribosomal protein S23 -0.0180138
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0179243
PKM pyruvate kinase, muscle -0.0176803
RPS11 ribosomal protein S11 -0.0176521
RPL36A ribosomal protein L36a -0.0172454
EGR1 early growth response 1 -0.0172439
SRSF11 serine/arginine-rich splicing factor 11 -0.0172231
TPM4 tropomyosin 4 -0.017198
SOX7 SRY (sex determining region Y)-box 7 -0.0171556