| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | palbociclib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the palbociclib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.157827 |
| KRT8 | keratin 8, type II | 0.085884 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0826925 |
| NEBL | nebulette | 0.0622664 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0593833 |
| TXNIP | thioredoxin interacting protein | 0.0576685 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0552262 |
| KRT18 | keratin 18, type I | 0.0507936 |
| LMO7 | LIM domain 7 | 0.0501706 |
| VEGFA | vascular endothelial growth factor A | 0.0481266 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0468146 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0437969 |
| FAT1 | FAT atypical cadherin 1 | 0.0420432 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0411099 |
| ATXN1 | ataxin 1 | 0.0382894 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0367488 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0360004 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0358444 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0354676 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0349045 |
| CADPS | Ca++-dependent secretion activator | 0.0345945 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0327428 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0319744 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0318592 |
| WHRN | whirlin | 0.0316814 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0304147 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0302345 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0300232 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.0290706 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0289648 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0288597 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.028682 |
| MUC13 | mucin 13, cell surface associated | 0.0284588 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0284166 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0277187 |
| RNF145 | ring finger protein 145 | 0.0273738 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0269341 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0265921 |
| EZR | ezrin | 0.0259014 |
| CALR | calreticulin | 0.0258783 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0255521 |
| MYO5B | myosin VB | 0.0253094 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0248733 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0245053 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0243156 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0235839 |
| PLEC | plectin | 0.0235331 |
| TRIM2 | tripartite motif containing 2 | 0.0234611 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0229947 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0229617 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0227628 |
| BRD2 | bromodomain containing 2 | 0.0225968 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0225943 |
| PIGR | polymeric immunoglobulin receptor | 0.0225854 |
| PDZD8 | PDZ domain containing 8 | 0.022428 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0221411 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.022041 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0220044 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0219364 |
| USP6NL | USP6 N-terminal like | 0.0217392 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0215289 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0214962 |
| GOLGA4 | golgin A4 | 0.0213498 |
| DNM2 | dynamin 2 | 0.0211944 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0209268 |
| VMP1 | vacuole membrane protein 1 | 0.0208114 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.0206486 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0204972 |
| RPL21 | ribosomal protein L21 | 0.0204813 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0203529 |
| ATF3 | activating transcription factor 3 | 0.020346 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.020303 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0198202 |
| TPM3 | tropomyosin 3 | 0.0197355 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0197228 |
| DHFR | dihydrofolate reductase | 0.0196711 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0195726 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0193569 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0188828 |
| ABHD2 | abhydrolase domain containing 2 | 0.0188687 |
| SIK3 | SIK family kinase 3 | 0.0183193 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0181707 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0181384 |
| RPS12 | ribosomal protein S12 | 0.0180128 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.01791 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0177853 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0177375 |
| SHROOM3 | shroom family member 3 | 0.0177202 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0175603 |
| HYOU1 | hypoxia up-regulated 1 | 0.0173938 |
| RPL3 | ribosomal protein L3 | 0.0173649 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.017354 |
| CASZ1 | castor zinc finger 1 | 0.0173064 |
| EPHB2 | EPH receptor B2 | 0.0172989 |
| PCBP2 | poly(rC) binding protein 2 | 0.0172339 |
| SON | SON DNA binding protein | 0.0172127 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0170396 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0169038 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0166324 |
| MYO1E | myosin IE | 0.0166217 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.327301 |
| NPSR1 | neuropeptide S receptor 1 | -0.22133 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.134014 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0926326 |
| ANXA2 | annexin A2 | -0.0923325 |
| TMSB10 | thymosin beta 10 | -0.0847052 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0757302 |
| TPM4 | tropomyosin 4 | -0.0644216 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0591894 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0546439 |
| FERMT1 | fermitin family member 1 | -0.0541328 |
| S100A6 | S100 calcium binding protein A6 | -0.0523254 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0492607 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0475241 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0473333 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0471718 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0464646 |
| IER3 | immediate early response 3 | -0.0454288 |
| FLNB | filamin B, beta | -0.0451368 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0432121 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.04214 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0416905 |
| EPCAM | epithelial cell adhesion molecule | -0.0404084 |
| ASPH | aspartate beta-hydroxylase | -0.0395861 |
| RPS24 | ribosomal protein S24 | -0.0385392 |
| LAMA4 | laminin, alpha 4 | -0.0383212 |
| RPLP1 | ribosomal protein, large, P1 | -0.0382271 |
| HMGB1 | high mobility group box 1 | -0.0374811 |
| CENPF | centromere protein F, 350/400kDa | -0.0368799 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0366571 |
| TFF1 | trefoil factor 1 | -0.0365638 |
| HMGA1 | high mobility group AT-hook 1 | -0.0352184 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0347297 |
| MUC17 | mucin 17, cell surface associated | -0.0347197 |
| ENO1 | enolase 1, (alpha) | -0.0345826 |
| RNF217 | ring finger protein 217 | -0.034141 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.032092 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0308518 |
| DEK | DEK proto-oncogene | -0.0305321 |
| AHNAK | AHNAK nucleoprotein | -0.0303296 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0301922 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0292096 |
| CALB1 | calbindin 1, 28kDa | -0.029204 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0290464 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0288981 |
| ANLN | anillin, actin binding protein | -0.0281582 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0280402 |
| DIAPH3 | diaphanous-related formin 3 | -0.0277789 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0274606 |
| GNAS | GNAS complex locus | -0.0269465 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0265262 |
| SMC4 | structural maintenance of chromosomes 4 | -0.025741 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0255959 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0255763 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0254334 |
| KIF5B | kinesin family member 5B | -0.0252817 |
| VCL | vinculin | -0.0251679 |
| MKI67 | marker of proliferation Ki-67 | -0.0251311 |
| NRN1 | neuritin 1 | -0.0248667 |
| KLK10 | kallikrein-related peptidase 10 | -0.0244749 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0244336 |
| TMEM123 | transmembrane protein 123 | -0.0242577 |
| HDAC2 | histone deacetylase 2 | -0.0242183 |
| TUBA1B | tubulin, alpha 1b | -0.0241225 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0241135 |
| EHBP1 | EH domain binding protein 1 | -0.0239118 |
| CENPE | centromere protein E, 312kDa | -0.0238631 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0237295 |
| H1-0 | H1.0 linker histone | -0.0236809 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.023402 |
| S100A10 | S100 calcium binding protein A10 | -0.0233296 |
| RAD21 | RAD21 homolog (S. pombe) | -0.022638 |
| RIN2 | Ras and Rab interactor 2 | -0.0218068 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0217846 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0216928 |
| RPL34 | ribosomal protein L34 | -0.0216516 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0215277 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0214567 |
| TUBB | tubulin, beta class I | -0.021411 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0212444 |
| LDHA | lactate dehydrogenase A | -0.021121 |
| ECT2 | epithelial cell transforming 2 | -0.0211107 |
| PRSS3 | protease, serine, 3 | -0.0210698 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0208965 |
| CCND1 | cyclin D1 | -0.0206375 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.020228 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0201847 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | -0.0200786 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0199105 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0197933 |
| LSAMP | limbic system-associated membrane protein | -0.0194964 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0194959 |
| HMGB2 | high mobility group box 2 | -0.0194182 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0193922 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0193775 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0192366 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0191533 |
| FRMD5 | FERM domain containing 5 | -0.0190752 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0188177 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0188137 |
