| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | palbociclib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the palbociclib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.181839 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.113368 |
| RNF213 | ring finger protein 213 | 0.106006 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0624941 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0589905 |
| SMAD3 | SMAD family member 3 | 0.0574145 |
| FAM13A | family with sequence similarity 13, member A | 0.0563926 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0559044 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0558722 |
| HOMER1 | homer scaffolding protein 1 | 0.0503601 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0494782 |
| MYOF | myoferlin | 0.0488179 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0461774 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.045361 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0447391 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0440821 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0425381 |
| RAD51B | RAD51 paralog B | 0.0405159 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0398277 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0385317 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0375217 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.037464 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0356715 |
| IRS2 | insulin receptor substrate 2 | 0.0356061 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0352535 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0345734 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0345456 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0339766 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0334647 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0330789 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0327637 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0325003 |
| INTS6 | integrator complex subunit 6 | 0.032443 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0312859 |
| TUFT1 | tuftelin 1 | 0.030002 |
| PGK1 | phosphoglycerate kinase 1 | 0.0298561 |
| ARRDC3 | arrestin domain containing 3 | 0.0284343 |
| PRDX1 | peroxiredoxin 1 | 0.02727 |
| CTBP2 | C-terminal binding protein 2 | 0.026043 |
| CP | ceruloplasmin (ferroxidase) | 0.0256909 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.025583 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0254043 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0253031 |
| ZNF638 | zinc finger protein 638 | 0.0250025 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0249806 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0243993 |
| JMJD1C | jumonji domain containing 1C | 0.0243843 |
| ATOSA | atos homolog A | 0.0242358 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0239481 |
| DOCK5 | dedicator of cytokinesis 5 | 0.023678 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0236122 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0233443 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0233211 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0229099 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0228085 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0224745 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0214082 |
| FNIP1 | folliculin interacting protein 1 | 0.0214073 |
| GPC6 | glypican 6 | 0.0213964 |
| AHR | aryl hydrocarbon receptor | 0.021262 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0211661 |
| ATF3 | activating transcription factor 3 | 0.0208632 |
| CES1 | carboxylesterase 1 | 0.020545 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.02019 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0200058 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0198126 |
| DSPP | dentin sialophosphoprotein | 0.0197896 |
| KIAA1217 | KIAA1217 | 0.0197518 |
| ANO6 | anoctamin 6 | 0.0197483 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0196963 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 0.019505 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0194858 |
| MAP7 | microtubule-associated protein 7 | 0.0193784 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0191743 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0190987 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0190507 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0189998 |
| AFF1 | AF4/FMR2 family, member 1 | 0.018997 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0186536 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.018594 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.018176 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0180771 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0179508 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | 0.0178556 |
| SP100 | SP100 nuclear antigen | 0.0177074 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0173553 |
| DNASE1 | deoxyribonuclease I | 0.0171725 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0171015 |
| TMEM45B | transmembrane protein 45B | 0.0170669 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0170529 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0168852 |
| GOLGB1 | golgin B1 | 0.0166869 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0165757 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0163221 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0162955 |
| HDLBP | high density lipoprotein binding protein | 0.0162307 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0162174 |
| TC2N | tandem C2 domains, nuclear | 0.0161581 |
| ADAR | adenosine deaminase, RNA-specific | 0.0160286 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0158369 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.236331 |
| TMSB10 | thymosin beta 10 | -0.188203 |
| LAMC2 | laminin, gamma 2 | -0.128012 |
| STC1 | stanniocalcin 1 | -0.0975441 |
| LAMA4 | laminin, alpha 4 | -0.0934495 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0763821 |
| SEC61G | Sec61 gamma subunit | -0.0696876 |
| RPLP1 | ribosomal protein, large, P1 | -0.06879 |
| TXNRD1 | thioredoxin reductase 1 | -0.0685841 |
| PTMA | prothymosin, alpha | -0.0665609 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0589371 |
| S100A10 | S100 calcium binding protein A10 | -0.0572535 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0562088 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0558413 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0537294 |
| OSMR | oncostatin M receptor | -0.0529732 |
| MKI67 | marker of proliferation Ki-67 | -0.0520298 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0520171 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0499359 |
| RPS24 | ribosomal protein S24 | -0.047341 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0464578 |
| ACTG1 | actin gamma 1 | -0.0462836 |
| MT1X | metallothionein 1X | -0.0423481 |
| KRT18 | keratin 18, type I | -0.042201 |
| CDCP1 | CUB domain containing protein 1 | -0.0416608 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0413214 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0406956 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0394937 |
| LAMB3 | laminin, beta 3 | -0.0393804 |
| IER3 | immediate early response 3 | -0.0392338 |
| RPL34 | ribosomal protein L34 | -0.0388925 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0387704 |
| HMGA1 | high mobility group AT-hook 1 | -0.0387695 |
| RPL35A | ribosomal protein L35a | -0.0379442 |
| RPLP0 | ribosomal protein, large, P0 | -0.0378269 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0366884 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0366709 |
| RPS6 | ribosomal protein S6 | -0.0362028 |
| AREG | amphiregulin | -0.0359266 |
| S100A11 | S100 calcium binding protein A11 | -0.0354979 |
| POTEF | POTE ankyrin domain family, member F | -0.0351292 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0350005 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0348774 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0345375 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0345332 |
| RPS25 | ribosomal protein S25 | -0.0342569 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0339895 |
| SCEL | sciellin | -0.033762 |
| PKM | pyruvate kinase, muscle | -0.0330849 |
| RPS3 | ribosomal protein S3 | -0.0324914 |
| S100A6 | S100 calcium binding protein A6 | -0.0320741 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0319206 |
| S100A9 | S100 calcium binding protein A9 | -0.0318796 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0315557 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0310557 |
| TES | testin LIM domain protein | -0.0307831 |
| TPM4 | tropomyosin 4 | -0.0303637 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.030247 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0302118 |
| CSTB | cystatin B (stefin B) | -0.030189 |
| RPL12 | ribosomal protein L12 | -0.0298858 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0292931 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0290838 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0290468 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0289906 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0283215 |
| RPS19 | ribosomal protein S19 | -0.0280721 |
| LDHA | lactate dehydrogenase A | -0.0280055 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.0276646 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0275286 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.027066 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0268343 |
| RTN4 | reticulon 4 | -0.0268034 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0267052 |
| RPS8 | ribosomal protein S8 | -0.0266431 |
| CCNI | cyclin I | -0.0265461 |
| CCND1 | cyclin D1 | -0.0264901 |
| RPS21 | ribosomal protein S21 | -0.0264021 |
| PFN1 | profilin 1 | -0.025737 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0254002 |
| WASF2 | WAS protein family, member 2 | -0.0253511 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0252963 |
| RBM25 | RNA binding motif protein 25 | -0.0252836 |
| FBXO11 | F-box protein 11 | -0.0249294 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0248338 |
| RPL8 | ribosomal protein L8 | -0.0248032 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.024771 |
| FOSL1 | FOS-like antigen 1 | -0.0245202 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0244684 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0244649 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0244165 |
| TOP1 | topoisomerase (DNA) I | -0.0243734 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0241629 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0240191 |
| LMO7 | LIM domain 7 | -0.0239935 |
| FERMT1 | fermitin family member 1 | -0.0238664 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0236405 |
| RPL7 | ribosomal protein L7 | -0.023522 |
| RPL5 | ribosomal protein L5 | -0.0234456 |
| ATF4 | activating transcription factor 4 | -0.0234055 |
