| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | palbociclib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the palbociclib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.182789 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0976978 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0818271 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0804598 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0786417 |
| HLA-B | major histocompatibility complex, class I, B | 0.0756963 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0754002 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0704217 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0626051 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0585945 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0565134 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0543236 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0530329 |
| CMIP | c-Maf inducing protein | 0.0519671 |
| KYNU | kynureninase | 0.0512282 |
| ACTG1 | actin gamma 1 | 0.0505604 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0487451 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0486526 |
| HLA-A | major histocompatibility complex, class I, A | 0.0481535 |
| EGFR | epidermal growth factor receptor | 0.0434846 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0426229 |
| ATXN1 | ataxin 1 | 0.0421986 |
| SVIL | supervillin | 0.0420832 |
| FAM107B | family with sequence similarity 107, member B | 0.0411067 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0375074 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.03554 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0354885 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0354842 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0351469 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0351222 |
| AHNAK | AHNAK nucleoprotein | 0.03494 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.034807 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0342539 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0336215 |
| GLIS3 | GLIS family zinc finger 3 | 0.0332909 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0332407 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0325548 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0321988 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0321743 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0321529 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0321067 |
| GOLGB1 | golgin B1 | 0.0313967 |
| MYO1E | myosin IE | 0.0311182 |
| NDRG1 | N-myc downstream regulated 1 | 0.0298994 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0298006 |
| NNMT | nicotinamide N-methyltransferase | 0.0297868 |
| FLNB | filamin B, beta | 0.0297063 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0295628 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0294279 |
| NEBL | nebulette | 0.0294187 |
| HLA-C | major histocompatibility complex, class I, C | 0.0293726 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0291756 |
| HLA-E | major histocompatibility complex, class I, E | 0.0274794 |
| MYOF | myoferlin | 0.026975 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0268441 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0267781 |
| SMAD3 | SMAD family member 3 | 0.02646 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0263146 |
| FGA | fibrinogen alpha chain | 0.0262493 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0257172 |
| NTN4 | netrin 4 | 0.0257061 |
| OSMR | oncostatin M receptor | 0.025377 |
| ASPH | aspartate beta-hydroxylase | 0.0250996 |
| CYTH1 | cytohesin 1 | 0.0242952 |
| RNF213 | ring finger protein 213 | 0.0242631 |
| EXOC6B | exocyst complex component 6B | 0.0242099 |
| PLEC | plectin | 0.0237496 |
| CTBP2 | C-terminal binding protein 2 | 0.0235479 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0233337 |
| FMNL2 | formin-like 2 | 0.0233109 |
| CUX1 | cut-like homeobox 1 | 0.0231367 |
| EFNA5 | ephrin-A5 | 0.0229349 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0229297 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0228518 |
| PDE10A | phosphodiesterase 10A | 0.0227733 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0226129 |
| KIAA0319 | KIAA0319 | 0.0224684 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0222971 |
| DST | dystonin | 0.022164 |
| INTS6 | integrator complex subunit 6 | 0.02192 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0217855 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0217507 |
| VCL | vinculin | 0.0216421 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.021617 |
| FLNA | filamin A, alpha | 0.0215392 |
| ZFHX3 | zinc finger homeobox 3 | 0.0214872 |
| TPM1 | tropomyosin 1 (alpha) | 0.0213808 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0210593 |
| EFNA1 | ephrin-A1 | 0.0210259 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0208669 |
| PYGL | phosphorylase, glycogen, liver | 0.020667 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0206255 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0201209 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0200521 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0198882 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0197968 |
| TNS3 | tensin 3 | 0.0197005 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0194552 |
| LOXL2 | lysyl oxidase-like 2 | 0.0193698 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0192801 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.320233 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.289358 |
| TMSB10 | thymosin beta 10 | -0.144623 |
| FTL | ferritin, light polypeptide | -0.132042 |
| VIM | vimentin | -0.131824 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.12408 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.106818 |
| TXNRD1 | thioredoxin reductase 1 | -0.0928661 |
| PTMA | prothymosin, alpha | -0.0895194 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0781736 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0697754 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0637451 |
| RTN4 | reticulon 4 | -0.0598028 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0547874 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0547014 |
| PFN1 | profilin 1 | -0.0526131 |
| POTEF | POTE ankyrin domain family, member F | -0.0501866 |
| HMGA1 | high mobility group AT-hook 1 | -0.05007 |
| PFDN2 | prefoldin subunit 2 | -0.0466539 |
| YBX1 | Y box binding protein 1 | -0.0464283 |
| RPLP1 | ribosomal protein, large, P1 | -0.0417783 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0403613 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0401484 |
| WDR43 | WD repeat domain 43 | -0.0396784 |
| IGF2 | insulin-like growth factor 2 | -0.0387593 |
| RPLP0 | ribosomal protein, large, P0 | -0.0381803 |
| RBM25 | RNA binding motif protein 25 | -0.037808 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0372035 |
| NOP58 | NOP58 ribonucleoprotein | -0.0369446 |
| RPL19 | ribosomal protein L19 | -0.0364017 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0362995 |
| USP3 | ubiquitin specific peptidase 3 | -0.0362358 |
| ZNF207 | zinc finger protein 207 | -0.0351741 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.034731 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0347233 |
| YBX3 | Y box binding protein 3 | -0.0344231 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0343774 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0341641 |
| KIF5B | kinesin family member 5B | -0.0339272 |
| RPL23 | ribosomal protein L23 | -0.0334157 |
| RPS19 | ribosomal protein S19 | -0.0332633 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0328132 |
| RRM2 | ribonucleotide reductase M2 | -0.0323948 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0319843 |
| RBM39 | RNA binding motif protein 39 | -0.0316114 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0315118 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0309899 |
| TMEM123 | transmembrane protein 123 | -0.0307109 |
| TPX2 | TPX2, microtubule-associated | -0.030577 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0303684 |
| CCNL1 | cyclin L1 | -0.0303658 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0303175 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0302301 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0301859 |
| ECT2 | epithelial cell transforming 2 | -0.029498 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0291651 |
| ANLN | anillin, actin binding protein | -0.0288852 |
| HMGB1 | high mobility group box 1 | -0.0286927 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0285584 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0284747 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0284136 |
| RPL7 | ribosomal protein L7 | -0.0283715 |
| RPL36 | ribosomal protein L36 | -0.0283347 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0277504 |
| CYRIB | CYFIP related Rac1 interactor B | -0.027416 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.027134 |
| CHN1 | chimerin 1 | -0.0267643 |
| TUBA1B | tubulin, alpha 1b | -0.0264811 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0261765 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0258722 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0257391 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0256038 |
| NUP58 | nucleoporin 58 | -0.0254574 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0254396 |
| MKI67 | marker of proliferation Ki-67 | -0.0254388 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0253353 |
| CENPF | centromere protein F, 350/400kDa | -0.0252379 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0252014 |
| PKM | pyruvate kinase, muscle | -0.0252 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0250326 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0249891 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0249007 |
| WBP11 | WW domain binding protein 11 | -0.0246968 |
| RHEB | Ras homolog enriched in brain | -0.0246547 |
| SEPTIN7 | septin 7 | -0.0245984 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0245847 |
| ZNF292 | zinc finger protein 292 | -0.0243515 |
| TFG | TRK-fused gene | -0.0242496 |
| MTF2 | metal response element binding transcription factor 2 | -0.0235659 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0233627 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0233132 |
| PCBP2 | poly(rC) binding protein 2 | -0.0232773 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0231694 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0231477 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0230612 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0227599 |
| RPL8 | ribosomal protein L8 | -0.0224708 |
| RPS5 | ribosomal protein S5 | -0.0224661 |
| ERBIN | erbb2 interacting protein | -0.0224121 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0224059 |
