| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | palbociclib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the palbociclib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.162943 |
| KRT17 | keratin 17, type I | 0.156351 |
| KYNU | kynureninase | 0.131939 |
| PKM | pyruvate kinase, muscle | 0.105119 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.10338 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0914778 |
| TXNRD1 | thioredoxin reductase 1 | 0.0798438 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.079314 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0761822 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0740479 |
| NDRG1 | N-myc downstream regulated 1 | 0.0735861 |
| NPTN | neuroplastin | 0.0654173 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0630866 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0630646 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0614958 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.051207 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0506514 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0506373 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0502826 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 0.0498612 |
| LAMB3 | laminin, beta 3 | 0.0485124 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0482922 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0458828 |
| OGA | O-GlcNAcase | 0.0458752 |
| MED13L | mediator complex subunit 13-like | 0.0457661 |
| MXD1 | MAX dimerization protein 1 | 0.0451014 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0449348 |
| SQSTM1 | sequestosome 1 | 0.0447344 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0442628 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0434683 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0425042 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0413493 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0409996 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0407255 |
| RNF145 | ring finger protein 145 | 0.0395692 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0391204 |
| FTL | ferritin, light polypeptide | 0.0388546 |
| EXOC6B | exocyst complex component 6B | 0.0384275 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0380882 |
| FMNL2 | formin-like 2 | 0.0376923 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0373454 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0371166 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0370697 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0368782 |
| FAM13A | family with sequence similarity 13, member A | 0.0352613 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0352598 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0351521 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.034031 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.033698 |
| RPL11 | ribosomal protein L11 | 0.033621 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0336204 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0332965 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0331093 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0323774 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0323181 |
| GNAS | GNAS complex locus | 0.0320846 |
| PARD3 | par-3 family cell polarity regulator | 0.0319928 |
| COLEC11 | collectin sub-family member 11 | 0.0311765 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0311632 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0310767 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0310232 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0303429 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.029815 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0297336 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0296582 |
| MYOF | myoferlin | 0.0294557 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0291188 |
| CALU | calumenin | 0.0289984 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0285341 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0281626 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0281148 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0279399 |
| RPL7A | ribosomal protein L7a | 0.0276972 |
| B2M | beta-2-microglobulin | 0.0273532 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0271228 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0270006 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0267437 |
| STK17A | serine/threonine kinase 17a | 0.02616 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0256403 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0255543 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0254965 |
| RIGI | RNA sensor RIG-I | 0.0251866 |
| ABHD17C | abhydrolase domain containing 17C | 0.0250309 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0249464 |
| TMEM165 | transmembrane protein 165 | 0.0243511 |
| UBC | ubiquitin C | 0.0235716 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0235038 |
| ARRDC3 | arrestin domain containing 3 | 0.0233979 |
| SPAG9 | sperm associated antigen 9 | 0.023397 |
| LAMA4 | laminin, alpha 4 | 0.0232842 |
| IER3 | immediate early response 3 | 0.022912 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0220445 |
| ANXA2 | annexin A2 | 0.0218946 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.02157 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.021568 |
| RPL13A | ribosomal protein L13a | 0.0211092 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0210858 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0210009 |
| TUFT1 | tuftelin 1 | 0.0208644 |
| SMYD3 | SET and MYND domain containing 3 | 0.0206902 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.100071 |
| FN1 | fibronectin 1 | -0.0915771 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0799176 |
| SNX9 | sorting nexin 9 | -0.0588883 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0573238 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0561998 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0561692 |
| ATOSA | atos homolog A | -0.0516655 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0513596 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0509219 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0483771 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0463327 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0455744 |
| LMO7 | LIM domain 7 | -0.0452632 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0451589 |
| RPS21 | ribosomal protein S21 | -0.044906 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0446311 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0434841 |
| INHBA | inhibin, beta A | -0.0425445 |
| USP3 | ubiquitin specific peptidase 3 | -0.0422533 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0420719 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0418801 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0415203 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -0.0406306 |
| EGFR | epidermal growth factor receptor | -0.0395278 |
| POTEF | POTE ankyrin domain family, member F | -0.0383358 |
| RCOR1 | REST corepressor 1 | -0.0381356 |
| ZNF644 | zinc finger protein 644 | -0.0379553 |
| HECTD4 | HECT domain containing E3 ubiquitin protein ligase 4 | -0.0375067 |
| EGR1 | early growth response 1 | -0.0367932 |
| FDPS | farnesyl diphosphate synthase | -0.0367505 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0364751 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0363766 |
| DST | dystonin | -0.0357146 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0355364 |
| TPM3 | tropomyosin 3 | -0.0353104 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.035287 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0350042 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.034341 |
| ATP11A | ATPase, class VI, type 11A | -0.0343282 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0332731 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0328348 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0326991 |
| FOXP1 | forkhead box P1 | -0.03235 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0319849 |
| VCL | vinculin | -0.0318814 |
| CMIP | c-Maf inducing protein | -0.0318761 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0317736 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0315473 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0312109 |
| DNAAF9 | dynein axonemal assembly factor 9 | -0.030824 |
| CD44 | CD44 molecule (Indian blood group) | -0.0306175 |
| MUC16 | mucin 16, cell surface associated | -0.0305522 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.030168 |
| YY1 | YY1 transcription factor | -0.030069 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0296581 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.029566 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0293805 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0293035 |
| NCKAP1 | NCK-associated protein 1 | -0.0291403 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0288854 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | -0.0287221 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.028601 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0285829 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.028485 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0279526 |
| NAV2 | neuron navigator 2 | -0.0278532 |
| HELZ | helicase with zinc finger | -0.0276899 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0276628 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0272517 |
| RIOK3 | RIO kinase 3 | -0.027213 |
| RRBP1 | ribosome binding protein 1 | -0.0267837 |
| CALR | calreticulin | -0.026547 |
| RACK1 | receptor for activated C kinase 1 | -0.0265294 |
| GPC6 | glypican 6 | -0.0265046 |
| JMJD1C | jumonji domain containing 1C | -0.0263867 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0263827 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0262216 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0260065 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0258398 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0257724 |
| RPS6 | ribosomal protein S6 | -0.0256338 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0254848 |
| SLMAP | sarcolemma associated protein | -0.0253703 |
| BPTF | bromodomain PHD finger transcription factor | -0.0252807 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0249676 |
| CD2AP | CD2-associated protein | -0.0247467 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0246947 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0246507 |
| FHIT | fragile histidine triad | -0.0240673 |
| SVIL | supervillin | -0.0239984 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.023889 |
| RPS25 | ribosomal protein S25 | -0.0234091 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0232274 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0230874 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0229829 |
| EMP1 | epithelial membrane protein 1 | -0.0229721 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0227628 |
| PRELID2 | PRELI domain containing 2 | -0.0227032 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0226023 |
