| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | palbociclib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the palbociclib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MCL1 | myeloid cell leukemia 1 | 0.131101 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.119427 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.108838 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0911681 |
| ATXN1 | ataxin 1 | 0.0801075 |
| HLA-B | major histocompatibility complex, class I, B | 0.0770026 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.066136 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0651291 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0647675 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.06269 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0623705 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0599006 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0596709 |
| PRKCE | protein kinase C, epsilon | 0.0594442 |
| GRAMD1B | GRAM domain containing 1B | 0.0581475 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0566424 |
| GOLGB1 | golgin B1 | 0.0565912 |
| PDE10A | phosphodiesterase 10A | 0.0556399 |
| PRELID2 | PRELI domain containing 2 | 0.0535634 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0525704 |
| EXOC4 | exocyst complex component 4 | 0.0522983 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0522777 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0519116 |
| INTS6 | integrator complex subunit 6 | 0.0516054 |
| AEBP2 | AE binding protein 2 | 0.0511053 |
| BRD2 | bromodomain containing 2 | 0.0508134 |
| PLEC | plectin | 0.0479787 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0469245 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0468352 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0462685 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0458836 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.045421 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0449533 |
| YBX3 | Y box binding protein 3 | 0.0448092 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0447645 |
| FMNL2 | formin-like 2 | 0.0430528 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0427637 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.04271 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0423045 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0416981 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0413888 |
| COPA | coatomer protein complex, subunit alpha | 0.0411952 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0409238 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0403181 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0402216 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.040208 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0401665 |
| EXOC6B | exocyst complex component 6B | 0.0391396 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0391388 |
| ADAR | adenosine deaminase, RNA-specific | 0.0385047 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0382805 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0379202 |
| JMJD1C | jumonji domain containing 1C | 0.0373728 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0372567 |
| HOMER1 | homer scaffolding protein 1 | 0.0371582 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0371396 |
| HDAC4 | histone deacetylase 4 | 0.0370567 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0368876 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0367952 |
| SIK3 | SIK family kinase 3 | 0.0366031 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0364051 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0361322 |
| KRT18 | keratin 18, type I | 0.036097 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0353768 |
| ATP11A | ATPase, class VI, type 11A | 0.0353235 |
| INTS3 | integrator complex subunit 3 | 0.0353132 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0349861 |
| CPNE1 | copine I | 0.0346557 |
| VMP1 | vacuole membrane protein 1 | 0.0345738 |
| ANO6 | anoctamin 6 | 0.0344356 |
| WWOX | WW domain containing oxidoreductase | 0.034242 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0336491 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.03355 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0327782 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0327484 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0327467 |
| CTTN | cortactin | 0.0326687 |
| RBM19 | RNA binding motif protein 19 | 0.0324331 |
| RAD51B | RAD51 paralog B | 0.0320594 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0314601 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0311496 |
| PYGL | phosphorylase, glycogen, liver | 0.0307193 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0304077 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0303747 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0297981 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0295519 |
| DENND5B | DENN/MADD domain containing 5B | 0.0291902 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0291575 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0288415 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0287767 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0286077 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0285942 |
| TRIM59 | tripartite motif containing 59 | 0.0282737 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0279872 |
| UBN2 | ubinuclein 2 | 0.0278448 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0277185 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0276106 |
| DST | dystonin | 0.0275722 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0273149 |
| RPS3 | ribosomal protein S3 | 0.027302 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.159131 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.155966 |
| VIM | vimentin | -0.0908748 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0788358 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0756039 |
| PTMA | prothymosin, alpha | -0.0740231 |
| MKI67 | marker of proliferation Ki-67 | -0.0720621 |
| SMC4 | structural maintenance of chromosomes 4 | -0.070662 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0661583 |
| RRM2 | ribonucleotide reductase M2 | -0.0652209 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.057786 |
| RTN4 | reticulon 4 | -0.0559564 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0525848 |
| DIAPH3 | diaphanous-related formin 3 | -0.0523589 |
| CENPF | centromere protein F, 350/400kDa | -0.0470948 |
| PHIP | pleckstrin homology domain interacting protein | -0.0467527 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.045136 |
| DEK | DEK proto-oncogene | -0.0427914 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0414408 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0403717 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0401592 |
| ZFR | zinc finger RNA binding protein | -0.0394486 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0386415 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0377287 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0375828 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0375506 |
| SEPTIN7 | septin 7 | -0.0362971 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0353085 |
| RBM25 | RNA binding motif protein 25 | -0.03445 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0339157 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0336557 |
| MELK | maternal embryonic leucine zipper kinase | -0.0335402 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0335187 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0335058 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0334824 |
| KLF6 | Kruppel-like factor 6 | -0.0331996 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0313437 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0308259 |
| NUP153 | nucleoporin 153kDa | -0.0306284 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0303152 |
| CBX3 | chromobox homolog 3 | -0.0302925 |
| XPO1 | exportin 1 | -0.0301988 |
| RBL1 | retinoblastoma-like 1 | -0.030151 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0300597 |
| TPX2 | TPX2, microtubule-associated | -0.0298702 |
| PFN1 | profilin 1 | -0.0298663 |
| KIF4A | kinesin family member 4A | -0.0294167 |
| TMSB10 | thymosin beta 10 | -0.0293628 |
| TUBA1B | tubulin, alpha 1b | -0.0287422 |
| NUP155 | nucleoporin 155kDa | -0.0286147 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0284515 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0281567 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0281225 |
| ANLN | anillin, actin binding protein | -0.027918 |
| TMPO | thymopoietin | -0.0274754 |
| SGO2 | shugoshin 2 | -0.0274732 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0272245 |
| HELLS | helicase, lymphoid-specific | -0.0270161 |
| RPLP1 | ribosomal protein, large, P1 | -0.0268678 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0267686 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0263369 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0263197 |
| CLSPN | claspin | -0.0262499 |
| CENPE | centromere protein E, 312kDa | -0.0258404 |
| KIF2C | kinesin family member 2C | -0.0258148 |
| HMGA1 | high mobility group AT-hook 1 | -0.025452 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0253902 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0253125 |
| STMN1 | stathmin 1 | -0.025264 |
| MATR3 | matrin 3 | -0.0252099 |
| MT2A | metallothionein 2A | -0.0250794 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0249656 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0248805 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0248195 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0247955 |
| KNTC1 | kinetochore associated 1 | -0.0247721 |
| WDHD1 | WD repeat and HMG-box DNA binding protein 1 | -0.0247232 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0247077 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0246346 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0246318 |
| KNL1 | kinetochore scaffold 1 | -0.0246205 |
| CIP2A | cellular inhibitor of PP2A | -0.0245584 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0244056 |
| TPI1 | triosephosphate isomerase 1 | -0.0243612 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -0.024105 |
| LDHB | lactate dehydrogenase B | -0.0238001 |
| SRP72 | signal recognition particle 72kDa | -0.0236979 |
| RPL5 | ribosomal protein L5 | -0.0236624 |
| CDC27 | cell division cycle 27 | -0.0235915 |
| TOPBP1 | topoisomerase (DNA) II binding protein 1 | -0.0235789 |
| KIF18B | kinesin family member 18B | -0.0234787 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0231209 |
| CCDC88A | coiled-coil domain containing 88A | -0.022923 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0227097 |
| RAI1 | retinoic acid induced 1 | -0.0226823 |
| IMMT | inner membrane protein, mitochondrial | -0.0225808 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0225572 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0223101 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0222693 |
| NDC80 | NDC80 kinetochore complex component | -0.0220568 |
