palbociclib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description palbociclib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the palbociclib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.180153
ACTG1 actin gamma 1 0.131563
FN1 fibronectin 1 0.113256
FNDC3B fibronectin type III domain containing 3B 0.107981
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0898216
FAM13A family with sequence similarity 13, member A 0.0883527
TRIO trio Rho guanine nucleotide exchange factor 0.0849764
HSPA8 heat shock 70kDa protein 8 0.0831569
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0824387
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0822761
EIF1 eukaryotic translation initiation factor 1 0.0754741
MYH9 myosin, heavy chain 9, non-muscle 0.0736959
ELL2 elongation factor, RNA polymerase II, 2 0.0733528
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0728475
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0716681
PLEC plectin 0.0700963
LOC112694756 uncharaterized LOC112694756 0.0651522
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0627168
HLA-B major histocompatibility complex, class I, B 0.0626992
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0599443
APLP2 amyloid beta (A4) precursor-like protein 2 0.0592139
SQSTM1 sequestosome 1 0.0582511
GRB10 growth factor receptor-bound protein 10 0.0564949
PTK2 protein tyrosine kinase 2 0.0563224
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0563072
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0556801
PPARD peroxisome proliferator-activated receptor delta 0.0541257
TSC22D2 TSC22 domain family, member 2 0.0522054
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0520512
EEF2 eukaryotic translation elongation factor 2 0.0509683
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0507543
TUFT1 tuftelin 1 0.0505731
BRD2 bromodomain containing 2 0.0467773
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0466737
ZSWIM6 zinc finger, SWIM-type containing 6 0.0451602
PGK1 phosphoglycerate kinase 1 0.0442914
FLNB filamin B, beta 0.0440478
DSCAM Down syndrome cell adhesion molecule 0.0435477
RPL4 ribosomal protein L4 0.0416183
CANX calnexin 0.0413785
COPA coatomer protein complex, subunit alpha 0.0394828
RPS12 ribosomal protein S12 0.0389263
HLA-A major histocompatibility complex, class I, A 0.0385877
VEGFA vascular endothelial growth factor A 0.038192
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.037759
EZR ezrin 0.0377044
ADAR adenosine deaminase, RNA-specific 0.0370237
SMAD3 SMAD family member 3 0.0367084
TPM3 tropomyosin 3 0.0364842
ATF3 activating transcription factor 3 0.0363499
APP amyloid beta (A4) precursor protein 0.0363493
USP9X ubiquitin specific peptidase 9, X-linked 0.0363288
ARRDC3 arrestin domain containing 3 0.0362336
PRRC2C proline-rich coiled-coil 2C 0.0362016
SAMD4A sterile alpha motif domain containing 4A 0.0354031
TXNIP thioredoxin interacting protein 0.0353303
MCL1 myeloid cell leukemia 1 0.0346125
LAMC2 laminin, gamma 2 0.0344059
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.034312
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0342653
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0339927
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0334531
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0326091
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0321522
DUSP10 dual specificity phosphatase 10 0.0320064
KRT8 keratin 8, type II 0.0319518
ZFAND3 zinc finger, AN1-type domain 3 0.0317481
CTBP2 C-terminal binding protein 2 0.0315942
RPL11 ribosomal protein L11 0.0315801
CD109 CD109 molecule 0.031533
EGR1 early growth response 1 0.0314935
TENT2 terminal nucleotidyltransferase 2 0.031449
MYO5B myosin VB 0.0310382
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.031024
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0309078
ZNF292 zinc finger protein 292 0.0308117
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0308019
SGMS2 sphingomyelin synthase 2 0.0303736
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0301516
TPD52 tumor protein D52 0.0300434
KLHL24 kelch-like family member 24 0.0297755
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0297256
RNF213 ring finger protein 213 0.029371
NPTN neuroplastin 0.0292974
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0292947
KIAA1217 KIAA1217 0.029282
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0292498
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0290932
UGDH UDP-glucose 6-dehydrogenase 0.0289383
RPS3 ribosomal protein S3 0.0288538
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0287995
RPS20 ribosomal protein S20 0.0286563
FHIT fragile histidine triad 0.0286
MYO10 myosin X 0.0283037
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0281031
DTNA dystrobrevin, alpha 0.0279184
HELZ helicase with zinc finger 0.0277213
SRRM2 serine/arginine repetitive matrix 2 0.0276863
CTSB cathepsin B 0.0272957
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0272008

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.132059
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0828603
FTL ferritin, light polypeptide -0.0773247
ASPH aspartate beta-hydroxylase -0.0730567
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0597783
CCND1 cyclin D1 -0.0561036
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0550421
HMGA1 high mobility group AT-hook 1 -0.0528276
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0437088
S100A10 S100 calcium binding protein A10 -0.0427903
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0387079
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0353838
TMSB10 thymosin beta 10 -0.0327503
SOX4 SRY (sex determining region Y)-box 4 -0.0311186
MT2A metallothionein 2A -0.0305766
S100A6 S100 calcium binding protein A6 -0.0304476
F3 coagulation factor III (thromboplastin, tissue factor) -0.0301719
SMC4 structural maintenance of chromosomes 4 -0.0298246
AREG amphiregulin -0.0296608
TPM4 tropomyosin 4 -0.0291574
RPLP1 ribosomal protein, large, P1 -0.0254044
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0251059
ANLN anillin, actin binding protein -0.0247444
HMGB1 high mobility group box 1 -0.0241853
GNAS GNAS complex locus -0.0237853
VIM vimentin -0.0229094
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0228572
MKI67 marker of proliferation Ki-67 -0.0227925
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0215346
TUBA1B tubulin, alpha 1b -0.0211999
HMGB2 high mobility group box 2 -0.0206258
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0205627
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0203285
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0203065
RAD21 RAD21 homolog (S. pombe) -0.0201167
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0197927
HMGA2 high mobility group AT-hook 2 -0.019706
S100A11 S100 calcium binding protein A11 -0.0192765
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.018834
TMEM123 transmembrane protein 123 -0.0186401
POTEF POTE ankyrin domain family, member F -0.0185532
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0175944
FAM3C family with sequence similarity 3, member C -0.0172753
IER3 immediate early response 3 -0.0167738
SACK1A scaffolding CK1 anchoring protein A -0.0165516
ARHGAP5 Rho GTPase activating protein 5 -0.0165232
FOSL1 FOS-like antigen 1 -0.016516
PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.0161743
ANTXR2 anthrax toxin receptor 2 -0.0160379
CBX3 chromobox homolog 3 -0.015649
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0153009
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0152869
TM4SF1 transmembrane 4 L six family member 1 -0.0149668
ZNF207 zinc finger protein 207 -0.0148883
TPX2 TPX2, microtubule-associated -0.0148266
LMO7 LIM domain 7 -0.0144699
ZNF217 zinc finger protein 217 -0.0143539
DEK DEK proto-oncogene -0.0143347
DIAPH3 diaphanous-related formin 3 -0.0138082
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0135535
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0132524
MAML2 mastermind-like 2 (Drosophila) -0.0132462
RRBP1 ribosome binding protein 1 -0.0129953
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0129743
ARHGAP29 Rho GTPase activating protein 29 -0.0129662
NT5C2 5'-nucleotidase, cytosolic II -0.0129328
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0125207
MIS18BP1 MIS18 binding protein 1 -0.0124786
RASAL2 RAS protein activator like 2 -0.0124352
CHMP2B charged multivesicular body protein 2B -0.0123396
KPNB1 karyopherin (importin) beta 1 -0.0123032
SEPTIN7 septin 7 -0.0122643
ITCH itchy E3 ubiquitin protein ligase -0.0122176
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0122059
LMAN1 lectin, mannose-binding, 1 -0.0120491
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0120261
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.011947
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.011863
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0118286
LY6E lymphocyte antigen 6 complex, locus E -0.0117998
KLF6 Kruppel-like factor 6 -0.0117667
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0117406
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0115603
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0115287
CENPE centromere protein E, 312kDa -0.0115134
AK1 adenylate kinase 1 -0.0114965
EHBP1 EH domain binding protein 1 -0.0114805
ITGA1 integrin, alpha 1 -0.0114743
EREG epiregulin -0.0114363
RAI14 retinoic acid induced 14 -0.011374
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0112123
CDK1 cyclin-dependent kinase 1 -0.0112064
TUBB tubulin, beta class I -0.0111279
FAM162A family with sequence similarity 162, member A -0.0110019
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0109823
TTLL11 tubulin tyrosine ligase-like family member 11 -0.0109681
VDAC1 voltage-dependent anion channel 1 -0.0108517
CENPF centromere protein F, 350/400kDa -0.0108377
CAVIN1 caveolae associated protein 1 -0.0107885
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0107366