| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | palbociclib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the palbociclib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.115768 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.093257 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0927237 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0730805 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0645597 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0613874 |
| AUTS2 | autism susceptibility candidate 2 | 0.0610796 |
| MCL1 | myeloid cell leukemia 1 | 0.0605668 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0563218 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0534545 |
| CTBP2 | C-terminal binding protein 2 | 0.0522059 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0516369 |
| CDH13 | cadherin 13 | 0.0506672 |
| SQSTM1 | sequestosome 1 | 0.0496985 |
| PRELID2 | PRELI domain containing 2 | 0.0494445 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0488185 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0481971 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0461282 |
| EZR | ezrin | 0.0455166 |
| NCOR2 | nuclear receptor corepressor 2 | 0.04473 |
| DENND1A | DENN/MADD domain containing 1A | 0.0442348 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0434161 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0427658 |
| XYLT1 | xylosyltransferase I | 0.0422979 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0417471 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0412977 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0411675 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0407651 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0402982 |
| MAP7 | microtubule-associated protein 7 | 0.0394175 |
| NDRG1 | N-myc downstream regulated 1 | 0.0375448 |
| RPS6 | ribosomal protein S6 | 0.036909 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0366946 |
| PGK1 | phosphoglycerate kinase 1 | 0.0358177 |
| FAM107B | family with sequence similarity 107, member B | 0.0354678 |
| LSAMP | limbic system-associated membrane protein | 0.0348216 |
| TENM2 | teneurin transmembrane protein 2 | 0.0346879 |
| HDAC4 | histone deacetylase 4 | 0.0340509 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.034021 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.03183 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0317304 |
| FNIP1 | folliculin interacting protein 1 | 0.0316475 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0315005 |
| HLA-A | major histocompatibility complex, class I, A | 0.0310953 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0310419 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0309362 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0306057 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0300763 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0298791 |
| INTS6 | integrator complex subunit 6 | 0.0298307 |
| RPS12 | ribosomal protein S12 | 0.0298181 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.0297609 |
| CHL1 | cell adhesion molecule L1-like | 0.0295071 |
| SMAD2 | SMAD family member 2 | 0.0294905 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0291549 |
| FMNL2 | formin-like 2 | 0.0284048 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0284011 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0278752 |
| HLA-B | major histocompatibility complex, class I, B | 0.0268418 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0267685 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0265064 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0263243 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0259671 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0256797 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0256381 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0253571 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.025333 |
| SVIL | supervillin | 0.0252644 |
| DNER | delta/notch-like EGF repeat containing | 0.0245302 |
| FAM219A | family with sequence similarity 219, member A | 0.0244189 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0243987 |
| KRT19 | keratin 19, type I | 0.0243833 |
| ATXN1 | ataxin 1 | 0.0243317 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0240522 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0237902 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.0233882 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0233187 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.023274 |
| DST | dystonin | 0.0230219 |
| RPL7A | ribosomal protein L7a | 0.0229431 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0228979 |
| RAD51B | RAD51 paralog B | 0.0228053 |
| NRXN3 | neurexin 3 | 0.0227993 |
| ATF3 | activating transcription factor 3 | 0.0226643 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0225699 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0225561 |
| PKM | pyruvate kinase, muscle | 0.0224739 |
| RPL4 | ribosomal protein L4 | 0.0224636 |
| GLRX | glutaredoxin (thioltransferase) | 0.0223223 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0222706 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0221339 |
| NBEAL1 | neurobeachin-like 1 | 0.0221282 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.022004 |
| TPM3 | tropomyosin 3 | 0.0219666 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.021888 |
| RPL37A | ribosomal protein L37a | 0.0217335 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.0214188 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0213413 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0213102 |
| OXSR1 | oxidative stress responsive 1 | 0.0212759 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.170181 |
| GDA | guanine deaminase | -0.16332 |
| TXNRD1 | thioredoxin reductase 1 | -0.14046 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.105531 |
| ASPH | aspartate beta-hydroxylase | -0.103621 |
| SMYD3 | SET and MYND domain containing 3 | -0.0958723 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0931722 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0904042 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0869915 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.086046 |
| NRCAM | neuronal cell adhesion molecule | -0.0832965 |
| COL5A2 | collagen, type V, alpha 2 | -0.0832116 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0795321 |
| NEK7 | NIMA-related kinase 7 | -0.0781454 |
| CENPF | centromere protein F, 350/400kDa | -0.073211 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0718102 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0645404 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0635786 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0613223 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0607071 |
| MKI67 | marker of proliferation Ki-67 | -0.0602072 |
| PTMA | prothymosin, alpha | -0.0598005 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0578442 |
| TNPO1 | transportin 1 | -0.05382 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0525639 |
| EFNA5 | ephrin-A5 | -0.051281 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0508288 |
| CTSC | cathepsin C | -0.0502591 |
| ENAH | enabled homolog (Drosophila) | -0.0489708 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0488594 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0484103 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0461466 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0460275 |
| VIM | vimentin | -0.0457707 |
| TMSB10 | thymosin beta 10 | -0.0452201 |
| RTN4 | reticulon 4 | -0.0414308 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0387143 |
| RBM39 | RNA binding motif protein 39 | -0.0383784 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0383324 |
| RTN1 | reticulon 1 | -0.0382759 |
| DIAPH3 | diaphanous-related formin 3 | -0.0379181 |
| VCL | vinculin | -0.0376935 |
| ATAD1 | ATPase family, AAA domain containing 1 | -0.0372564 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0369637 |
| OSMR | oncostatin M receptor | -0.0349202 |
| GNAS | GNAS complex locus | -0.0342883 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0339462 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0338785 |
| PTGR1 | prostaglandin reductase 1 | -0.0333671 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.0333301 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0326491 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0324242 |
| SRGN | serglycin | -0.0306556 |
| PHF20 | PHD finger protein 20 | -0.029848 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.029778 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0295622 |
| LAMB1 | laminin, beta 1 | -0.0293835 |
| ANLN | anillin, actin binding protein | -0.0290929 |
| BMERB1 | bMERB domain containing 1 | -0.0289317 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0289044 |
| NF1 | neurofibromin 1 | -0.0288334 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0282163 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0280849 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0279651 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0279244 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0278748 |
| PALLD | palladin, cytoskeletal associated protein | -0.0275477 |
| PCBP3 | poly(rC) binding protein 3 | -0.0274816 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.027235 |
| CHML | choroideremia-like (Rab escort protein 2) | -0.0271743 |
| KIF14 | kinesin family member 14 | -0.0269706 |
| PRKD3 | protein kinase D3 | -0.0269508 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0268579 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0266481 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0263064 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0260934 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0258262 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0256884 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0255905 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.025557 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0254382 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0254167 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0252961 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.0252487 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.025237 |
| CENPE | centromere protein E, 312kDa | -0.0251758 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0251343 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0248744 |
| PUM2 | pumilio RNA-binding family member 2 | -0.024766 |
| MFF | mitochondrial fission factor | -0.0240695 |
| PHF14 | PHD finger protein 14 | -0.0237187 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0237039 |
| EXO1 | exonuclease 1 | -0.023628 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0236238 |
| EVA1C | eva-1 homolog C (C. elegans) | -0.0234896 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0232644 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0232571 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0231884 |
| RPS24 | ribosomal protein S24 | -0.0230797 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0229798 |
