palbociclib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description palbociclib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

64 genes differentially expressed following the palbociclib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.194603
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.145202
NKD1 naked cuticle homolog 1 (Drosophila) 0.11007
SAMD4A sterile alpha motif domain containing 4A 0.108025
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.104681
LPP LIM domain containing preferred translocation partner in lipoma 0.102644
PDE4D phosphodiesterase 4D, cAMP-specific 0.0947171
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0929686
FNDC3B fibronectin type III domain containing 3B 0.0829916
RAP1B RAP1B, member of RAS oncogene family 0.0784692
INHBA inhibin, beta A 0.0771902
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0719812
FAM13A family with sequence similarity 13, member A 0.0660265
COL6A3 collagen, type VI, alpha 3 0.0646017
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0632048
DSCAM Down syndrome cell adhesion molecule 0.0543265
SLTM SAFB-like, transcription modulator 0.0511424
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0462266
AKAP12 A kinase (PRKA) anchor protein 12 0.0403224
AHNAK AHNAK nucleoprotein 0.0367468
TPT1 tumor protein, translationally-controlled 1 0.0361859
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0360676
MYO1E myosin IE 0.0344201
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0302839
NDRG1 N-myc downstream regulated 1 0.0214174
CD44 CD44 molecule (Indian blood group) 0.0182631
EGFR epidermal growth factor receptor 0.0176942
RPS6 ribosomal protein S6 0.0165023
EXT1 exostosin glycosyltransferase 1 0.0163933
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0151783
FTL ferritin, light polypeptide 0.011973
SMAD3 SMAD family member 3 0.00985565
RPS8 ribosomal protein S8 0.00544569
TRIO trio Rho guanine nucleotide exchange factor 0.00421563

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.280631
UBC ubiquitin C -0.218348
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.206561
ACTN4 actinin, alpha 4 -0.197926
RTN4 reticulon 4 -0.187828
NUP58 nucleoporin 58 -0.16236
VIM vimentin -0.158746
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.127503
RPS3 ribosomal protein S3 -0.127396
ANXA2 annexin A2 -0.123565
FN1 fibronectin 1 -0.0926239
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0840167
STC1 stanniocalcin 1 -0.07159
MT2A metallothionein 2A -0.0632189
RPL23 ribosomal protein L23 -0.0625932
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0601587
DST dystonin -0.0601212
LDHA lactate dehydrogenase A -0.0580092
ASPH aspartate beta-hydroxylase -0.0518548
ZBTB20 zinc finger and BTB domain containing 20 -0.0491722
HMGA2 high mobility group AT-hook 2 -0.0399999
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0351372
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0236958
ZFAND3 zinc finger, AN1-type domain 3 -0.0222169
PGK1 phosphoglycerate kinase 1 -0.0194781
EIF1 eukaryotic translation initiation factor 1 -0.0185254
NAMPT nicotinamide phosphoribosyltransferase -0.0160578
ACTG1 actin gamma 1 -0.0104178
RPL35A ribosomal protein L35a -0.00759863
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.00580333