palbociclib_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description palbociclib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the palbociclib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.110563
TSC22D2 TSC22 domain family, member 2 0.100299
CCN2 cellular communication network factor 2 0.0845172
ZNF292 zinc finger protein 292 0.0709317
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0688918
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0662176
ANKRD33B ankyrin repeat domain 33B 0.0652691
ZFAND3 zinc finger, AN1-type domain 3 0.0644614
TMSB4X thymosin beta 4, X-linked 0.0606396
HDAC9 histone deacetylase 9 0.0521721
EVI5 ecotropic viral integration site 5 0.0515146
PUM1 pumilio RNA-binding family member 1 0.0479837
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0477416
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0470491
RHEB Ras homolog enriched in brain 0.0458573
ZEB2 zinc finger E-box binding homeobox 2 0.0456646
PDIA6 protein disulfide isomerase family A, member 6 0.0444634
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0408659
OSBPL10 oxysterol binding protein-like 10 0.0398162
CDK6 cyclin-dependent kinase 6 0.0398115
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0380602
MYO10 myosin X 0.0377663
GLS2 glutaminase 2 (liver, mitochondrial) 0.037506
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0373388
ADAM9 ADAM metallopeptidase domain 9 0.0371478
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0368993
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0363259
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0346351
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0345735
PCBP2 poly(rC) binding protein 2 0.0337727
NAMPT nicotinamide phosphoribosyltransferase 0.0336695
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0332725
QKI QKI, KH domain containing, RNA binding 0.0327657
TRAK1 trafficking protein, kinesin binding 1 0.0327432
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0327049
PRPF8 pre-mRNA processing factor 8 0.0325832
WDR43 WD repeat domain 43 0.0325002
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0322887
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0315705
RBM33 RNA binding motif protein 33 0.0315009
MEMO1 mediator of cell motility 1 0.0311766
SPAG9 sperm associated antigen 9 0.0301532
APP amyloid beta (A4) precursor protein 0.0301282
MED13L mediator complex subunit 13-like 0.0301085
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0299714
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0297595
GARS1 glycyl-tRNA synthetase 1 0.0294542
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.029222
NONO non-POU domain containing, octamer-binding 0.0292127
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0286874
USP9X ubiquitin specific peptidase 9, X-linked 0.0286672
NTM neurotrimin 0.0286218
PICALM phosphatidylinositol binding clathrin assembly protein 0.0284373
FXR1 fragile X mental retardation, autosomal homolog 1 0.0284111
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.028101
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0279586
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0278655
RASAL2 RAS protein activator like 2 0.027647
ENAH enabled homolog (Drosophila) 0.0276056
TPM3 tropomyosin 3 0.0273813
CPNE8 copine VIII 0.026937
NHSL1 NHS-like 1 0.0267078
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0266343
LAMP2 lysosomal-associated membrane protein 2 0.026595
HDLBP high density lipoprotein binding protein 0.0263475
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0256511
SFPQ splicing factor proline/glutamine-rich 0.0256452
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0256394
WAC WW domain containing adaptor with coiled-coil 0.0253893
RLF rearranged L-myc fusion 0.0252017
RAD23B RAD23 homolog B (S. cerevisiae) 0.0251963
MCL1 myeloid cell leukemia 1 0.0251764
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0250014
CAMTA1 calmodulin binding transcription activator 1 0.0248676
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.024818
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0247322
NCKAP1 NCK-associated protein 1 0.0246938
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0246198
PDIA4 protein disulfide isomerase family A, member 4 0.0245195
TRIO trio Rho guanine nucleotide exchange factor 0.0244429
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0243367
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0242304
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0240814
DSCAM Down syndrome cell adhesion molecule 0.0239554
ANK2 ankyrin 2, neuronal 0.0238323
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0238256
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0238024
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0237996
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0234999
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0233943
CDC73 cell division cycle 73 0.0232638
BNC2 basonuclin 2 0.0232474
FUS FUS RNA binding protein 0.0231478
PRRC2A proline-rich coiled-coil 2A 0.0231446
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.023144
HSPA8 heat shock 70kDa protein 8 0.0231135
MB21D2 Mab-21 domain containing 2 0.0230528
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0227857
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.02272
JUN jun proto-oncogene 0.0226621

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.23087
CDH10 cadherin 10, type 2 (T2-cadherin) -0.147331
COL11A1 collagen, type XI, alpha 1 -0.125019
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.120149
COL5A2 collagen, type V, alpha 2 -0.106141
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.10281
PCDH9 protocadherin 9 -0.0980583
GPC3 glypican 3 -0.0752795
PTMA prothymosin, alpha -0.0749774
GNAS GNAS complex locus -0.0685793
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0672178
ADGRV1 adhesion G protein-coupled receptor V1 -0.062494
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0621223
COL1A2 collagen, type I, alpha 2 -0.0584145
COL3A1 collagen, type III, alpha 1 -0.0551556
LDHA lactate dehydrogenase A -0.0548486
TMSB10 thymosin beta 10 -0.0518886
RPS6 ribosomal protein S6 -0.0464997
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0448847
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0432287
PHIP pleckstrin homology domain interacting protein -0.0428813
MDK midkine (neurite growth-promoting factor 2) -0.0423315
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0411977
CUX1 cut-like homeobox 1 -0.0411266
CADM2 cell adhesion molecule 2 -0.0402863
TNRC6B trinucleotide repeat containing 6B -0.0396597
MED12L mediator complex subunit 12-like -0.0396193
MEIS2 Meis homeobox 2 -0.0386009
NCAM2 neural cell adhesion molecule 2 -0.0383823
MPG N-methylpurine-DNA glycosylase -0.0378079
CEP350 centrosomal protein 350kDa -0.0377779
ENO1 enolase 1, (alpha) -0.0372988
DMD dystrophin -0.0365827
TPT1 tumor protein, translationally-controlled 1 -0.0360819
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0352494
DENND5B DENN/MADD domain containing 5B -0.0352118
RPS13 ribosomal protein S13 -0.0351839
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0350531
FTL ferritin, light polypeptide -0.0346998
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0346114
HDAC2 histone deacetylase 2 -0.0345738
RPS8 ribosomal protein S8 -0.0345451
HSPB1 heat shock 27kDa protein 1 -0.0324535
PRELID2 PRELI domain containing 2 -0.0322356
FN1 fibronectin 1 -0.0318699
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0316709
SIK2 salt-inducible kinase 2 -0.0316169
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0312542
PLPP1 phospholipid phosphatase 1 -0.0309667
RPL35A ribosomal protein L35a -0.0304224
NEBL nebulette -0.0303758
PCLO piccolo presynaptic cytomatrix protein -0.0301842
LRRN3 leucine rich repeat neuronal 3 -0.0301035
FAM177A1 family with sequence similarity 177, member A1 -0.0299399
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.029899
RPL37 ribosomal protein L37 -0.0298854
TUBA1B tubulin, alpha 1b -0.0296426
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.02962
TOX thymocyte selection-associated high mobility group box -0.029224
AKAP12 A kinase (PRKA) anchor protein 12 -0.0291091
AHNAK AHNAK nucleoprotein -0.0286134
MRPS30 mitochondrial ribosomal protein S30 -0.0286024
ANKRD12 ankyrin repeat domain 12 -0.0283075
CHD9 chromodomain helicase DNA binding protein 9 -0.0282034
RPL37A ribosomal protein L37a -0.0279481
S100A10 S100 calcium binding protein A10 -0.0276273
MYADM myeloid-associated differentiation marker -0.0271613
BMPR1A bone morphogenetic protein receptor, type IA -0.0271265
RPL5 ribosomal protein L5 -0.0269769
RACK1 receptor for activated C kinase 1 -0.0268736
S100A9 S100 calcium binding protein A9 -0.0268561
CNRIP1 cannabinoid receptor interacting protein 1 -0.0267426
PDCD5 programmed cell death 5 -0.0266332
NBEAL1 neurobeachin-like 1 -0.0265855
LRRC4C leucine rich repeat containing 4C -0.0264632
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0260675
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0260531
CBX3 chromobox homolog 3 -0.0255885
NRXN1 neurexin 1 -0.0253875
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0253282
RPL19 ribosomal protein L19 -0.0250313
SOX5 SRY (sex determining region Y)-box 5 -0.0247565
FRY furry homolog (Drosophila) -0.0247103
HMCN1 hemicentin 1 -0.0246227
SLC38A2 solute carrier family 38, member 2 -0.0243989
PALLD palladin, cytoskeletal associated protein -0.0243544
SNX6 sorting nexin 6 -0.0242391
FST follistatin -0.0242369
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0242303
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0241811
DCAF7 DDB1 and CUL4 associated factor 7 -0.0240068
DARS1 aspartyl-tRNA synthetase 1 -0.0239529
RPL31 ribosomal protein L31 -0.0239189
TRIM2 tripartite motif containing 2 -0.0239004
RPS15 ribosomal protein S15 -0.0237691
RPS27A ribosomal protein S27a -0.0237453
ZNF609 zinc finger protein 609 -0.0236437
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0234372
HMGB1 high mobility group box 1 -0.0234008
TUT4 terminal uridylyl transferase 4 -0.0233618