palbociclib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description palbociclib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the palbociclib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0702242
AHNAK AHNAK nucleoprotein 0.0657429
ZNF608 zinc finger protein 608 0.0514439
PDGFC platelet derived growth factor C 0.0511504
EZR ezrin 0.0486071
SOX6 SRY (sex determining region Y)-box 6 0.0405463
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0401308
TJP1 tight junction protein 1 0.036994
HDAC9 histone deacetylase 9 0.0366257
SSBP2 single-stranded DNA binding protein 2 0.0344631
BMP2K BMP2 inducible kinase 0.0339183
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0316794
HSPA8 heat shock 70kDa protein 8 0.0312218
ADAM10 ADAM metallopeptidase domain 10 0.0308699
EML4 echinoderm microtubule associated protein like 4 0.0304141
FLNB filamin B, beta 0.0293851
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0287452
GLI2 GLI family zinc finger 2 0.028661
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0282156
MINDY2 MINDY lysine 48 deubiquitinase 2 0.025941
NCKAP1 NCK-associated protein 1 0.0241367
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0234864
TXNRD1 thioredoxin reductase 1 0.0234749
SAMD4A sterile alpha motif domain containing 4A 0.0233267
TGFBR3 transforming growth factor, beta receptor III 0.0224744
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0219043
CDC73 cell division cycle 73 0.0214753
PLK2 polo-like kinase 2 0.021016
CREB5 cAMP responsive element binding protein 5 0.0208448
MYO5C myosin VC 0.0206825
TMEM65 transmembrane protein 65 0.020332
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0200949
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0193435
EGFR epidermal growth factor receptor 0.0189621
PICALM phosphatidylinositol binding clathrin assembly protein 0.0188284
LOC112694756 uncharaterized LOC112694756 0.0186932
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0185407
ECT2 epithelial cell transforming 2 0.0184217
SGMS2 sphingomyelin synthase 2 0.0184145
NCEH1 neutral cholesterol ester hydrolase 1 0.0183658
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0182681
GLS2 glutaminase 2 (liver, mitochondrial) 0.0180553
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.0180311
ZEB1 zinc finger E-box binding homeobox 1 0.0176368
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0176057
ZNF292 zinc finger protein 292 0.0175849
TACC2 transforming, acidic coiled-coil containing protein 2 0.0175005
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0174818
ZBTB38 zinc finger and BTB domain containing 38 0.0173979
TRERF1 transcriptional regulating factor 1 0.0172024
TSC22D1 TSC22 domain family, member 1 0.0168463
USP24 ubiquitin specific peptidase 24 0.0165592
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0163319
ARID1A AT rich interactive domain 1A (SWI-like) 0.016271
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0159711
DSCAM Down syndrome cell adhesion molecule 0.0159563
CSF1 colony stimulating factor 1 (macrophage) 0.0159495
GLI3 GLI family zinc finger 3 0.0159284
PCGF5 polycomb group ring finger 5 0.0158207
NUP58 nucleoporin 58 0.0156524
ATP9B ATPase, class II, type 9B 0.015477
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 0.0153977
YAP1 Yes-associated protein 1 0.015361
ZFAND3 zinc finger, AN1-type domain 3 0.01529
MACROD2 MACRO domain containing 2 0.0152417
CAMTA1 calmodulin binding transcription activator 1 0.015177
FAT1 FAT atypical cadherin 1 0.0150847
ZNF217 zinc finger protein 217 0.01501
EIF4A2 eukaryotic translation initiation factor 4A2 0.0148261
MBNL2 muscleblind-like splicing regulator 2 0.0147496
PMM2 phosphomannomutase 2 0.0147437
MEF2A myocyte enhancer factor 2A 0.0147237
CRY1 cryptochrome circadian clock 1 0.0146993
MACF1 microtubule-actin crosslinking factor 1 0.0146766
SSBP3 single stranded DNA binding protein 3 0.0141829
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0141714
GATA6 GATA binding protein 6 0.014154
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.014151
HEG1 heart development protein with EGF-like domains 1 0.0141087
CCNL1 cyclin L1 0.0139563
CTIF CBP80/20-dependent translation initiation factor 0.0138059
KDM4C lysine (K)-specific demethylase 4C 0.0137686
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0135878
SEPTIN11 septin 11 0.0135019
PLPP3 phospholipid phosphatase 3 0.0134567
CORO1C coronin, actin binding protein, 1C 0.0134024
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0132921
DHFR dihydrofolate reductase 0.0132077
ANK2 ankyrin 2, neuronal 0.0132035
UNC5C unc-5 homolog C (C. elegans) 0.0131193
FBLN2 fibulin 2 0.0130408
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.013016
ARRDC3 arrestin domain containing 3 0.012986
NCOA2 nuclear receptor coactivator 2 0.0128489
BRWD1 bromodomain and WD repeat domain containing 1 0.0128105
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0127932
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.012743
RTN4 reticulon 4 0.0126479
NAMPT nicotinamide phosphoribosyltransferase 0.0125924
LMCD1 LIM and cysteine-rich domains 1 0.0125505

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.440302
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.236152
RPS6 ribosomal protein S6 -0.129662
TPT1 tumor protein, translationally-controlled 1 -0.124004
RPS8 ribosomal protein S8 -0.10664
RPL35A ribosomal protein L35a -0.10368
RPLP1 ribosomal protein, large, P1 -0.0860861
RPL31 ribosomal protein L31 -0.0851791
RPL34 ribosomal protein L34 -0.0762623
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0671845
RPS13 ribosomal protein S13 -0.0670172
RPL37A ribosomal protein L37a -0.0666495
RPS3 ribosomal protein S3 -0.0654982
RPL9 ribosomal protein L9 -0.0643546
RPS23 ribosomal protein S23 -0.0630194
RPL26 ribosomal protein L26 -0.0613927
RPS25 ribosomal protein S25 -0.0612332
RPLP2 ribosomal protein, large, P2 -0.0605671
RPL19 ribosomal protein L19 -0.0604135
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0599343
RPS19 ribosomal protein S19 -0.0589355
RPS27A ribosomal protein S27a -0.0575929
CENPF centromere protein F, 350/400kDa -0.0556357
MKI67 marker of proliferation Ki-67 -0.0541857
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.054105
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0538612
ACTG1 actin gamma 1 -0.0528732
NAP1L1 nucleosome assembly protein 1-like 1 -0.0519766
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0510904
RPL11 ribosomal protein L11 -0.0507537
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.050268
RPL23 ribosomal protein L23 -0.0492216
RPS24 ribosomal protein S24 -0.0479155
RPS29 ribosomal protein S29 -0.0477184
RPS12 ribosomal protein S12 -0.0468209
HSPB1 heat shock 27kDa protein 1 -0.0465235
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0456237
S100A9 S100 calcium binding protein A9 -0.0454439
KPNB1 karyopherin (importin) beta 1 -0.0452524
FOXP1 forkhead box P1 -0.043332
RPL36 ribosomal protein L36 -0.043053
SMC4 structural maintenance of chromosomes 4 -0.0418598
RPLP0 ribosomal protein, large, P0 -0.0417626
RPL12 ribosomal protein L12 -0.0401866
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0397777
FTL ferritin, light polypeptide -0.0395928
RPL13A ribosomal protein L13a -0.039104
RPL8 ribosomal protein L8 -0.0386764
CCND1 cyclin D1 -0.0385542
S100A6 S100 calcium binding protein A6 -0.03854
RPS21 ribosomal protein S21 -0.038311
EIF1 eukaryotic translation initiation factor 1 -0.0381095
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0377386
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0372598
MYL12B myosin, light chain 12B, regulatory -0.0370568
WSB1 WD repeat and SOCS box containing 1 -0.036608
RPL30 ribosomal protein L30 -0.0365138
RPL38 ribosomal protein L38 -0.0358597
BMP10 bone morphogenetic protein 10 -0.0358061
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0356487
ENO2 enolase 2 (gamma, neuronal) -0.0353544
RPL7A ribosomal protein L7a -0.0352849
TUBB4B tubulin, beta 4B class IVb -0.0351784
RPS27 ribosomal protein S27 -0.0346401
RPL37 ribosomal protein L37 -0.0344794
ENO1 enolase 1, (alpha) -0.0344593
RPL5 ribosomal protein L5 -0.0341135
RPS16 ribosomal protein S16 -0.0330699
S100A10 S100 calcium binding protein A10 -0.0328409
NAV2 neuron navigator 2 -0.0325045
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0320765
ASPH aspartate beta-hydroxylase -0.0318874
UQCRB ubiquinol-cytochrome c reductase binding protein -0.030917
RPL27A ribosomal protein L27a -0.0307295
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0302876
RPS17 ribosomal protein S17 -0.0298044
RACK1 receptor for activated C kinase 1 -0.0296534
RPL36A ribosomal protein L36a -0.02938
B2M beta-2-microglobulin -0.0293448
RPL10A ribosomal protein L10a -0.029305
RPS14 ribosomal protein S14 -0.0290354
ZMYND8 zinc finger, MYND-type containing 8 -0.0284535
HMGB1 high mobility group box 1 -0.0282011
CENPE centromere protein E, 312kDa -0.0278774
RPL32 ribosomal protein L32 -0.0276457
RPL28 ribosomal protein L28 -0.0275926
DIAPH3 diaphanous-related formin 3 -0.0275678
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0275116
VIM vimentin -0.0275041
LOC102724023 ES1 protein homolog, mitochondrial -0.0271008
RPS11 ribosomal protein S11 -0.0267418
RPS5 ribosomal protein S5 -0.0262838
RPL15 ribosomal protein L15 -0.0258742
GNAS GNAS complex locus -0.0256721
TMSB10 thymosin beta 10 -0.0256064
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0254687
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0254387
RPL35 ribosomal protein L35 -0.0254152
TPX2 TPX2, microtubule-associated -0.025191
DEK DEK proto-oncogene -0.0250404