palbociclib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description palbociclib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the palbociclib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.121415
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0837222
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.082836
FAM13A family with sequence similarity 13, member A 0.0828332
CXCL8 chemokine (C-X-C motif) ligand 8 0.0826277
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0787762
TXNIP thioredoxin interacting protein 0.078214
SMAD3 SMAD family member 3 0.0776837
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.077262
ZSWIM6 zinc finger, SWIM-type containing 6 0.0769375
FAT1 FAT atypical cadherin 1 0.0717659
FNDC3B fibronectin type III domain containing 3B 0.0702989
ANKRD28 ankyrin repeat domain 28 0.0679528
CD109 CD109 molecule 0.0663644
TRIO trio Rho guanine nucleotide exchange factor 0.064251
EMP1 epithelial membrane protein 1 0.0608004
ELL2 elongation factor, RNA polymerase II, 2 0.060369
PRRC2C proline-rich coiled-coil 2C 0.0601572
CTBP2 C-terminal binding protein 2 0.0597219
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0569677
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0564943
NDRG1 N-myc downstream regulated 1 0.054307
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0498865
LMNA lamin A/C 0.0497119
ATF3 activating transcription factor 3 0.0494396
EZR ezrin 0.0490022
SUCO SUN domain containing ossification factor 0.0489927
RICTOR RPTOR independent companion of MTOR, complex 2 0.0478922
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0478692
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0477348
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0469609
HSPA8 heat shock 70kDa protein 8 0.0465501
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0461996
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0459534
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0459017
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0456514
LIMCH1 LIM and calponin homology domains 1 0.0437811
STC2 stanniocalcin 2 0.0435505
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0429647
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0429304
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0427056
SHB Src homology 2 domain containing adaptor protein B 0.0425377
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.042069
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0420085
PDIA4 protein disulfide isomerase family A, member 4 0.0412482
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.041218
RNF145 ring finger protein 145 0.0403438
ESYT2 extended synaptotagmin-like protein 2 0.0401618
SPAG9 sperm associated antigen 9 0.0400708
DOCK5 dedicator of cytokinesis 5 0.039792
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0394367
SIRT1 sirtuin 1 0.0392863
DENND5B DENN/MADD domain containing 5B 0.0392571
WAC WW domain containing adaptor with coiled-coil 0.038291
GOLGA4 golgin A4 0.0380561
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.037865
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0377724
SFTPA2 surfactant protein A2 0.0373988
MBNL1 muscleblind-like splicing regulator 1 0.0371264
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0366238
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0363921
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0354785
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0349985
SEC23A Sec23 homolog A (S. cerevisiae) 0.0346361
PLEC plectin 0.034634
HIPK2 homeodomain interacting protein kinase 2 0.0339899
FAM107B family with sequence similarity 107, member B 0.0339841
DSTN destrin (actin depolymerizing factor) 0.0337121
DUSP6 dual specificity phosphatase 6 0.0336815
COPA coatomer protein complex, subunit alpha 0.0335934
SIK3 SIK family kinase 3 0.0333726
YBX3 Y box binding protein 3 0.0323013
LIFR leukemia inhibitory factor receptor alpha 0.0320932
RAB1A RAB1A, member RAS oncogene family 0.0317595
RB1CC1 RB1-inducible coiled-coil 1 0.0317556
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0317418
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0314887
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0314667
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0299501
ATF6 activating transcription factor 6 0.0298457
HELZ helicase with zinc finger 0.0297151
SRRM2 serine/arginine repetitive matrix 2 0.0296639
MRPS6 mitochondrial ribosomal protein S6 0.0296057
RND3 Rho family GTPase 3 0.0295579
RLF rearranged L-myc fusion 0.0294726
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0294339
SGMS2 sphingomyelin synthase 2 0.0290797
TMED9 transmembrane emp24 protein transport domain containing 9 0.0288622
SSBP2 single-stranded DNA binding protein 2 0.0283816
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0283235
MLF1 myeloid leukemia factor 1 0.0277729
UBA6 ubiquitin-like modifier activating enzyme 6 0.0275097
ARRDC3 arrestin domain containing 3 0.0274434
DSCAM Down syndrome cell adhesion molecule 0.0273683
PICALM phosphatidylinositol binding clathrin assembly protein 0.0272862
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0270859
GRB10 growth factor receptor-bound protein 10 0.0269462
ATOSA atos homolog A 0.0269122
CDC73 cell division cycle 73 0.0269016
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 0.0266559

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.182763
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.133226
HMGA2 high mobility group AT-hook 2 -0.123684
VCL vinculin -0.1124
FN1 fibronectin 1 -0.109207
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.100457
GLIS3 GLIS family zinc finger 3 -0.05859
CENPF centromere protein F, 350/400kDa -0.0565434
AEBP2 AE binding protein 2 -0.0525668
IFI27 interferon, alpha-inducible protein 27 -0.0478093
MKI67 marker of proliferation Ki-67 -0.0447441
SYT1 synaptotagmin I -0.043488
SOX4 SRY (sex determining region Y)-box 4 -0.0412266
ASPH aspartate beta-hydroxylase -0.0409723
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0367529
ITGA1 integrin, alpha 1 -0.0359488
TAS2R14 taste receptor, type 2, member 14 -0.0357027
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0354218
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.034314
OSMR oncostatin M receptor -0.0339013
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0331985
EXT1 exostosin glycosyltransferase 1 -0.032947
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0322839
MBD5 methyl-CpG binding domain protein 5 -0.0322767
DNAH5 dynein, axonemal, heavy chain 5 -0.0313746
VIM vimentin -0.0312398
EFNA5 ephrin-A5 -0.0308333
FAM20C family with sequence similarity 20, member C -0.0306314
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0303101
RAD51B RAD51 paralog B -0.0303069
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0300854
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0298527
PTMA prothymosin, alpha -0.0297072
NTN4 netrin 4 -0.0288544
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0286864
INTS6 integrator complex subunit 6 -0.0283647
ZBTB20 zinc finger and BTB domain containing 20 -0.0283161
TMSB10 thymosin beta 10 -0.02831
SOX5 SRY (sex determining region Y)-box 5 -0.0279531
DIAPH3 diaphanous-related formin 3 -0.0267597
TNS3 tensin 3 -0.0266912
NCOA7 nuclear receptor coactivator 7 -0.0259821
FTL ferritin, light polypeptide -0.0257693
NRP1 neuropilin 1 -0.0256693
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0256092
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.025236
ETV6 ets variant 6 -0.0248756
APOLD1 apolipoprotein L domain containing 1 -0.0238866
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0235108
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0235051
PRH1 proline-rich protein HaeIII subfamily 1 -0.0230259
DPYD dihydropyrimidine dehydrogenase -0.0228538
TMEM156 transmembrane protein 156 -0.0227626
WSB1 WD repeat and SOCS box containing 1 -0.0226629
DST dystonin -0.0224596
IFI16 interferon, gamma-inducible protein 16 -0.0224411
LRMDA leucine rich melanocyte differentiation associated -0.0218055
UBXN4 UBX domain protein 4 -0.0213979
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0213176
TSC22D1 TSC22 domain family, member 1 -0.0212247
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0210117
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0208058
FMN1 formin 1 -0.0202504
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0201494
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0200316
GNAS GNAS complex locus -0.0197237
RNF220 ring finger protein 220 -0.0196044
S100A6 S100 calcium binding protein A6 -0.0192424
SFRP1 secreted frizzled-related protein 1 -0.019035
LRRC23 leucine rich repeat containing 23 -0.0188917
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0188167
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0186171
SMC4 structural maintenance of chromosomes 4 -0.018531
SQSTM1 sequestosome 1 -0.01847
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0183563
HMGB3 high mobility group box 3 -0.0183188
NRIP1 nuclear receptor interacting protein 1 -0.018305
BPTF bromodomain PHD finger transcription factor -0.018268
IGFBP5 insulin-like growth factor binding protein 5 -0.0182134
IGFBP3 insulin-like growth factor binding protein 3 -0.0182015
SCLT1 sodium channel and clathrin linker 1 -0.018163
PTPRD protein tyrosine phosphatase, receptor type, D -0.0181299
TENM4 teneurin transmembrane protein 4 -0.0178201
CCDC91 coiled-coil domain containing 91 -0.0176436
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0176307
ANLN anillin, actin binding protein -0.0175741
KLHL5 kelch-like family member 5 -0.0175428
ACTG1 actin gamma 1 -0.0174226
RPS24 ribosomal protein S24 -0.0168695
RIGI RNA sensor RIG-I -0.016771
ADD3 adducin 3 (gamma) -0.0164461
ZMYND8 zinc finger, MYND-type containing 8 -0.0163229
MAML2 mastermind-like 2 (Drosophila) -0.0162635
HMGB1 high mobility group box 1 -0.0162428
SP100 SP100 nuclear antigen -0.016071
PALLD palladin, cytoskeletal associated protein -0.016048
TBC1D22A TBC1 domain family, member 22A -0.0160124
POTEF POTE ankyrin domain family, member F -0.0159424
RAB31 RAB31, member RAS oncogene family -0.015821
PDLIM5 PDZ and LIM domain 5 -0.0158069