palmoplantar keratosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A keratosis characterized by abnormal thickening of the palms and the soles. (Human Disease Ontology, DOID_3390)
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Genes

129 genes co-occuring with the disease palmoplantar keratosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
KRT9 keratin 9, type I 2.42324
AAGAB alpha- and gamma-adaptin binding protein 2.31793
KRT1 keratin 1, type II 2.1382
DSP desmoplakin 2.0859
KRT16 keratin 16, type I 2.07441
CTSC cathepsin C 2.07396
SLURP1 secreted LY6/PLAUR domain containing 1 2.0527
JUP junction plakoglobin 2.04776
GJB2 gap junction protein, beta 2, 26kDa 2.0329
KRT6A keratin 6A, type II 1.96474
DSG1 desmoglein 1 1.9094
KRT6B keratin 6B, type II 1.81465
LOR loricrin 1.81465
KRT10 keratin 10, type I 1.59698
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 1.526
GJB3 gap junction protein, beta 3, 31kDa 1.47638
LYPD2 LY6/PLAUR domain containing 2 1.44167
PKP1 plakophilin 1 1.39826
GJB6 gap junction protein, beta 6, 30kDa 1.38909
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 1.3869
KRT17 keratin 17, type I 1.33021
GJB4 gap junction protein, beta 4, 30.3kDa 1.29615
KANK2 KN motif and ankyrin repeat domains 2 1.23733
PRPF18 pre-mRNA processing factor 18 1.20137
DNAH17 dynein, axonemal, heavy chain 17 1.16435
HID1 HID1 domain containing 1.15538
KRT81 keratin 81, type II 1.14602
PKP2 plakophilin 2 1.09461
PCSK5 proprotein convertase subtilisin/kexin type 5 1.00161
KRT86 keratin 86, type II 0.998236
TAT tyrosine aminotransferase 0.986849
DSC2 desmocollin 2 0.985164
KRT24 keratin 24, type I 0.981373
KRT2 keratin 2, type II 0.980952
USB1 U6 snRNA biogenesis 1 0.95745
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 0.951604
GJA1 gap junction protein, alpha 1, 43kDa 0.949519
KRTAP11-1 keratin associated protein 11-1 0.931656
LYNX1 Ly6/neurotoxin 1 0.915963
DSC1 desmocollin 1 0.888848
RSPO4 R-spondin 4 0.882701
TRPV3 transient receptor potential cation channel, subfamily V, member 3 0.872053
SEC14L1 SEC14-like 1 (S. cerevisiae) 0.865502
NIPAL4 NIPA-like domain containing 4 0.856905
COL14A1 collagen, type XIV, alpha 1 0.841753
SOX14 SRY (sex determining region Y)-box 14 0.833558
DSG3 desmoglein 3 0.811001
CDSN corneodesmosin 0.808129
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 0.807308
ERBB2IP erbb2 interacting protein 0.795002
MBTPS2 membrane-bound transcription factor peptidase, site 2 0.776159
EVPL envoplakin 0.760231
DSG2 desmoglein 2 0.757786
RSPO1 R-spondin 1 0.755749
LIPH lipase, member H 0.755342
LPAR6 lysophosphatidic acid receptor 6 0.732596
FLG filaggrin 0.731381
KRT14 keratin 14, type I 0.72329
HELZ helicase with zinc finger 0.711183
GRHL2 grainyhead-like 2 (Drosophila) 0.708364
GJC3 gap junction protein, gamma 3, 30.2kDa 0.687091
CYGB cytoglobin 0.673917
SOSTDC1 sclerostin domain containing 1 0.65763
DSC3 desmocollin 3 0.650508
PLAUR plasminogen activator, urokinase receptor 0.636315
WNT10A wingless-type MMTV integration site family, member 10A 0.631205
IVL involucrin 0.627672
NPY5R neuropeptide Y receptor Y5 0.622575
DSG4 desmoglein 4 0.604981
AQP5 aquaporin 5 0.584719
DPYS dihydropyrimidinase 0.556344
RARG retinoic acid receptor, gamma 0.494266
NPY1R neuropeptide Y receptor Y1 0.472225
GALR2 galanin receptor 2 0.462394
CCL3L1 chemokine (C-C motif) ligand 3-like 1 0.454847
AMER1 APC membrane recruitment protein 1 0.453339
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 0.449947
UCN urocortin 0.442042
FLNA filamin A, alpha 0.442042
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 0.440914
DCSTAMP dendrocyte expressed seven transmembrane protein 0.440162
TGM1 transglutaminase 1 0.430768
POMP proteasome maturation protein 0.42364
AANAT aralkylamine N-acetyltransferase 0.418394
LGMN legumain 0.403438
DES desmin 0.39598
ADAM17 ADAM metallopeptidase domain 17 0.378143
WNT7A wingless-type MMTV integration site family, member 7A 0.369997
KRT5 keratin 5, type II 0.368518
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.362239
CTSG cathepsin G 0.337975
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.333949
GRHL1 grainyhead-like 1 (Drosophila) 0.294772
SEPT9 septin 9 0.272241
CST4 cystatin S 0.269398
GJA4 gap junction protein, alpha 4, 37kDa 0.264785
SPINK5 serine peptidase inhibitor, Kazal type 5 0.257005
DSPP dentin sialophosphoprotein 0.248905
PTEN phosphatase and tensin homolog 0.243295
SRSF2 serine/arginine-rich splicing factor 2 0.235964
KLK7 kallikrein-related peptidase 7 0.231102
UROS uroporphyrinogen III synthase 0.229716
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.216672
RECQL4 RecQ protein-like 4 0.203933
CTSS cathepsin S 0.189859
TK1 thymidine kinase 1, soluble 0.185612
RYR2 ryanodine receptor 2 (cardiac) 0.181798
SRY sex determining region Y 0.173057
CPN1 carboxypeptidase N, polypeptide 1 0.173057
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.171036
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.170789
TCHH trichohyalin 0.159838
SLPI secretory leukocyte peptidase inhibitor 0.144245
CELA1 chymotrypsin-like elastase family, member 1 0.144184
CELA3B chymotrypsin-like elastase family, member 3B 0.144111
CTSL cathepsin L 0.143099
RTEL1 regulator of telomere elongation helicase 1 0.142753
MICA MHC class I polypeptide-related sequence A 0.142652
BIRC5 baculoviral IAP repeat containing 5 0.14242
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.14228
CXCL8 chemokine (C-X-C motif) ligand 8 0.141586
PTER phosphotriesterase related 0.141307
COL1A1 collagen, type I, alpha 1 0.141156
COL1A2 collagen, type I, alpha 2 0.139784
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.139513
LCK LCK proto-oncogene, Src family tyrosine kinase 0.13887
CTSD cathepsin D 0.13815
CCL3 chemokine (C-C motif) ligand 3 0.137311
TYR tyrosinase 0.136729