pancreas Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A large lobulated gland of vertebrates that secretes digestive enzymes and the hormones insulin and glucagon. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000988)
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Genes

269 genes co-occuring with the biological term pancreas in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACE2 angiotensin I converting enzyme 2
AGER advanced glycosylation end product-specific receptor
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMACR alpha-methylacyl-CoA racemase
ARHGAP1 Rho GTPase activating protein 1
ARSG arylsulfatase G
ARX aristaless related homeobox
ASCL1 achaete-scute family bHLH transcription factor 1
ATXN8OS ATXN8 opposite strand (non-protein coding)
AURKA aurora kinase A
AVPR1B arginine vasopressin receptor 1B
BACE1 beta-site APP-cleaving enzyme 1
BCL10 B-cell CLL/lymphoma 10
BHLHE41 basic helix-loop-helix family, member e41
BIRC5 baculoviral IAP repeat containing 5
BIRC7 baculoviral IAP repeat containing 7
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRS3 bombesin-like receptor 3
CA2 carbonic anhydrase II
CARTPT CART prepropeptide
CCK cholecystokinin
CCKBR cholecystokinin B receptor
CCL20 chemokine (C-C motif) ligand 20
CD209 CD209 molecule
CD24 CD24 molecule
CD99 CD99 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEL carboxyl ester lipase
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHEK2 checkpoint kinase 2
CHMP1A charged multivesicular body protein 1A
CIZ1 CDKN1A interacting zinc finger protein 1
CLDN18 claudin 18
CLDN4 claudin 4
CLDN5 claudin 5
CLDN7 claudin 7
CLPTM1L CLPTM1-like
COL10A1 collagen, type X, alpha 1
COL18A1 collagen, type XVIII, alpha 1
CORT cortistatin
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTRC chymotrypsin C (caldecrin)
CXCL10 chemokine (C-X-C motif) ligand 10
CYBB cytochrome b-245, beta polypeptide
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DGCR2 DiGeorge syndrome critical region gene 2
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DUSP19 dual specificity phosphatase 19
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ENG endoglin
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F11 coagulation factor XI
FBXO47 F-box protein 47
FFAR4 free fatty acid receptor 4
FGFR1 fibroblast growth factor receptor 1
FMR1 fragile X mental retardation 1
FOXF1 forkhead box F1
FOXO1 forkhead box O1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GH1 growth hormone 1
GHRL ghrelin/obestatin prepropeptide
GJD2 gap junction protein, delta 2, 36kDa
GLI1 GLI family zinc finger 1
GLP1R glucagon-like peptide 1 receptor
GLUL glutamate-ammonia ligase
GNAS GNAS complex locus
GPC3 glypican 3
GPHA2 glycoprotein hormone alpha 2
GSTO2 glutathione S-transferase omega 2
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HES1 hes family bHLH transcription factor 1
HFE2 hemochromatosis type 2 (juvenile)
HHEX hematopoietically expressed homeobox
HHIP hedgehog interacting protein
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-G major histocompatibility complex, class I, G
HMBOX1 homeobox containing 1
HNF1A HNF1 homeobox A
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HP haptoglobin
HRAS Harvey rat sarcoma viral oncogene homolog
IAPP islet amyloid polypeptide
ICAM1 intercellular adhesion molecule 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IHH indian hedgehog
IL10 interleukin 10
IL18 interleukin 18
IL1B interleukin 1, beta
IL2 interleukin 2
IL22RA1 interleukin 22 receptor, alpha 1
IL33 interleukin 33
INS insulin
INSM1 insulinoma-associated 1
INSM2 insulinoma-associated 2
ISL1 ISL LIM homeobox 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNK16 potassium channel, two pore domain subfamily K, member 16
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KDM1A lysine (K)-specific demethylase 1A
KIRREL2 kin of IRRE like 2 (Drosophila)
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KLHL1 kelch-like family member 1
KLK5 kallikrein-related peptidase 5
KLK7 kallikrein-related peptidase 7
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT18 keratin 18, type I
KRT20 keratin 20, type I
LCN2 lipocalin 2
LEFTY1 left-right determination factor 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LHCGR luteinizing hormone/choriogonadotropin receptor
LIPH lipase, member H
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LTF lactotransferrin
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MARVELD2 MARVEL domain containing 2
MEN1 multiple endocrine neoplasia I
MIR196A1 microRNA 196a-1
MIR196A2 microRNA 196a-2
MIR421 microRNA 421
MLH1 mutL homolog 1
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MRPL37 mitochondrial ribosomal protein L37
MSH2 mutS homolog 2
MUC1 mucin 1, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC4 mucin 4, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC6 mucin 6, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO15A myosin XVA
NANOG Nanog homeobox
NDRG1 N-myc downstream regulated 1
NEUROG3 neurogenin 3
NGF nerve growth factor (beta polypeptide)
NOBOX NOBOX oogenesis homeobox
NPPA natriuretic peptide A
NPTX2 neuronal pentraxin II
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR5A1 nuclear receptor subfamily 5, group A, member 1
NR5A2 nuclear receptor subfamily 5, group A, member 2
NRP1 neuropilin 1
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
ONECUT1 one cut homeobox 1
PABPC1L poly(A) binding protein, cytoplasmic 1-like
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PALLD palladin, cytoskeletal associated protein
PAX8 paired box 8
PBX1 pre-B-cell leukemia homeobox 1
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDIA2 protein disulfide isomerase family A, member 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PDX1 pancreatic and duodenal homeobox 1
PEBP1 phosphatidylethanolamine binding protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PGR progesterone receptor
PIAS4 protein inhibitor of activated STAT, 4
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKD3 polycystic kidney disease 3 (autosomal dominant)
PLAU plasminogen activator, urokinase
PNPLA2 patatin-like phospholipase domain containing 2
PON1 paraoxonase 1
POSTN periostin, osteoblast specific factor
PRF1 perforin 1 (pore forming protein)
PROK1 prokineticin 1
PRSS1 protease, serine, 1 (trypsin 1)
PRSS22 protease, serine, 22
PRSS27 protease, serine 27
PTAFR platelet-activating factor receptor
PTCH1 patched 1
PTGDR2 prostaglandin D2 receptor 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRN protein tyrosine phosphatase, receptor type, N
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
REG3G regenerating islet-derived 3 gamma
REG4 regenerating islet-derived family, member 4
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RIOK3 RIO kinase 3
RREB1 ras responsive element binding protein 1
RRM2 ribonucleotide reductase M2
RXRA retinoid X receptor, alpha
S100P S100 calcium binding protein P
SAA1 serum amyloid A1
SBDS Shwachman-Bodian-Diamond syndrome
SCTR secretin receptor
SDC1 syndecan 1
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SHH sonic hedgehog
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SMAD4 SMAD family member 4
SMO smoothened, frizzled class receptor
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPP1 secreted phosphoprotein 1
STAR steroidogenic acute regulatory protein
STARD13 StAR-related lipid transfer (START) domain containing 13
STK11 serine/threonine kinase 11
SYNE1 spectrin repeat containing, nuclear envelope 1
TAS1R3 taste receptor, type 1, member 3
TBX4 T-box 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF1 trefoil factor 1
TFF2 trefoil factor 2
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TMEM192 transmembrane protein 192
TMEM97 transmembrane protein 97
TMSB4X thymosin beta 4, X-linked
TNC tenascin C
TNF tumor necrosis factor
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS4 tensin 4
TP53 tumor protein p53
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TYMP thymidine phosphorylase
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UTRN utrophin
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WFDC2 WAP four-disulfide core domain 2
WNT16 wingless-type MMTV integration site family, member 16
YAP1 Yes-associated protein 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta