pancreatic islet Gene Set

Dataset TISSUES Curated Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description Irregular microscopic structures scattered throughout the pancreas and comprising its endocrine part (the endocrine pancreas). In humans, they are composed of at least four types of cells: the alpha cells, which secrete glucagon; the beta cells, which are the most abundant and secrete insulin; the delta cells, which secrete somatostatin; and the PP cells, which secrete pancreatic polypeptide. Degeneration of the beta cells, whose secretion (insulin) is important in carbohydrate metabolism, is the major cause of type I diabetes mellitus. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000991)
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Genes

23 proteins highly expressed in the tissue pancreatic islet from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
AGTRAP angiotensin II receptor-associated protein
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
ECI2 enoyl-CoA delta isomerase 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GLP1R glucagon-like peptide 1 receptor
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ICA1 islet cell autoantigen 1, 69kDa
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
ISL1 ISL LIM homeobox 1
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
NEK7 NIMA-related kinase 7
NKX6-1 NK6 homeobox 1
PDX1 pancreatic and duodenal homeobox 1
PFKP phosphofructokinase, platelet
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PTPRN protein tyrosine phosphatase, receptor type, N
SCGN secretagogin, EF-hand calcium binding protein
SOX13 SRY (sex determining region Y)-box 13
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
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