paranodal junction Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath. (Gene Ontology, GO_0033010)
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Genes

43 proteins co-occuring with the paranodal junction cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CNTNAP1 contactin associated protein 1 2.80588
NFASC neurofascin 2.02132
GAL3ST1 galactose-3-O-sulfotransferase 1 1.82389
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 1.26075
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 1.2518
GLDN gliomedin 1.06701
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.965993
SPTBN4 spectrin, beta, non-erythrocytic 4 0.905531
CKAP4 cytoskeleton-associated protein 4 0.875028
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 0.764527
GJC2 gap junction protein, gamma 2, 47kDa 0.762707
ADAM22 ADAM metallopeptidase domain 22 0.656464
SH3GL1 SH3-domain GRB2-like 1 0.62393
NRCAM neuronal cell adhesion molecule 0.615013
CNTN2 contactin 2 (axonal) 0.612471
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 0.611201
PTPRB protein tyrosine phosphatase, receptor type, B 0.559285
ADD2 adducin 2 (beta) 0.523067
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 0.49742
SEPT2 septin 2 0.480855
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.470406
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 0.454816
SPTBN1 spectrin, beta, non-erythrocytic 1 0.424745
MAG myelin associated glycoprotein 0.42082
CEP290 centrosomal protein 290kDa 0.414555
NTN1 netrin 1 0.403637
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.386979
ANK2 ankyrin 2, neuronal 0.35899
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.332472
RTN4R reticulon 4 receptor 0.319702
RPE65 retinal pigment epithelium-specific protein 65kDa 0.308494
RDX radixin 0.304027
PLP1 proteolipid protein 1 0.300311
PMP22 peripheral myelin protein 22 0.274468
RTN4 reticulon 4 0.273367
MSN moesin 0.272267
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.26385
NF2 neurofibromin 2 (merlin) 0.229176
EZR ezrin 0.21681
MOG myelin oligodendrocyte glycoprotein 0.205399
ARSA arylsulfatase A 0.199659
MBP myelin basic protein 0.174087
HMGA2 high mobility group AT-hook 2 0.166643