paraplegia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

329 genes co-occuring with the disease paraplegia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SPAST spastin 3.32679
SPG11 spastic paraplegia 11 (autosomal recessive) 2.70807
ATL1 atlastin GTPase 1 2.69797
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 2.48741
REEP1 receptor accessory protein 1 2.27637
KIF5A kinesin family member 5A 2.22926
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 2.13567
ZFYVE26 zinc finger, FYVE domain containing 26 2.09055
L1CAM L1 cell adhesion molecule 2.07715
SPG20 spastic paraplegia 20 (Troyer syndrome) 2.059
KIAA0196 KIAA0196 2.0491
ZFYVE27 zinc finger, FYVE domain containing 27 2.01796
PLP1 proteolipid protein 1 1.9727
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 1.97082
IFT122 intraflagellar transport 122 1.87745
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 1.74778
AFG3L2 AFG3-like AAA ATPase 2 1.72912
FA2H fatty acid 2-hydroxylase 1.69405
RTN2 reticulon 2 1.6525
DDHD2 DDHD domain containing 2 1.57067
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 1.55557
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit 1.54186
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.47154
REEP2 receptor accessory protein 2 1.47023
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 1.461
CCDC62 coiled-coil domain containing 62 1.44342
SLC30A6 solute carrier family 30 (zinc transporter), member 6 1.40395
PNPLA6 patatin-like phospholipase domain containing 6 1.39127
GJC2 gap junction protein, gamma 2, 47kDa 1.38341
SNX15 sorting nexin 15 1.31319
AP4B1 adaptor-related protein complex 4, beta 1 subunit 1.2765
DDHD1 DDHD domain containing 1 1.25863
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 1.19618
CCDC53 coiled-coil domain containing 53 1.14433
KIF5C kinesin family member 5C 1.1312
KIF1A kinesin family member 1A 1.11814
ERLIN2 ER lipid raft associated 2 1.10889
DPY30 dpy-30 homolog (C. elegans) 1.09545
KATNA1 katanin p60 (ATPase containing) subunit A 1 1.08621
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 1.0753
EMC8 ER membrane protein complex subunit 8 1.05009
SACS sacsin molecular chaperone 1.04125
EXOSC3 exosome component 3 1.03704
KIF1C kinesin family member 1C 1.0265
PNPLA7 patatin-like phospholipase domain containing 7 1.02566
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 1.02397
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 1.01976
AP5M1 adaptor-related protein complex 5, mu 1 subunit 1.01301
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 1.00625
NIPAL4 NIPA-like domain containing 4 0.988957
PI4K2A phosphatidylinositol 4-kinase type 2 alpha 0.985164
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.985164
MYO1H myosin IH 0.981794
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.975062
GBA2 glucosidase, beta (bile acid) 2 0.97296
MBP myelin basic protein 0.97086
SURF4 surfeit 4 0.964567
TMCO5A transmembrane and coiled-coil domains 5A 0.964567
RTN1 reticulon 1 0.93497
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 0.933313
ELOVL6 ELOVL fatty acid elongase 6 0.932898
MRPL43 mitochondrial ribosomal protein L43 0.931656
NRCAM neuronal cell adhesion molecule 0.927519
EEA1 early endosome antigen 1 0.924213
C15ORF41 chromosome 15 open reading frame 41 0.922561
DNAH8 dynein, axonemal, heavy chain 8 0.922561
ATXN3 ataxin 3 0.918436
AP4M1 adaptor-related protein complex 4, mu 1 subunit 0.917611
SNX7 sorting nexin 7 0.915963
C12ORF65 chromosome 12 open reading frame 65 0.909787
C15ORF53 chromosome 15 open reading frame 53 0.90732
GCH1 GTP cyclohydrolase 1 0.868368
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) 0.864274
WASH1 WAS protein family homolog 1 0.862637
LDB1 LIM domain binding 1 0.862228
GSE1 Gse1 coiled-coil protein 0.855268
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.853221
KIF13B kinesin family member 13B 0.851992
GPM6B glycoprotein M6B 0.847488
CLMB calcimembrin 0.846669
REEP6 receptor accessory protein 6 0.834378
HSPE1 heat shock 10kDa protein 1 0.833558
PNPLA1 patatin-like phospholipase domain containing 1 0.829869
ALDH16A1 aldehyde dehydrogenase 16 family, member A1 0.823718
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.821257
KATNB1 katanin p80 (WD repeat containing) subunit B 1 0.817155
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.81059
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 0.807718
PQBP1 polyglutamine binding protein 1 0.801564
KIF5B kinesin family member 5B 0.792131
ASRGL1 asparaginase like 1 0.790081
COL6A1 collagen, type VI, alpha 1 0.785574
MFN2 mitofusin 2 0.782298
IFT81 intraflagellar transport 81 0.781479
PLLP plasmolipin 0.777795
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 0.763086
ATL3 atlastin GTPase 3 0.735027
KIAA1033 KIAA1033 0.728547
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.722077
MAPRE3 microtubule-associated protein, RP/EB family, member 3 0.718443
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.712796
MON1A MON1 secretory trafficking family member A 0.71078
GBP3 guanylate binding protein 3 0.70233
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.692697
ZNF512B zinc finger protein 512B 0.676706
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.674713
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) 0.664769
VCP valosin containing protein 0.656441
WASH7P WAS protein family homolog 7 pseudogene 0.64577
WASH6P WAS protein family homolog 6 pseudogene 0.639463
YME1L1 YME1-like 1 ATPase 0.633169
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 0.626495
SOD2 superoxide dismutase 2, mitochondrial 0.624927
BOLA3 bolA family member 3 0.623359
BAD BCL2-associated agonist of cell death 0.6214
CNTN6 contactin 6 0.618268
CPLX4 complexin 4 0.612792
RAB11B RAB11B, member RAS oncogene family 0.606933
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1 0.59991
CALCA calcitonin-related polypeptide alpha 0.59952
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.594454
RNASEH2B ribonuclease H2, subunit B 0.583941
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.580439
BICD2 bicaudal D homolog 2 (Drosophila) 0.577327
RAB43 RAB43, member RAS oncogene family 0.574605
HSPB8 heat shock 22kDa protein 8 0.562946
DCTN1 dynactin 1 0.560616
TRAK1 trafficking protein, kinesin binding 1 0.557897
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.55518
EPS15 epidermal growth factor receptor pathway substrate 15 0.53928
UBE3B ubiquitin protein ligase E3B 0.530381
C17ORF85 chromosome 17 open reading frame 85 0.529222
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 0.52729
GPHN gephyrin 0.520731
GINS2 GINS complex subunit 2 (Psf2 homolog) 0.512648
FNDC3A fibronectin type III domain containing 3A 0.512264
TMEM126A transmembrane protein 126A 0.511112
GALNS galactosamine (N-acetyl)-6-sulfatase 0.510344
CD2 CD2 molecule 0.507657
ARL2BP ADP-ribosylation factor-like 2 binding protein 0.507273
NBAS neuroblastoma amplified sequence 0.50689
DNTT DNA nucleotidylexotransferase 0.504207
AAAS achalasia, adrenocortical insufficiency, alacrimia 0.504207
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.503824
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 0.503824
TSPAN2 tetraspanin 2 0.493122
MAP2 microtubule-associated protein 2 0.486646
GRID2 glutamate receptor, ionotropic, delta 2 0.484744
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 0.482084
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.480945
LHB luteinizing hormone beta polypeptide 0.47374
NKX1-1 NK1 homeobox 1 0.469954
DLG3 discs, large homolog 3 (Drosophila) 0.456732
PDYN prodynorphin 0.455978
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 0.452962
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) 0.452208
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 0.449947
MFN1 mitofusin 1 0.448064
CNTLN centlein, centrosomal protein 0.447311
NUMBL numb homolog (Drosophila)-like 0.446182
RTN3 reticulon 3 0.4443
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 0.442418
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 0.436778
CCS copper chaperone for superoxide dismutase 0.436402
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.436026
GLRX5 glutaredoxin 5 0.431894
HLX H2.0-like homeobox 0.431144
AIF1 allograft inflammatory factor 1 0.430017
GJC3 gap junction protein, gamma 3, 30.2kDa 0.422515
PARL presenilin associated, rhomboid-like 0.418019
ARL2 ADP-ribosylation factor-like 2 0.416521
OMD osteomodulin 0.408292
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.406051
AQP4 aquaporin 4 0.406051
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 0.402692
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.397471
CKAP4 cytoskeleton-associated protein 4 0.396725
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.395608
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.394863
TUBA1A tubulin, alpha 1a 0.392257
KTN1 kinectin 1 (kinesin receptor) 0.391141
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 0.390769
SETX senataxin 0.390025
C19ORF12 chromosome 19 open reading frame 12 0.389281
GALC galactosylceramidase 0.388166
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.388166
ALPPL2 alkaline phosphatase, placental-like 2 0.387794
ENO2 enolase 2 (gamma, neuronal) 0.387794
ALPP alkaline phosphatase, placental 0.387423
ALPL alkaline phosphatase, liver/bone/kidney 0.387051
MPLKIP M-phase specific PLK1 interacting protein 0.384079
CHD8 chromodomain helicase DNA binding protein 8 0.381481
MAP1A microtubule-associated protein 1A 0.380739
TTBK2 tau tubulin kinase 2 0.378514
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 0.37555
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.373698
LIAS lipoic acid synthetase 0.372217
DSC3 desmocollin 3 0.371847
MAL mal, T-cell differentiation protein 0.371477
IVL involucrin 0.366671
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.365932
ARSA arylsulfatase A 0.364085
MEIS2 Meis homeobox 2 0.354868
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.351555
NOL9 nucleolar protein 9 0.351555
TFG TRK-fused gene 0.351187
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.349717
ATL2 atlastin GTPase 2 0.347144
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 0.337242
BHLHE22 basic helix-loop-helix family, member e22 0.333583
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.33066
SUB1 SUB1 homolog (S. cerevisiae) 0.330295
ARRB2 arrestin, beta 2 0.3292
AMY2A amylase, alpha 2A (pancreatic) 0.328469
PTH parathyroid hormone 0.32774
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.32774
FEZF2 FEZ family zinc finger 2 0.326646
GJB1 gap junction protein, beta 1, 32kDa 0.319363
AUTS2 autism susceptibility candidate 2 0.318272
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 0.311739
ATXN2 ataxin 2 0.304864
AMIGO2 adhesion molecule with Ig-like domain 2 0.303781
BTD biotinidase 0.303059
SOD1 superoxide dismutase 1, soluble 0.293694
OGN osteoglycin 0.292257
ITCH itchy E3 ubiquitin protein ligase 0.291539
AGK acylglycerol kinase 0.290462
UNC5C unc-5 homolog C (C. elegans) 0.28831
PDZD4 PDZ domain containing 4 0.28294
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 0.275445
HSPB1 heat shock 27kDa protein 1 0.274021
TRPC7 transient receptor potential cation channel, subfamily C, member 7 0.272953
PLIN3 perilipin 3 0.272241
TBR1 T-box, brain, 1 0.27153
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 0.266913
MAG myelin associated glycoprotein 0.264077
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 0.261952
ETV3 ets variant 3 0.260184
TH tyrosine hydroxylase 0.25877
CAPN1 calpain 1, (mu/I) large subunit 0.256652
IMPACT impact RWD domain protein 0.255946
NOS1 nitric oxide synthase 1 (neuronal) 0.254183
TTC34 tetratricopeptide repeat domain 34 0.251366
BIN2 bridging integrator 2 0.250663
RAE1 ribonucleic acid export 1 0.250663
SYP synaptophysin 0.250311
PRKCG protein kinase C, gamma 0.249257
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.24715
GJB4 gap junction protein, beta 4, 30.3kDa 0.24715
MLX MLX, MAX dimerization protein 0.245046
TCHH trichohyalin 0.241895
MALL mal, T-cell differentiation protein-like 0.239799
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.239101
F12 coagulation factor XII (Hageman factor) 0.23492
AFF2 AF4/FMR2 family, member 2 0.230409
TPPP tubulin polymerization promoting protein 0.22937
CHRND cholinergic receptor, nicotinic, delta (muscle) 0.22937
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.227642
GLDC glycine dehydrogenase (decarboxylating) 0.221793
IGF2R insulin-like growth factor 2 receptor 0.22145
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.217012
CHRM1 cholinergic receptor, muscarinic 1 0.211261
PMP22 peripheral myelin protein 22 0.210589
S100B S100 calcium binding protein B 0.210589
NPS neuropeptide S 0.209583
PLIN2 perilipin 2 0.207578
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.200656
FBXO7 F-box protein 7 0.198709
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.197742
INS insulin 0.19742
PLAT plasminogen activator, tissue 0.196459
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 0.194232
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.193285
PANK1 pantothenate kinase 1 0.192657
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.192657
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.192657
UBQLN2 ubiquilin 2 0.191097
SPTBN2 spectrin, beta, non-erythrocytic 2 0.189859
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 0.189859
AATF apoptosis antagonizing transcription factor 0.188938
AURKAIP1 aurora kinase A interacting protein 1 0.188022
PLEK pleckstrin 0.18621
CRP C-reactive protein, pentraxin-related 0.18621
CD4 CD4 molecule 0.18591
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 0.185016
HSPA4 heat shock 70kDa protein 4 0.183541
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.182375
SATB2 SATB homeobox 2 0.182086
PSEN1 presenilin 1 0.178403
SPRED1 sprouty-related, EVH1 domain containing 1 0.174354
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 0.173571
TRH thyrotropin-releasing hormone 0.170299
F2 coagulation factor II (thrombin) 0.16933
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 0.168617
CKAP5 cytoskeleton associated protein 5 0.167452
FEV FEV (ETS oncogene family) 0.166995
LITAF lipopolysaccharide-induced TNF factor 0.165435
HLA-DMA major histocompatibility complex, class II, DM alpha 0.165217
C9ORF72 chromosome 9 open reading frame 72 0.164359
GARS glycyl-tRNA synthetase 0.162505
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.160761
DNM1 dynamin 1 0.160761
CD79A CD79a molecule, immunoglobulin-associated alpha 0.160203
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 0.159838
BIK BCL2-interacting killer (apoptosis-inducing) 0.159302
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.159124
MAPT microtubule-associated protein tau 0.158266
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 0.157929
RNF31 ring finger protein 31 0.157602
PTCH1 patched 1 0.145583
TTR transthyretin 0.143843
FTL ferritin, light polypeptide 0.142145
FTH1 ferritin, heavy polypeptide 1 0.142145
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.140593
IGHMBP2 immunoglobulin mu binding protein 2 0.140032
EPHB3 EPH receptor B3 0.138999
GDAP1 ganglioside induced differentiation associated protein 1 0.138663
APTX aprataxin 0.13811
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.137622
ATXN7 ataxin 7 0.136923
SORT1 sortilin 1 0.136907
MCF2 MCF.2 cell line derived transforming sequence 0.13668
IMMT inner membrane protein, mitochondrial 0.135974
CDK5 cyclin-dependent kinase 5 0.135791
PNPLA2 patatin-like phospholipase domain containing 2 0.135548
KIF1B kinesin family member 1B 0.135548
ATP7A ATPase, Cu++ transporting, alpha polypeptide 0.135375
TCF4 transcription factor 4 0.135356
MAP1B microtubule-associated protein 1B 0.134623